Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures.

Cognitive impairment and depression are salient comorbidities of mesial temporal lobe epilepsy; it is still unclear whether this frequently drug resistant disease is a cause or consequence of hippocampal damage and its interplay with long-lasting seizure activity (; SE). Thus, a major therapeutic advance in this field is badly needed. We modeled enduring behavioral and electroencephalographic (EEG) seizures in mice by the intraperitoneal injection of kainic acid (KA), and measured the dynamics of the intracellular Ca signals in the hippocampal CA1 area by fiber photometry.

Engineering Atom-Scale Cascade Catalysis via Multi-Active Site Collaboration for Ampere-Level CO Electroreduction to C Products.

Electrochemical reduction of CO to value-added multicarbon (C) productions offers an attractive route for renewable energy storage and CO utilization, but it remains challenging to achieve high C selectivity at industrial-level current density. Herein, a MoCu single-atom alloy (SAA) catalyst is reported that displays a remarkable C Faradaic efficiency of 86.4% under 0.

Encapsulating phase change materials into melamine formaldehyde sponge assembled with polypyrrole modified halloysite nanotube for effective solar-thermal energy storage and solar-thermal-electric conversion.

Exploiting inexpensive composite phase change materials (PCMs) with comprehensive characteristics of high encapsulation efficiency, good leakage resistance, strong flexibility, high heat conductivity, and powerful light absorption is considerably imperative for their solar-thermal and solar-thermal-electric conversion. Herein, polypyrrole (PPy) modified halloysite (HNT/PPy) was assembled into the pores of melamine formaldehyde (MF) sponge to construct hierarchical porous structure (MHP), in which PPy serves as light absorber and heat conducting agent to consolidate the light absorption and thermal conductivity, while the interwoven HNT in MF not only acts as carrier to provide sufficient space for guaranteeing more PCMs' encapsulation, but also dramatically narrows MF's pore size and prevents PCMs' leakage. As expected, the MHP can encapsulate as high as 95 wt% of polyethylene glycol (PEG) with extremely high latent heat of 177.

Constructing core-shell phosphorus doped MnCoO@ZIS for efficient photocatalytic hydrogen production from water splitting.

Rational construction of core@shell heterostructured photocatalysts is the key to realize efficient hydrogen production from water splitting attributing to the accelerated photoinduced charges separation/transfer and enhanced light absorption ability. In this work, two-dimensional (2D) ZnInS (ZIS) nanosheets were in-situ grown on phosphorus doped MnCoO (P-MnCoO) nanospheres to construct P-MnCoO@ZIS heterostructured photocatalysts for efficient photocatalytic hydrogen production. The optimized 6 wt% P-MnCoO@ZIS composite presents remarkable photocatalytic hydrogen evolution rate of 4197 µmol g h (8 times of single ZIS) along with excellent cycling stability, which is comparable to most previous reported ZnInS-based or even noble-metal involved catalysts.

Sb nanoparticles embedded uniformly on the surface of porous carbon fibres for high-efficiency sodium storage.

Sb nanoparticles (∼50 nm) are embedded uniformly on the surface of carbon fibers (Sb NPs-SCFs) without scattered Sb NPs. The Sb NPs-CNFs anode exhibits excellent sodium storage, delivering a second cycle discharge capacity of 455.7 mA h g at 1.

Coordination Regulation Strategy in Fabricating BiS@CNFs Composites with Uniform Dispersion for Robust Sodium Storage.

To solve large volume change and low conductivity of BiS-based anodes, a coordination regulation strategy is proposed to prepare BiS nanoparticles dispersed in carbon fiber (BiS@CNF) composites. It has been discovered that introducing trimesic acid as a ligand can significantly improve the loading and dispersion of Bi in polyacrylonitrile fibers. The results exhibit that BiS nanoparticles of 200-300 nm are uniformly anchored on the superficial surface layer of CNFs, and BiS nanoparticles of about 20 nm are evenly dispersed in the interior of CNFs.

An Ecological Survey of Chiggers (Acariformes: Trombiculidae) Associated with Small Mammals in an Epidemic Focus of Scrub Typhus on the China-Myanmar Border in Southwest China.

Chiggers (chigger mites) are a group of tiny arthropods, and they are the exclusive vector of (Ot), the causative agent of scrub typhus (tsutsugamushi disease). Dehong Prefecture in Yunnan Province of southwest China is located on the China-Myanmar border and is an important focus of scrub typhus. Based on the field surveys in Dehong between 2008 and 2022, the present paper reports the infestation and ecological distribution of chiggers on the body surface of rodents and other sympatric small mammals (shrews, tree shrews, etc.

AGAMOUS-LIKE 24 senses continuous inductive photoperiod in the inflorescence meristem to promote anthesis in chrysanthemum.

During the floral transition, many plant species including chrysanthemum (Chrysanthemum morifolium) require continuous photoperiodic stimulation for successful anthesis. Insufficient photoperiodic stimulation results in flower bud arrest or even failure. The molecular mechanisms underlying how continuous photoperiodic stimulation promotes anthesis are not well understood.

Phosphorus and sulfur co-doped nickel molybdate with rich-oxygen vacancies for efficient water splitting.

The rational design of high-performance electrocatalysts is essential for promoting the industrialization of electrocatalytic water-splitting technology. Herein, phosphorus and sulfur co-doped nickel molybdate with rich-oxygen vacancies (P, S-NiMoO) was prepared as an efficient bifunctional self-supporting water-splitting catalyst from the perspective of enhancing the conductivity and optimizing the electronic configurations. The incorporation of P, S and oxygen vacancies greatly enhances the conductivity and charge-transfer efficiency of NiMoO.

Element Screening of High-Entropy Silicon Anodes for Superior Li-Storage Performance of Li-Ion Batteries.

The high-entropy silicon anodes are attractive for enhancing electronic and Li-ionic conductivity while mitigating volume effects for advanced Li-ion batteries (LIBs), but are plagued by the complicated elements screening process. Inspired by the resemblances in the structure between sphalerite and diamond, we have selected sphalerite-structured SiP with metallic conductivity as the parent phase for exploring the element screening of high-entropy silicon-based anodes. The inclusion of the Zn in the sphalerite structure is crucial for improving the structural stability and Li-storage capacity.

p-d Orbital Hybridization Induced by Asymmetrical FeSn Dual Atom Sites Promotes the Oxygen Reduction Reaction.

With more flexible active sites and intermetal interaction, dual-atom catalysts (DACs) have emerged as a new frontier in various electrocatalytic reactions. Constructing a typical p-d orbital hybridization between p-block and d-block metal atoms may bring new avenues for manipulating the electronic properties and thus boosting the electrocatalytic activities. Herein, we report a distinctive heteronuclear dual-metal atom catalyst with asymmetrical FeSn dual atom sites embedded on a two-dimensional CN nanosheet (FeSn-CN), which displays excellent oxygen reduction reaction (ORR) performance with a half-wave potential of 0.

Silence of Aminopeptidase N 2 gene reveals the trade-offs for acquiring Cry1Ac resistance in Plutella xylostella.

Bacillus thuringiensis (Bt) is widely used as a biopesticide worldwide. To date, at least eight pest species have been found to be resistant to Bt in the field. As the first pest that was reported having resistance to Bt in the field, considerable research has been done on the mechanisms of Bt resistance in Plutella xylostella.

Transcription Cofactor CsMBF1c Enhances Heat Tolerance of Cucumber and Interacts with Heat-Related Proteins CsNFYA1 and CsDREB2.

Multiprotein bridging factor 1 (MBF1) is a very important transcription factor (TF) in plants, whose members influence numerous defense responses. Our study found that MBF1c in Cucurbitaceae was highly conserved. expression was induced by temperature, salt stress, and abscisic acid (ABA) in cucumber.

Exploration of Gene Therapy for Alport Syndrome.

Alport syndrome is a hereditary disease caused by mutations in the genes encoding the alpha 3, alpha 4, and alpha 5 chains of type IV collagen. It is characterized by hematuria, proteinuria, progressive renal dysfunction, hearing loss, and ocular abnormalities. The main network of type IV collagen in the glomerular basement membrane is composed of α3α4α5 heterotrimer.

Molecular detection of Cryptosporidium in Alpine musk deer (Moschus chrysogaster) in Gansu Province, Northwest China.

Cryptosporidium spp. are protozoa commonly found in domestic and wild animals. Limited information is available on Cryptosporidium in deer worldwide.

A sensing label or gel loaded with an NIR emission fluorescence probe for ultra-fast detection of volatile amine and fish freshness.

A simple benzopyran-based fluorescence probe DCA-Apa detection of volatile amine has been synthesized. DCA-Apa can recognize volatile amines by dual channel mode (changing from blue to light yellow in sunlight, and from weak pink to orange under 365 nm) in pure water system. DCA-Apa has the advantages of ultra-fast response (∼6 s), NIR emission (655 nm), and a good fluorescence response for many amines.

Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation.

COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, and specific treatments are lacking. Here, we constructed a transgenic Alport syndrome mouse model by generating a mutation (Col4a3 p.

Interface engineering of three-phase nickel-cobalt sulfide/nickel phosphide/iron phosphide heterostructure for enhanced water splitting and urea electrolysis.

Rational designing efficient transition metal-based multifunctional electrocatalysts is highly desirable for improving the efficiency of hydrogen production from water cracking. Herein, a self-supported three-phase heterostructure electrocatalyst of nickel-cobalt sulfide/nickel phosphide/iron phosphide (CoNiS-NiP-FeP) was prepared by a two-step gas-phase sulfurization/phosphorization strategy. The heterostructure in CoNiS-NiP-FeP provides a favorable interfacial environment for electron transfer and synergistic interaction of multiphase active components, while the introduced electronegative P/S not only serves as a carrier for proton capture in the hydrogen evolution reaction (HER) process but also promotes the metal-electron outflow, which in turn accelerates the generation of high-valent Ni species to enhance the catalytic activity of oxygen evolution reaction (OER) and urea oxidation reaction (UOR).