Publications by authors named "Yael Peled"
The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Listing Criteria for Heart Transplantation: A 10-year Update." The document aims to provide tools to help integrate the numerous variables involved in evaluating patients for transplantation, emphasizing updating the collaborative treatment while waiting for a transplant. There have been significant practice-changing developments in the care of heart transplant recipients since the publication of the International Society for Heart and Lung Transplantation (ISHLT) guidelines in 2006 and the 10-year update in 2016.
View Article and Find Full Text PDFContinued circulation of severe acute respiratory syndrome coronavirus 2 has driven the selection of variants with improved ability to escape preexisting vaccine-induced responses, posing a persistent threat to heart transplant recipients (HTRs). The immunogenicity and safety of the updated XBB.1.
View Article and Find Full Text PDFThe study aim was to determine caregiver interest and planned utilization of pharmacogenomic (PGx) results for their child with Prader-Willi syndrome. Caregivers consented to PGx testing for their child and completed a survey before receiving results. Of all caregivers (n = 48), 93.
View Article and Find Full Text PDFBackground: The safety and impact of sodium glucose transporter 2 inhibitors (SGLT2-I) in patients with left ventricular assist devices (LVAD) are unknown.
Methods: A retrospective analysis of all consecutive patients who underwent LVAD Heart Mate 3 (HM3) implantation at a single medical center and received SGLT2-I therapy following surgery was conducted. LVAD parameters, medical therapy, laboratory tests, echocardiography, and right heart catheterization (RHC) study results were recorded and compared before and after initiation of SGLT2-I.
Dip-pen nanolithography (DPN) is a powerful and unique technique for precisely depositing tiny nano-spherical cap shapes (nanoclusters) onto a desired surface. In this study, a meta-chemical surface (MCS; a pattern with advanced features) is developed by DPN and applied to electrochemical lead sensing, yielding a calibration curve in the ppb range. An ink mixture of PMMA and NTPH (which binds to Pb (II), as supported by DFT calculations) is patterned over a Pt surface.
View Article and Find Full Text PDFTwo negatives make a positive: Maximizing heart procurement in adult congenital heart disease.
J Heart Lung Transplant
November 2023
Background: Defining immune correlates of protection against COVID-19 is pivotal for optimizing the use of COVID-19 vaccines, predicting the impact of novel variants on clinical outcomes, and advancing the development of immunotherapies and next-generation vaccines. We aimed to identify vaccine-induced immune correlates of protection against COVID-19-related hospitalizations in a highly vaccinated heart transplant (HT) cohort.
Methods: In a case-control study of HT recipients vaccinated with the BNT162b2 vaccine, patients were prospectively assessed for vaccine-induced neutralization of the wild-type virus, and the Delta and Omicron BA.
Despite advances in pharmacological treatment of chronic heart failure (HF) as well as utilization of mechanical assist devices, long-term morbidity and mortality of HF patients remain high and many of these patients progress to end-stage HF. Heart transplantation has become the treatment of choice for selected patients with end-stage HF. However, challenges still exist.
View Article and Find Full Text PDFIn 2022, the antigenically divergent SARS-CoV-2 omicron variants (BA.1, BA.2, BA.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the outcomes of 1,987 diabetic patients hospitalized for non-ST elevation myocardial infarction (NSTEMI) or unstable angina (UA) who underwent either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) between 2000 and 2016.
- Results indicated that while no significant differences in mortality were observed at 2 years between CABG and PCI, CABG showed a significant survival advantage after 2 years of follow-up.
- The findings suggest that CABG may lead to better long-term outcomes for these diabetic patients, highlighting the need for more prospective randomized studies to refine treatment guidelines.
Transplanting COVID-19 positive donors: Expanding our experience to widen the donor pool.
J Heart Lung Transplant
October 2022
Article Synopsis
- The Norton score is a scale used to assess frailty, which is linked to complications and mortality in hospitalized patients, especially those undergoing aortic valve replacement (AVR).
- In a study of 1,469 patients who underwent AVR between 2004 and 2020, it was found that patients with a low Norton score (<18) had significantly higher in-hospital mortality rates compared to those with a high score (≥18).
- The Norton score effectively predicted both short-term (1-year) and long-term (10-year) mortality, suggesting it should be used as a key risk assessment tool for patients undergoing AVR.
Article Synopsis
- This study examines the impact of renal function on mortality risk in patients undergoing coronary artery bypass grafting (CABG) using various eGFR formulas from a cohort of 3,744 patients between 2004 and 2020.
- Results indicate that the Mayo eGFR formula yields the highest mean values, classifying more patients as having normal renal function compared to others, and shows a strong correlation with mortality prediction.
- The study concludes that the Mayo formula appears to be the most effective in assessing mortality risks, as it identifies fewer patients with renal dysfunction while providing a more accurate prognosis than other eGFR formulas.
Fourth BNT162b2 vaccination neutralization of omicron infection after heart transplantation.
J Heart Lung Transplant
September 2022
We investigated changes in receptor-binding domain IgG and neutralizing antibodies against the omicron and delta variants, vs the wild-type virus, in response to a fourth BNT162b2 dose in 90 heart transplant (HT) recipients. The fourth dose induced anti-RBD IgG antibodies and a higher neutralization efficiency against the wild-type virus and the variants; however, neutralization efficiency against the omicron variant was lower than that against the delta variant (the latter demonstrating efficacy similar to that against the wild-type virus). Notably, while IgG anti-RBD antibodies were detectable in >80% of the HT recipients, only about half demonstrated neutralization efficiency against the omicron variant.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the immune response durability in heart transplant recipients after receiving a 3-dose BNT162b2 vaccination, focusing on variant-specific neutralization and T-cell responses over a 6-month period.
- Results indicated that while neutralizing activity against the wild-type and delta variants remained relatively high after 6 months, the response to the omicron variant was significantly lower.
- Despite a decline in neutralization over time, the third dose led to a lasting T-cell response, suggesting ongoing protection against some variants of SARS-CoV-2.
Article Synopsis
- The study focuses on hypertrophic cardiomyopathy with reduced ventricular function (HCMr), which is distinct from typical heart failure associated with preserved ejection fraction.
- A registry of 1,328 HCM patients was analyzed, revealing that 2.8% had HCMr at the start, and 3.5% developed it during a 9-year follow-up, with various factors like younger age and arrhythmia linked to its onset.
- Genetic testing showed that 72% of 53 patients with HCMr had pathogenic variants, especially in myosin binding protein C, and those with HCMr faced higher risks of advanced heart failure treatments like VAD or transplantation.
Language is a social determinant of health, no less so in the case of Latinx persons, who make up the second largest ethnic group in the United States. In US health care, language and linguistic difference are often conceived in discrete, instrumental, and monolithic terms. This article characterizes this conception of language as administrative logic, which is in sharp contrast to language conceived as a richly complex, heterogeneous, communally lived human experience.
View Article and Find Full Text PDFArticle Synopsis
- This study evaluated the impact of different tricuspid annuloplasty ring types on outcomes for patients undergoing surgery for left-sided valvular diseases, focusing on recurrence of significant tricuspid regurgitation (TR).
- The research included 781 patients, comparing outcomes between those who received flexible bands and those who received rigid rings, with similar rates of early and long-term mortality and minimal differences in reoperation rates.
- The findings indicate that the type of ring used (rigid vs. flexible) does not significantly affect long-term TR recurrence; instead, patient-specific factors and left-sided heart conditions were more predictive of outcomes.
Objectives: Contemporary data on the prognostic impact of pre-existing left or right bundle branch block on clinical outcomes after aortic valve (AV) replacement are limited. The aim of this study was to evaluate the impact of pre-existing bundle branch block on clinical outcomes in patients undergoing AV replacement.
Methods: Data from patients who underwent AV replacement surgery between 2004 and 2020 were obtained from our departmental database.
Article Synopsis
- This study evaluated the effectiveness of the SYNTAX score II in predicting outcomes for patients with left main and/or 3-vessel coronary artery disease who underwent revascularization.
- Out of 1,112 patients, those with high SYNTAX scores showed significantly higher 30-day and six-year mortality rates compared to those with lower scores, with each unit increase correlating to a higher risk of death.
- The research concluded that SYNTAX score II is a valuable tool for assessing risk in patients with multivessel disease, improving predictions of long-term mortality when combined with standard prognostic factors.