Publications by authors named "Yahia Moualla"
Article Synopsis
- Nucleophosmin (NPM1) gene mutations are found in 30%-35% of acute myeloid leukemia (AML) patients, with higher prevalence (50%-60%) among those with a normal karyotype.
- In a study involving 100 newly diagnosed Syrian AML patients, 22% exhibited NPM1 mutations, primarily of type A, and their presence was linked to worse outcomes, such as higher mortality rates and increased bone marrow blast percentages.
- These findings highlight the importance of assessing NPM1 mutations for better prognosis and tailored treatment strategies in AML patients with normal karyotypes.
The FMS-like tyrosine kinase-3 internal tandem duplication (-ITD) is one of the most prevalent mutations, affecting between 20 and 30 percent of cases in patients with acute myeloid leukemia (AML). The Patients with a -ITD mutation have a poor prognosis. In the present study, we investigated the (ITD-TKD) mutations in 100 newly adult Syrian patients with AML-Normal karyotype (NK).
View Article and Find Full Text PDFObjective: Among all types of hematological neoplasms, acute myeloid leukemia (AML) has the highest death rate. Recently, cytogenetic and molecular genetics are crucial in the management, as a consequence of their effect on AML pathogenesis, classification, risk-stratification, prognosis and treatment.
Methods: 100 Syrian adults with Normal Karyotype (NK) newly diagnosed AML patients were included in this study, all cases confirmed histologically and immunohistochemically.