Publications by authors named "Yaguchi H"

An 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma.

View Article and Find Full Text PDF

Transition-metal oxyhydrides are an emerging class of functional materials; however, the known compounds have mostly been limited to perovskite-type sturctures. Here, we successfully synthesized LiNbHO, the first example of a rock-salt-type transition-metal oxyhydride, using mechanochemical methods. Galvanostatic charge/discharge tests revealed that LiNbHO functions as an electrode for lithium secondary batteries.

View Article and Find Full Text PDF

Clinical diagnosis of progressive supranuclear palsy (PSP) is difficult due to various phenotypes. Neuropathologically, PSP is defined by neuronal loss in the basal ganglia and brainstem with widespread occurrence of neurofibrillary tangles (NFTs) and accumulation of phosphorylated tau protein in neurons and glial cells in the brain. We previously identified the point mutation p.

View Article and Find Full Text PDF

To understand the mechanisms underlying social evolution and caste development in social insects, caste-specific organs and genes should be investigated. In the rhinotermitid termite, Reticulitermes speratus, the lipocalin gene RS008881, which encodes a protein transporter, is expressed in the ovarian accessory glands of primary queens. To obtain additional data on its expression and product localization, we conducted real-time quantitative polymerase chain reaction and protein assays using a peptide antibody.

View Article and Find Full Text PDF

Over the past decade, the photovoltaic (PV) performance of perovskite solar cells (PSCs) has been considerably improved with the development of perovskite photoabsorbers. Among these, formamidinium-lead-iodide (FAPbI) is a promising photoabsorber owing to its narrow bandgap and is mainly used in n-i-p-structured PSCs. The property modulation of FAPbI photoabsorbers while retaining their narrow bandgap is imperative for further development of PSCs.

View Article and Find Full Text PDF

Background: Thrombectomy is a standard treatment for acute large vessel occlusion (LVO); however, its effectiveness in treating LVO related to intracranial atherosclerosis disease (ICAD) remains uncertain. This study aimed to compare thrombectomy outcomes in ICAD-related and embolic LVO, focusing on patients with similar symptom severities upon hospital admission.

Methods: This retrospective study was conducted at Jikei University Hospital and Jikei University Kashiwa Hospital between October 2017 and March 2023.

View Article and Find Full Text PDF

Tauopathy is known to be a major pathognomonic finding in important neurodegenerative diseases such as progressive supranuclear palsy (PSP) and corticobasal degeneration. However, the mechanism by which tauopathy is triggered remains to be elucidated. We previously identified the point mutation c.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the use of pose estimation algorithms to distinguish between Parkinson's disease (PD) and spinocerebellar degeneration (SCD) through video analysis of patient gait.
  • Researchers recorded 82 PD patients and 61 SCD patients during a mobility test and utilized a deep neural network model trained on gait data to make predictions on the neurological disorder.
  • Results indicated high accuracy (0.86), sensitivity (0.94), and specificity (0.75) for differentiating PD from SCD, suggesting this method could be valuable in clinical settings and telemedicine for improved patient assessment.
View Article and Find Full Text PDF
Article Synopsis
  • POEMS syndrome is a serious condition often linked to a poor prognosis, and elevated serum vascular endothelial growth factor (sVEGF) is a key diagnostic marker for it.
  • The connection between sVEGF levels and polyneuropathy in POEMS syndrome is debated.
  • A case study highlights that a patient initially showed no sVEGF elevation despite polyneuropathy but later tested positive, suggesting the need for ongoing sVEGF testing in atypical cases.
View Article and Find Full Text PDF
Article Synopsis
  • Paraneoplastic neurological syndromes (PNS) are disorders linked to tumors, where anti-neural antibodies may be present, and cerebellar ataxia is a common example in breast cancer patients.
  • Improvement in symptoms has typically been observed in patients with positive anti-neural antibodies, but this case highlights a 78-year-old woman whose neurological symptoms improved after surgery for breast cancer despite negative antibody tests.
  • The patient’s ataxia was quantitatively assessed using the Scale for the Assessment and Rating of Ataxia (SARA), showing significant improvement post-surgery, suggesting that breast cancer treatment could benefit patients who are negative for anti-neural antibodies.
View Article and Find Full Text PDF
Article Synopsis
  • Knee osteoarthritis affects how people walk, particularly in older adults, and the use of wearable sensors for assessing gait in these patients has been insufficiently studied.
  • * The study involved 60 knee osteoarthritis patients and 20 healthy controls using shoes with embedded sensors while walking, collecting data to classify patient groups through machine learning techniques.
  • * Results showed that the sensors and machine learning could distinguish healthy individuals from patients, as well as classify different types of knee osteoarthritis with decent accuracy and sensitivity, offering a practical assessment method beyond laboratory environments.
View Article and Find Full Text PDF

A 44-year-old woman with autism spectrum disorder developed bulbar symptoms and generalized muscle weakness 7 months before referral. Six months before, she was administered glucocorticoid for liver involvement. During the course, while she presented alopecia, skin ulcers, and poikiloderma, hyperCKemia was observed only twice.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigated repeat expansion in patients with adult-onset cerebellar ataxia, focusing on the differences between Japanese and non-Japanese populations.
  • The researchers used nanopore sequencing to analyze samples from 460 Japanese patients and various control groups, finding that different repeat motifs (GCA in Japanese vs. GGA in non-Japanese) affect pathogenicity.
  • Ultimately, the study highlights how unique features of repeat expansion and genetic background contribute to the prevalence of the disease in different ethnic groups.
View Article and Find Full Text PDF

Oxide ion conductors are attractive materials because of their wide range of applications, such as solid oxide fuel cells. Oxide ion conduction in oxyhalides (compounds containing both oxide ions and halide ions) is rare. In the present work, we found that Sillén oxychlorides, BiTeLuOCl ( = 0, 0.

View Article and Find Full Text PDF

Patients with pseudobulbar palsy often present with velopharyngeal incompetence. Velopharyngeal incompetence is usually observed during expiratory activities such as speech and/or blowing during laryngoscopy. These patients typically exhibit good velopharyngeal closure during swallowing, which is dissociated from expiratory activities.

View Article and Find Full Text PDF
Article Synopsis
  • - A typical individual infected with HTLV-1 has over 10,000 different T cell clones, each containing a unique HTLV-1 provirus affecting host genome transcription and chromatin structure.
  • - Researchers investigated whether the negative effects on host transcription and chromatin loops were due to the presence of the provirus or its activity by analyzing T cells based on proviral expression.
  • - They discovered that while proviral transcription leads to abnormal transcription and splicing in adjacent genes, it actually suppresses the formation of abnormal chromatin loops, and reducing this transcription can restore normal chromatin interactions.
View Article and Find Full Text PDF

Background: An inertial measurement unit is small and lightweight, allowing patient measurements without physical constraints. This study aimed to determine the differences in kinematic parameters during gait using an insole with a single inertial measurement unit in healthy controls and on both sides in patients with knee osteoarthritis.

Methods: Twenty patients with knee osteoarthritis and 13 age-matched controls were included in this study.

View Article and Find Full Text PDF

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, or small vessel thromboembolic events. We present here a rare case of APS with repeated multiple cerebral infarctions in the same watershed area without visible arterial stenosis. A 53-year-old woman without a past medical history presented with a headache and numbness of the right fingers.

View Article and Find Full Text PDF

Introduction/aims: We have encountered patients with myasthenia gravis (MG) who exhibited palatal prolapse (PP) during nasal expiration in the supine position while awake. This may be an overlooked cause of dyspnea in MG patients. This study aimed to examine and describe the characteristics of MG patients with PP.

View Article and Find Full Text PDF