The study investigates how insulin resistance and low HDL levels may contribute to asthma-related issues in urban adolescents and examines systemic inflammation as a potential link.
Research involved analyzing different immune cell responses and monocyte types in 168 adolescents, including those with and without asthma, to see how these factors correlate with insulin resistance and pulmonary function.
Findings revealed that obese adolescents with asthma had a higher Th1/Th2 immune response, which correlated with insulin resistance, while specific monocyte types and HDL levels were associated with various asthma severity measures and lung function metrics.