Estimation of LDL Particle Size Using Lipid Indices: A Population-Based Study of 1578 Schoolchildren.

Background: Low-density lipoprotein (LDL) is atherogenic and LDL particles are reduced in diameter in the presence of insulin resistance, forming small, dense LDL. This study was conducted to assess the relationship between commonly used lipid indices and LDL particle size and furthermore to clarify the best surrogate lipid markers that could conveniently be used to estimate LDL particle size in children.

Methods: We determined LDL particle diameter by gradient gel electrophoresis in 1578 children aged 10-12 years.