Decreased hippocampal serotonin 5HT expression in mesial temporal lobe of epilepsy patients.

Introduction: Mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) is a surgically remediable epilepsy with a relatively high prevalence and psychiatric comorbidities. Depressive disorders may occur in up to 25% of MTLE-HS patients suggesting a common molecular mechanism underlying both conditions.

Objective: To compare the gene expression comprising serotonin 5HT and 5HT, noradrenaline (NA) ADRA1A, and ADRA2A receptors in the hippocampus of MTLE-HS patients with and without major depression.