Differences in Cpg Island Distribution Between Subgenotypes of the Hepatitis B Virus Genotype.

BACKGROUND Hepatitis B virus (HBV) genotypes show genomic variations, resulting in different CpG islands in each HBV genotypes or subgenotype. This study aimed to establish reference sequences for each HBV subgenotype of A-H genotypes and to analyze the characteristics of the CpG islands. MATERIAL AND METHODS There were 3,037 retrieved whole-genome sequences of HBV genotypes A-H from GenBank, 28 subgenotype reference sequences were established for these genotypes.

Postoperative adjuvant chemo (embolization) therapy for hepatocellular carcinoma with portal vein tumor thrombosis.

Background: The present meta-analysis was aimed to evaluate the effects of postoperative adjuvant chemotherapy/transarterial chemoembolization (TACE) on the survival/disease-free survival (DFS) rate in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT).

Methods: The relevant trials were collected using a database search of MEDLINE, Embase, Cochrane Library, Web of Science, ScienceDirect, the China Journal Full-text Database, and the National Institute of Health Clinical Trials Database. The 1-, 3-, and 5-year survival/DFS rates were considered to be the primary end points.

Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes.

Purpose: GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.

Methods: During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.

MiR-21 Suppresses Anoikis through Targeting PDCD4 and PTEN in Human Esophageal Adenocarcinoma.

Anoikis is a form of apoptosis induced upon cell detachment from extracellular matrix. It has been determined that acquisition of resistance to anoikis is a critical step for tumor cell metastasis. MiR-21, the most prominent oncomiR, plays an important role in tumor progression.

Observation of local cardiac electrophysiological changes during off-pump coronary artery bypass grafting using epicardial mapping.

Objectives: At present, there is no effective method of evaluating the electrophysiological changes in cardiac myocytes during off-pump coronary artery bypass grafting (OPCAB). Therefore, we preliminarily explored the relationship between electrophysiological characteristics and the changes in cardiac function of 24 patients undergoing OPCAB.

Methods: We used the CARTO3 system for epicardial electrophysiological mapping before surgery, during left anterior descending branch anastomosis, diagonal branch anastomosis and after surgery for 24 patients undergoing OPCAB.

Risk Factors of Vulvovaginal Candidiasis among Women of Reproductive Age in Xi'an: A Cross-Sectional Study.

To explore risk factors of vulvovaginal candidiasis (VVC) among women of reproductive age in Xi'an district and then to offer reference for clinical prevention and treatment of VVC. Patients from the outpatient department of gynecology and obstetrics in the First Affiliated Hospital of Xi'an Jiaotong University from June 2016 to May 2017 were recruited strictly according to the inclusion and exclusion criteria. Participants diagnosed as simple VVC were assigned to the case group, while women who underwent routine gynecological examination and had normal vaginal microflora were assigned to the control group.

Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.

Aim: Available data concerning the association between RAD51 135G/C (rs1801320) polymorphism and the risk of 3 common gynecological cancers still could not reach a consensus. Thus, we conducted a meta-analysis to explore the relationship.

Methods: Several electronic databases and bibliographies of relevant articles were screened to identify the studies up to July 2017.

Design of Hetero-Nanostructures on MoS Nanosheets To Boost NO Room-Temperature Sensing.

Molybdenum disulfide (MoS), as a promising gas-sensing material, has gained intense interest because of its large surface-to-volume ratio, air stability, and various active sites for functionalization. However, MoS-based gas sensors still suffer from low sensitivity, slow response, and weak recovery at room temperature, especially for NO. Fabrication of heterostructures may be an effective way to modulate the intrinsic electronic properties of MoS nanosheets (NSs), thereby achieving high sensitivity and excellent recovery properties.

Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis.

Introduction: The results of the earlier published studies on the association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma (HCC) risk are inconclusive. Hence, we performed this meta-analysis to evaluate the relationship between KIF1B (rs17401966) polymorphism and HCC risk.

Methods: Databases including PubMed, Web of Science and the Cochrane Library and bibliographies of relevant papers were screened to identify relevant studies published up to March 25, 2018.

Cellular Senescence-Inducing Small Molecules for Cancer Treatment.

Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported.

Effect of vanadium released from micro-arc oxidized porous Ti6Al4V on biocompatibility in orthopedic applications.

MAO-treated porous Ti6Al4V holds enormous potential for use in orthopedic implants due to their excellent biocompatibility and favourable mechanical strength. However, the effects on the V ion accumulation and release following the MAO-treated Ti6Al4V remain undetermined. The aim of the present study was to assess the effects of Vanadium on biocompatibility.

Bioaugmentation with Clostridium tyrobutyricum to improve butyric acid production through direct rice straw bioconversion.

One-pot bioconversion is an economically attractive biorefinery strategy to reduce enzyme consumption. Direct conversion of lignocellulosic biomass for butyric acid production is still challenging because of competition among microorganisms. In a consolidated hydrolysis/fermentation bioprocessing (CBP) the microbial structure may eventually prefer the production of caproic acid rather than butyric acid production.

Effects of deoxynivalenol exposure on cerebral lipid peroxidation, neurotransmitter and calcium homeostasis of chicks in vivo.

During current research, the effects of deoxynivalenol (DON) exposure on cerebral lipid peroxidation, neurotransmitter secretion and calcium homeostasis in chicks were evaluated. One hundred and twenty Hailan chicks (male, 1-day-old) were randomly divided into four groups. Chicks in low, medium and high dose groups were fed with 0.

Maximum cadmium limits establishment strategy based on the dietary exposure estimation: an example from Chinese populations and subgroups.

Dietary exposure to cadmium (Cd) in the Chinese population is currently a public health concern. China's national standard for maximum limits (MLs) of Cd in foods needs to be assessed. The objective of this research is to estimate the impacts of different Cd MLs intakes from selected foods and food groups and to provide scientific evidence for ML establishment.

In situ coating nickel organic complexes on free-standing nickel wire films for volumetric-energy-dense supercapacitors.

A self-free-standing core-sheath structured hybrid membrane electrodes based on nickel and nickel based metal-organic complexes (Ni@Ni-OC) was designed and constructed for high volumetric supercapacitors. The self-standing Ni@Ni-OC film electrode had a high volumetric specific capacity of 1225.5 C cm at 0.

The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma.

The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and plays an important role in various pathological and physiological processes. In many chronic diseases, for example cancer, PTP is a potential therapeutic target for cancer treatment. In the last two decades, dozens of PTP inhibitors which specifically target individual PTP molecules were developed as therapeutic agents.

Synthesis of EU-1/ZSM-48 Co-Crystalline Zeolites from High-Silica EU-1 Seeds: Tailoring Phase Proportions and Promoting Long Crystalline-Phase Stability.

A facile, specific, seed-assisted strategy for the synthesis of EU-1/ZSM-48 co-crystalline zeolites in the presence of hexamethonium ions (HM ) has been developed. EU-1/ZSM-48 co-crystalline zeolites with various phase proportions, with EU-1 in the range of 25 wt %-86 wt %, were obtained by adding high-silica EU-1 seeds (SiO /Al O ratio of 300) and adjusting the synthesis parameters. Not only can the phase proportions of EU-1/ZSM-48 co-crystalline zeolites be controlled, but also the stability period for co-crystallization of the two phases can be extended through varying the amount of EU-1 seeds and the HM template.

Hyper-production of butyric acid from delignified rice straw by a novel consolidated bioprocess.

A novel consolidated bioprocess for hyper-production of butyric acid from delignified rice straw without exogenous enzymes involved was developed by co-fermentation of Clostridium thermocellum ATCC 27405 and C. thermobutyricum ATCC 49875. Feasibility of the consolidated bioprocess was approved by batch fermentations, with the optimum pH of 6.

Association between rs11200014, rs2981579, and rs1219648 polymorphism and breast cancer susceptibility: A meta-analysis.

Background: Research on the polymorphism of breast cancer (BC) helps to search the BC susceptibility gene for mass screening, early diagnosis, and gene therapy, which has become a hotspot in BC research field. Previous studies have suggested associations between rs11200014, rs2981579, and rs1219648 polymorphisms and cancer risk. The aim of this study was to evaluate the relationship between rs11200014, rs2981579, and rs1219648 polymorphism and BC risk.

Linear humidity response of carbon dot-modified molybdenum disulfide.

Molybdenum disulfide (MoS)-based humidity sensors suffer from low sensitivity and long response time. Herein, this problem has been effectively solved by modifying MoS nanosheets using carbon dots (CDs) with abundant functional groups via a convenient and facile hydrothermal method. The mechanism for the enhanced humidity response of CD-modified MoS has been proposed through the characterization of physical and chemical properties of the as-prepared composites.

Controlled growth of vertically aligned ultrathin InS nanosheet arrays for photoelectrochemical water splitting.

This paper reports a facile solvothermal method for the in situ growth of vertically aligned InS nanosheet arrays (NSAs) on fluorine-doped tin oxide substrates. The as-synthesized two-dimensional graphene-like InS nanosheets show an ultrathin thickness down to 3.7 nm consisting of the duodenary interplanar spacing of the (222) plane and a tunable bandgap varying from 2.

Probability of cancer in high-risk patients predicted by the protein-based lung cancer biomarker panel in China: LCBP study.

Background: The authors built a model for lung cancer diagnosis previously based on the blood biomarkers progastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), and cytokeratin 19 fragment (CYFRA21-1). In the current study, they examined whether modification of the model to include relevant clinical information, risk factors, and low-dose chest computed tomography screening would improve the performance of the biomarker panel in large cohorts of Chinese adults.

Methods: The current study was a large-scale multicenter study (ClinicalTrials.

The clinical utility and outcomes of microwave ablation for colorectal cancer liver metastases.

In recent years, the microwave ablation (MWA) has been reported to play an important role in the treatment of patients with colorectal liver metastases (CRLM). In this work, 62 cases of patients who received MWA for liver metastases from colon or rectal cancer between Jan 2012 and Jan 2014 were enrolled in this trial. 28 underwent MWA, and 34 were treated with liver resection as control.

Cobalt Doping To Boost the Electrochemical Properties of Ni@Ni S Nanowire Films for High-Performance Supercapacitors.

Metal sulfides have aroused great interest for energy storage. However, their low specific capacities and inferior rate capabilities hinder their practical applications. In this work, a facile cobalt-doping process is used to boost the electrochemical performance of Ni@Ni S core-sheath nanowire film electrodes for high-performance electrochemical energy storage.