Publications by authors named "Yair Delgado-Namorado"
Article Synopsis
- The study investigated the impact of 12 Single Nucleotide Polymorphisms (SNPs) in the SORL1 gene on the risk of Late-Onset Alzheimer's Disease (LOAD) specifically in the Mexican population, alongside examining interactions with the well-known APOE genotype.
- Data was collected from 156 patients diagnosed with LOAD and 221 control subjects through thorough medical examinations and genetic testing, focusing on SNP frequencies and ancestry.
- Results suggested that the A/A genotype of rs1784933 is linked to increased LOAD risk, especially when combined with other genetic variants and the APOE ε4 allele, highlighting potential genetic markers for LOAD diagnosis within the Mexican population.
Significance: Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is the case of Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors. Recent Advances: In recent decades, it has been widely described that MetS increases the risk of cognitive impairment and dementia.
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