Publications by authors named "Yahya S Al-Matary"
Background: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous disease characterized by progressive cholestasis in early childhood. Surgical therapy aims at preventing bile absorption either by external or internal biliary diversion (BD). Several different genetic subtypes encode for defects in bile transport proteins, and new subtypes are being discovered ongoingly.
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- Acute myeloid leukaemia (AML) is a serious type of blood cancer that doesn’t have a good chance of recovery.
- Research showed that cells from the bone marrow of people with AML help leukaemia cells survive chemotherapy by using a special process called Notch signalling.
- Using a drug called dexamethasone blocked this Notch signalling, helping to reduce the number of leukaemia cells and improve survival in tests with mice.
Differentiation of hematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factor function can be the basis of (pre)malignancies such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Growth factor independence 1b (Gfi1b) is a repressing transcription factor regulating quiescence of hematopoietic stem cells and differentiation of erythrocytes and platelets.
View Article and Find Full Text PDFThe differentiation of haematopoietic cells is regulated by a plethora of so-called transcription factors (TFs). Mutations in genes encoding TFs or graded reduction in their expression levels can induce the development of various malignant diseases such as acute myeloid leukaemia (AML). Growth Factor Independence 1 (GFI1) is a transcriptional repressor with key roles in haematopoiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and lymphoid differentiation.
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- Malignant cells grow not just from their own factors, but also from the environment around them, especially cells like monocytes and macrophages.
- In acute myeloid leukemia, certain macrophages help the cancer grow instead of fighting it, and their presence in the body is linked to how long mice survive in experiments.
- A specific protein called Growth factor independence 1 is important because it affects how these macrophages change; without it, they are less likely to support the cancer.