Electron-Triggered Imine Coupling: Synthesis and Characterization of Three Redox States (0,-1,-2) of a Ni(N S ) Complex.

Metal imine-thiolate complexes, M(NS) are known to undergo imine C-C bond formation to give M(N S ) complexes (M=Co, Ni) containing a redox-active ligand. Although these transfor-mations are not typically quantitative, we demonstrate here that the one-electron reduction of a related Ni bis(imine-thiolate) complex affords the corresponding paramagnetic [Ni(N S )] anion (2⋅ ) exclusively; subsequent oxidation with [Cp Fe]BF then affords a high yield of neutral 2 (Cp=η -cyclopentadienyl). Moreover, electrochemical studies indicate that a second one-electron reduction affords the diamagnetic dianion.

Nickel(II)-SNS Thiolate Complexes: Reactivity and Solution Dynamics.

Nickel coordination chemistry with a biomimetic thiolate-imine-thioether SNS ligand is accompanied by diverse reactivity and multidentate ligand dynamics. Reaction of Ni(acac) with 2 equiv of 2-(methylthio)-phenyl-benzothiazolidine (MPB) affords the bis(arylimino-phenylene-thiolate) complex Ni(κ-SNS) (; acac = acetylacetonate). Thermolysis of in refluxing toluene is accompanied by imine C-C bond formation, yielding [Ni(NS)] () with a redox-active ligand.

Cytotoxicity of Manganese (III) Complex in Human Breast Adenocarcinoma Cell Line Is Mediated by the Generation of Reactive Oxygen Species Followed by Mitochondrial Damage.

Manganese (Mn) complexes are widely studied because of their important catalytic properties in synthetic and biochemical reactions. A Mn (III) complex of an amidoamine ligand was synthesized using a tetradentate amidoamine ligand. In this study, the Mn (III) complex was evaluated for its biological activity by measuring its cytotoxicity in human breast adenocarcinoma cell line (MCF-7).