Publications by authors named "Yaelis Rivas"
Article Synopsis
- This study focuses on a new type of cancer vaccine that uses a specific protein (SPD-gp100-CD40L) to better target tumor-associated antigens to dendritic cells (DC), which play a crucial role in activating the immune response.
- The SPD-gp100-CD40L protein combines the melanoma tumor antigen gp100 with CD40L, allowing for better aggregation of CD40 on the DC surface, which enhances activation and signaling.
- In experiments with a melanoma model, the DNA vaccination combining SPD-gp100-CD40L with other plasmids (IL-12p70 and GM-CSF) led to improved survival rates and reduced tumor growth compared to separate expressions of the proteins.
Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyond the trimeric state (multi-trimerization) for optimal biological function.
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