Publications by authors named "Yahia Achour"

Background: Early detection of cancerous tumors is a critical factor in improving treatment outcomes. To address this need, this study explores a simple, effective, and cost-efficient method for early cancer detection by measuring the bioimpedance of living tissues. Bioimpedance-based methods hold significant promise for the early detection of cancerous tumors.

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Cancer remains a global health challenge, necessitating effective treatments with fewer side effects. Traditional methods such as chemotherapy and surgery often have complications. Pulsed electric fields and electroporation have emerged as promising approaches to mitigate these challenges.

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To enhance our understanding of electroporation and optimize the pulses used within the frequency range of 1 kHz to 100 MHz, with the aim of minimizing side effects such as muscle contraction, we introduce a novel electrical model, structured as a 2D representation employing exclusively lumped elements. This model adeptly encapsulates the intricate dynamics of living cells' impedance variation. A distinguishing attribute of the proposed model lies in its capacity to decipher the distribution of transmembrane potential across various orientations within living cells.

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The purpose of this study was to verify whether the nanosecond pulsed electric field, not eliciting thermal effects, permanently changes the molecular processes and gene expression of Leydig TM3 cells. The cells were exposed to a moderate electric field (80 quasi-rectangular shape pulses, 60 ns pulse width, and an electric field of 14 kV/cm). The putative disturbances were recorded over 24 h.

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