Enteropathogenic infection co-elicits lysosomal exocytosis and lytic host cell death.

Enteropathogenic (EPEC) infection is a significant cause of gastroenteritis, mainly in children. Therefore, studying the mechanisms of EPEC infection is an important research theme. EPEC modulates its host cell life by injecting via a type III secretion machinery cell death modulating effector proteins.

Topology and function of translocated EspZ.

EspZ and Tir are essential virulence effectors of enteropathogenic (EPEC). EspZ, the second translocated effector, has been suggested to antagonize host cell death induced by the first translocated effector, Tir (translocated intimin receptor). Another characteristic of EspZ is its localization to host mitochondria.