Structural alterations in scales of Capoeta capoeta (Güldenstädt, 1773) from heavy metal-contaminated river water.

Heavy metal pollution, especially in freshwater, is a serious problem for aquatic organisms and human health. In this study, the scales of Capoeta capoeta living in the Karasu River (Turkey), which is estimated to be contaminated with pollutants, especially heavy metals, were examined for structural anomalies. Two stations on the river were selected for this purpose.

Effect of different apical actions of new integrated endodontic motors on apical debris extrusion: An in vitro study.

The new generation endodontic motors can perform different kinematics when they reach a certain predetermined level thanks to the integrated apex locator system. These actions consist of apical reverse, apical slow down and apical stop. The aim of this study is to compare this action's effect on apical debris extrusion.

The Effect of Root Canal Preparation Size and Taper of Middle Mesial Canals on Fracture Resistance of the Mandibular Molar Teeth: An In Vitro Study.

Introduction: The aim of the present study was to investigate the influence of root canal preparation size and taper of middle mesial (MM) canals on fracture resistance of mandibular molars.

Methods: Fifty-five mandibular molar teeth having an MM canal were selected based on the cone-beam computed tomographic analysis. After the decoronation and distal root separation procedure, the lengths of the mesial roots were standardized to 13 mm.

The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.

This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets.

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells.

Study Question: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?

Summary Answer: Cyclophosphamide (alkylating agent) and cisplatin (alkylating like) impacted both primordial and pre-antral/antral follicles and both mitotic and non-mitotic granulosa cells, whereas the anti-metabolite cancer drug gemcitabine was detrimental only to pre-antral/antral follicles and mitotic non-luteinized granulosa cells.

What Is Known Already: It is already known that anti-metabolite cancer drugs are less detrimental to the ovary than alkylating and alkylating like agents, such as cyclophosphamide and cisplatin. This assumption is largely based on the results of clinical reports showing lower rates of amenorrhea in women receiving anti-metabolite agent-based regimens compared with those treated with the protocols containing an alkylating drug or a platinum compound.