Publications by authors named "Yafet Mamo"

Objective: Due to the COVID-19 pandemic, more peripheral blood stem cell (PBSC) allogeneic grafts are being frozen and infused thawed. Our objective was to study the influence of graft viability on engraftment outcome in patients treated with PBSCs.

Methods: Using trypan blue stain, we compared total nucleated cell (TNC) viability of both fresh and thawed grafts in allogeneic PBSCs.

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Fecal microbiota transplantation (FMT) is increasingly being performed for Clostridium difficile infection in solid organ transplant (SOT) patients; however, little is known about the potential pharmacokinetic or pharmacomicrobial effects this may have on tacrolimus levels. We reviewed the medical records of 10 SOT patients from September 2012-December 2016 who were taking tacrolimus at time of FMT for recurrent C. difficile infection.

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Article Synopsis
  • Fecal microbiota transplant (FMT) is shown to be safe and effective for treating recurrent Clostridium difficile infections (RCDI), with 82% of patients reporting no recurrence after a median follow-up of 22 months.
  • Many patients expressed a preference for FMT over antibiotics for future CDI recurrences, highlighting high satisfaction with the procedure.
  • However, those who experienced a recurrence had more antibiotic exposure post-FMT, suggesting a need for careful antibiotic use and potential strategies to enhance microbiome resilience.
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