Publications by authors named "Yahya Hassan Hobani"
Article Synopsis
- The study aimed to assess the prevalence of alpha thalassemia and identify gene mutations in people undergoing premarital screening in Jazan, Saudi Arabia.
- Approximately 4.43% of the 3,970 blood samples analyzed showed signs of alpha thalassemia, with genetic tests confirming mutations in 95% of suspected cases.
- The findings highlight a significant presence of alpha thalassemia in the region, underscoring the importance of genetic screening in premarital assessments.
The role of niacin's metabolite, nicotinamide adenine dinucleotide (NAD), in DNA repair via base-excision repair pathway is well documented. We evaluated if niacin deficiency results in genetic instability in normal human fetal lung fibroblasts (MRC-5), and further, does it leads to enhanced accumulation of cigarette smoke-induced genetic damage? MRC-5 cells were grown discretely in niacin-proficient/deficient media, and exposed to nicotine-derived nitrosamine ketone (NNK, a cigarette smoke carcinogen). Niacin deficiency abated the NAD polymerization, augmented the spontaneous induction of micronuclei (MN) and chromosomal aberrations (CA) and raised the expression of 10 genes and suppressed 12 genes involved in different biological functions.
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