Publications by authors named "Yahu Miao"
Background: Mitochondrial dysfunction plays a crucial role in Type 2 Diabetes Mellitus (T2DM) and its complications. However, the genetic pathophysiology remains under investigation. Through multi-omics Mendelian Randomization (MR) and colocalization analyses, we identified mitochondrial-related genes causally linked with T2DM and its complications.
View Article and Find Full Text PDFPurpose: The association between type 2 diabetes mellitus (T2DM), lifestyle factors, and the risk of osteoporosis (OP) is well-established. However, the impact of a healthy lifestyle on diabetes-related osteoporosis needs further investigation. Our objective was to explore if a combination of healthy lifestyle factors could mitigate the risk of OP in individuals with type 2 diabetes.
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- Exhausted CD8 T cells and tumor-associated macrophages are important for understanding how cancer affects patients and how well immunotherapy works.
- In thyroid cancer, researchers found that the more exhausted the CD8 T cells were, the worse the patient's prognosis was, and they divided patients into two groups based on this exhaustion.
- By analyzing specific genes, they created a risk score (ERGS) that can help predict how patients will do and how well they might respond to immunotherapy, and they identified certain immune cells that might make treatment less effective.
Background: Body mass index (BMI) is an important risk factor for hypertension in diabetic patients. However, the underlying mechanisms remain poorly understood. Although liver-derived biological intermediates may play irreplaceable roles in the pathophysiology of diabetes, few studies have explored them in the association between BMI and hypertension in diabetes.
View Article and Find Full Text PDFCircular RNAs (circRNAs) play an important role in regulating the development of human cancers through diverse biological functions. However, the exact molecular mechanisms underlying the role of circRNAs in papillary thyroid cancer (PTC) remain largely unknown. Here, we found that hsa_circ_0011385, designated as circular eukaryotic translation initiation factor 3 subunit I (circEIF3I), preferentially localized in the cytoplasm of PTC cells and was more stable than its linear counterpart, EIF3I.
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- - The study investigated how midday napping, sleep quality, and insulin resistance relate to hypertension in type 2 diabetes patients, revealing that poor sleep and obesity significantly increase hypertension risk.
- - Findings showed a 50% prevalence of hypertension among participants, with factors like age, sleep quality, hyperlipidemia, family history, and obesity contributing to higher risks, while short midday naps were linked to lower hypertension odds.
- - The conclusion emphasizes that poor sleep and obesity are crucial risk factors for hypertension, but taking short naps (1-30 minutes) can help reduce the risk in those with type 2 diabetes.
Background: Autoimmune thyroid disease (AITD) is induced by various factors, including inheritability, which regulates gene expression. Multiple loci correlated with AITD have been discovered utilizing genome-wide association studies (GWASs). Nevertheless, demonstrating the biological relevance and function of these genetic loci is difficult.
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