Publications by authors named "Yael Houri-Hadad"
Article Synopsis
- T cell antigen receptor zeta chain down-regulation and decreased T cell function occur in cancer and autoimmune/infectious diseases, but the reasons for this are not fully understood.
- Sustained exposure to antigens and chronic inflammation may trigger these changes.
- Experiments on mice show that prolonged exposure to bacterial antigens can lead to zeta chain down-regulation and impaired T cell function, suggesting this response may help prevent harmful excessive immune reactions, but also potentially weaken responses against chronic diseases.
