Publications by authors named "Yagmur Bayindir"

Vasculitis in children represents a diverse group of diseases characterized by inflammation of blood vessels, which can lead to significant morbidity if not promptly recognized and managed. This review explores the epidemiology, pathophysiology, classification, and management of key pediatric vasculitides. Classification based on vessel size aids in diagnosis and treatment.

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  • The study tested the effectiveness of a Turkish version of a virtual pediatric gait examination (v-pGALS) in a large group of children aged 4-18 during May and June 2022.
  • It compared the findings of v-pGALS with traditional hands-on physical exams, finding that v-pGALS had high sensitivity (92.6%) and perfect specificity (100%) for identifying musculoskeletal issues.
  • Parents and patients reported little to no discomfort and found the duration of the v-pGALS examination acceptable, indicating it is a practical tool for assessing children's musculoskeletal problems.
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  • - The study focuses on Familial Mediterranean Fever (FMF), an autoinflammatory disease characterized by the activation of the pyrin inflammasome, potentially leading to a specific type of cell death called pyroptosis.
  • - Researchers analyzed plasma samples from 25 FMF patients, alongside 10 patients with PFAPA and 10 healthy controls, to investigate the cell-death mechanisms during FMF attacks and the attack-free period.
  • - Findings revealed that levels of specific proteins (sFasL and granzyme A) were significantly elevated during FMF attacks but returned to normal when the patient was attack-free, indicating a distinct inflammatory response not seen in the PFAPA group.
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Aims: To examine physical functions, activity, and participation level, and associated factors with participation in children with juvenile idiopathic arthritis (JIA) across the International Classification of Functioning Disability and Health-Children and Youth.

Methods: 49 children (Girl/Boy:28/21) aged between 7 and 18 years (Mean: 13.4 ± 3.

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Background: The aim of this study was to reveal the relationship between the health literacy (HL) levels of children with juvenile idiopathic arthritis (JIA) and their parents, and the general health status and physical performance of the children.

Methods: This study included 79 children aged 9-18 years with a diagnosis of JIA and one of their parents. HL levels were evaluated with the Turkish version of the Health Literacy for School-Aged Children and Turkish Health Literacy-32 (THL-32) for children and Adult Health Literacy Scale (AHLS) for their parents.

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  • The study focuses on adolescent female patients with Familial Mediterranean fever (FMF) to explore how menstruation may trigger their attacks and to propose a management strategy.
  • Out of 151 participants, 23.2% experienced menstruation-associated attacks, which had distinct features, such as fewer incidents of fever and arthritis than non-menstruation-associated attacks.
  • The findings suggest younger patients with higher dysmenorrhea rates are more likely to have menstruation-related FMF attacks, and various on-demand therapies, like colchicine and anti-inflammatory drugs, proved effective in managing these attacks.
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Objectives: The transition of adolescents and young adults (AYAs) from pediatric to adult-oriented healthcare may be affected by many factors, including the personal and cultural settings. We aimed to analyze the transition readiness and the factors affecting the transition success in rheumatology.

Methods: Patients older than 12 years were included in this prospective study.

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Objective: Our study was designed to investigate the reasons for starting the conventional disease-modifying anti-rheumatic drugs (DMARDs) and the variables that impact the response to DMARD treatment in oligoarticular juvenile idiopathic arthritis (JIA) patients.

Methods: Oligoarticular JIA patients (n = 187) were categorized into two groups: Group A consisted of patients who achieved remission with DMARD, and Group B comprised those who did not respond to DMARD therapy.

Results: DMARDs were initiated for various reasons: 68 (36.

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  • - The study aimed to establish and validate specific cutoff values for the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) to differentiate between various disease activity levels in children with systemic juvenile idiopathic arthritis.
  • - Researchers used data from 400 patients across multiple countries, applying different methods to determine these cutoffs, ensuring robust validation through comparison of physician assessments.
  • - The identified cutoffs were found to effectively separate inactive disease, minimal disease activity, moderate disease activity, and high disease activity, making them reliable for clinical use and research purposes.
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Introduction: This study aimed to assess the cultural adaptation, validity, and reliability of the Turkish version of the Juvenile Arthritis Quality of Life Questionnaire (JAQQ) in patients with juvenile idiopathic arthritis (JIA).

Methods: A total of 100 JIA patients (64% female), aged 9 to 18 years, participated in the study conducted at a tertiary care university hospital. The JAQQ was culturally adapted through a rigorous translation process and administered alongside established measures, including the Childhood Health Assessment Questionnaire (CHAQ), Juvenile Arthritis Biopsychosocial Questionnaire (JABQ), and Children's Depression Inventory (CDI).

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  • The study analyzed the use and switching patterns of biologic drugs in juvenile idiopathic arthritis (JIA) patients from January 2004 to July 2022, focusing on different disease subtypes.
  • Among 294 patients, the majority had systemic JIA, followed by oligoarticular and enthesitis-associated arthritis, with Anakinra being the most popular first-line treatment for systemic JIA.
  • The main reasons for switching biologics were difficulty with daily injections in systemic JIA patients and inadequate response in non-systemic JIA, with overall good responses and few side effects observed.
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Objectives: Macrophage activation syndrome (MAS) is a severe complication of systemic juvenile idiopathic arthritis (SJIA). We aimed to compare the characteristics of SJIA patients who developed MAS in the disease course to those who never experienced MAS.

Methods: Patients with SJIA were included.

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Objectives: We aimed to outline the demographic data, clinical spectrum, and treatment approach of sarcoidosis in a large group of patients and sought to figure out the variations of early-onset (EOS) and late-onset paediatric sarcoidosis (LOS).

Methods: The study followed a retrospective-descriptive design, with the analysis of medical records of cases diagnosed as paediatric sarcoidosis.

Results: Fifty-two patients were included in the study.

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Objectives: Colchicine forms the mainstay of treatment in FMF. Approximately 5-10% of FMF patients are colchicine resistant and require anti-IL-1 drugs. We aimed to compare the characteristics of colchicine-resistant and colchicine-responsive patients and to develop a score for predicting colchicine resistance at the time of FMF diagnosis.

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Objectives: There is no consensus on canakinumab treatment tapering and discontinuation strategies in colchicine-resistant FMF patients. In this study, we aimed to establish a treatment management and discontinuation protocol in paediatric FMF patients treated with canakinumab.

Methods: Fifty-eight FMF patients treated with canakinumab were included.

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  • Periodic fever syndromes (PFS) are autoinflammatory disorders marked by recurrent fevers and inflammation, with notable types including familial Mediterranean fever and cryopyrin-associated periodic syndrome.
  • Cardiovascular issues, particularly pericarditis, are common in PFS patients and assessing these risks should be integrated into their regular care.
  • Complications such as amyloidosis and ongoing inflammation can worsen heart health, highlighting the need for effective management of inflammation and related risk factors like obesity and diabetes.
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Objective: Children with suspicious complaints of rheumatic diseases are generally referred to a pediatric rheumatologist. We aimed to evaluate the profile of patients referred to the pediatric rheumatology unit and were not diagnosed with a rheumatic disease and to assess the impact of the coronavirus disease-2019 pandemic on referral complaints.

Materials And Methods: All new outpatients who applied to the pediatric rheumatology department between March 2019 and February 2021 and were not diagnosed with rheumatic disease were included.

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  • Cogan's syndrome (CS) is a rare disease that causes eye problems and hearing issues, often getting worse over time.
  • Two kids with CS were treated and one improved with a cochlear implant, while the other felt better after treatment.
  • A study found that most kids with CS had sudden hearing loss and eye symptoms, and doctors from different specialties should work together to help these patients.
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Objectives: Rice body (RB) formation is an uncommon inflammatory process seen in systemic disorders. In this study, we aimed to assess characteristic features of RBs in pediatric patients.

Method: We retrospectively evaluated pediatric patients who underwent joint/extremity magnetic resonance imaging.

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  • A study examined the experiences of seven children with Takayasu arteritis (TA) who were treated with biologics such as adalimumab or tocilizumab.
  • The patients, mostly young females, initially received steroids or combined treatments, but switched to biologics when their conditions improved.
  • Both biologics showed effectiveness in managing TA, but further research through controlled trials is necessary to compare their efficacy.
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Colchicine is the mainstay of treatment for familial Mediterranean fever. We investigated the frequency of leukopenia in 213 patients with familial Mediterranean fever treated with standard doses of colchicine (0.5-2.

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