Meta-Analysis of Efficacy and Safety of Karelizumab Combined with Apatinib in the Treatment of Advanced Gastric Cancer.

Objective: To systematically evaluate the clinical efficacy and safety of karelizumab combined with apatinib in the treatment of advanced gastric cancer.

Methods: The published databases were searched by computer, Chinese: China Biomedical Literature Database (CBM), Wanfang Journal Database, China national knowledge infrastructure (CNKI), and China Science and Technology Journal Database (VIP); English: Embase, Cochrane library, and PubMed. The search time is from the establishment of the database to May 2022, and clinical randomized controlled trials (RCT) with advanced gastric cancer as the research object and karelizumab combined with apatinib as the research variables are collected.

Structural and Interfacial Engineering of NiP/FeO Porous Nanosheet Arrays for Efficient Oxygen Evolution Reaction.

Rational design of transition-metal phosphide (TMPs)-based electrocatalysts can effectively promote oxygen evolution reaction (OER). Herein, the novel efficient NiP/FeO porous nanosheets arrays supported on Ni foam (NiP/FeO/NF) as alkaline OER catalysts were synthesized using structural and interfacial engineering. The three-dimensional (3D) porous hierarchical structure of NiP/FeO/NF provides abundant active sites for OER and facilitates the electrolyte diffusion of ions and O liberation.

Enhanced activity promoted by amorphous metal oxyhydroxides on CeO for alkaline oxygen evolution reaction.

Herein, we demonstrate a direct growth of amorphous metal oxyhydroxide (AMO) attached on CeO by a galvanic replacement mechanism as advanced oxygen evolution reaction (OER) catalyst. In this unique structure, the CeO substrate not only offers high specific surface area for the formation of AMO, but also provides high conductivity, guaranteeing the promoted electron transfer for the catalytic reaction. In addition, the AMO on the surface of the CeO exposes abundant active sites for the OER.

Rational interface engineering of CuS-CoO/CF enhances oxygen evolution reaction activity.

Interface engineering is the most direct and efficient way to enhance the oxygen evolution reaction (OER) activity of transition-metal sulfides (TMSs). However, present methods of engineering nano-interfaces remain to be improved. Here, we present a nitrate-pyrolysis method to create a sulfide-oxide interface on Cu2S for the first time.

Ultrathin Mn Doped Ni-MOF Nanosheet Array for Highly Capacitive and Stable Asymmetric Supercapacitor.

In this study, we demonstrate that an Mn-doped ultrathin Ni-MOF nanosheet array on nickel foam (Mn -Ni-MOF/NF) serves as a highly capacitive and stable supercapacitor positive electrode. The Mn -Ni-MOF/NF shows an areal capacity of 6.48 C cm (specific capacity C: 1178 C g ) at 2 mA cm in 6.

Pyrolysis of a self-supported dodecyl sulfate anion-intercalated Co(OH) nanosheet with enlarged amorphous phase content towards enhanced activity for alkaline water oxidation.

Highly active electrocatalysts made of earth-abundant elements are vital for efficient and cost-effective energy storage and conversion systems. In this communication, we report the further amorphization of a solvothermally synthesized dodecyl sulfate anion-intercalated cobalt hydroxide nanosheet array on nickel foam (DS-Co(OH)2/NF) via pyrolysis. Owing to the greatly enlarged interlayer distance of the DS-Co(OH)2/NF precursor (2.

In Situ Hydrothermal Growth of TiO Nanoparticles on a Conductive TiCT MXene Nanosheet: A Synergistically Active Ti-Based Nanohybrid Electrocatalyst for Enhanced N Reduction to NH at Ambient Conditions.

The traditional power-wasting Haber-Bosch process still dominates industrial NH production. Recent years witnessed the rapid development of an electrochemical N reduction reaction (NRR) because of its environmentally benign and sustainable feature. Here, we demonstrate the first utilization of a TiCT MXene nanosheet as both the precursor and conductive substrate toward the in situ hydrothermal growth of TiO nanoparticles.

A self-supported hierarchical Co-MOF as a supercapacitor electrode with ultrahigh areal capacitance and excellent rate performance.

Metal-organic frameworks (MOFs) have emerged as attractive electrode materials for applications in energy storage and conversion, owing to their high porosity and surface area. In this communication, we report a hierarchically structured Co-MOF supported on nickel foam (Co-MOF/NF) serving as a high-performance electrode material for supercapacitors. The as-obtained Co-MOF/NF exhibits an ultrahigh areal specific capacitance of 13.

Hierarchical three-dimensional manganese doped cobalt phosphide nanowire decorated nanosheet cluster arrays for high-performance electrochemical pseudocapacitor electrodes.

Ternary metal phosphides with a self-assembled hierarchical nanostructure are promising electrode materials for energy storage and conversion, due to the unique architecture and synergistic effects in bimetallic nanostructures. In this communication, we demonstrate hierarchical Mn-doped cobalt phosphide nanowire decorated nanosheet cluster arrays with robust adhesion on Ni foam (Mn-CoP/NF) as a binder-free electrode for supercapacitors. Such a 3D electrode exhibits boosted areal specific capacitance over that for a single metal counterpart, with the accomplishment of 8.

Aggregation-induced phosphorescence enhancement of Mn-doped ZnS quantum dots: the role of dot-to-dot distance.

Assembled nanoparticles promote many applications in optics due to their instinct properties. The aggregation-induced phosphorescence enhancement (AIPE) of Mn-doped ZnS quantum dots (QDs) is widely used in biosensing, but the mechanism of such an enhancement is still unproven. This study explores the mechanism of the interesting finding of AIPE of Mn-doped ZnS QDs.

Hierarchical CuCoS nanoarrays for high-efficient and durable water oxidation electrocatalysis.

It is highly attractive to design and develop earth-abundant electrocatalysts toward high-efficiency water oxidation electrocatalysis in alkaline media. In this communication, we report the in situ hydrothermal sulfidization preparation of a hierarchical CuCoS nanoarray on copper foam (CuCoS/CF) from its CuCo-hydroxide nanowire array precursor. When used as a 3D catalyst electrode for water oxidation, the as-prepared CuCoS/CF is superior in catalytic activity, demanding overpotentials of only 259 and 295 mV to achieve 60 and 100 mA cm in 1.

Anion-exchange synthesis of a nanoporous crystalline CoBO nanowire array for high-performance water oxidation electrocatalysis in borate solution.

Developing nanoporous nanoarray electrocatalysts for efficient water oxidation in environmentally benign media is highly desired but still remains a key challenge. In this communication, we report the fabrication of a nanoporous crystalline CoBO nanowire array on Ti mesh (CoBO/TM) from a Co(OH)F nanowire array on Ti mesh (Co(OH)F/TM) via an anion-exchange reaction. As a three dimensional (3D) catalyst electrode for water oxidation, CoBO/TM exhibits superior catalytic activity and needs an overpotential of only 446 mV to drive a geometrical catalytic current density of 10 mA cm in 0.

Self-Templating Construction of Hollow Amorphous CoMoS Nanotube Array towards Efficient Hydrogen Evolution Electrocatalysis at Neutral pH.

Environmentally friendly electrochemical hydrogen production needs the development of earth-abundant catalyst materials for the hydrogen evolution reaction with high activity and durability at neutral pH. In this work, the self-templating construction of a hollow amorphous CoMoS nanotube array on carbon cloth (CoMoS NTA/CC) is reported, using hydrothermal treatment of a Co(OH)F nanowire array on CC in (NH ) MoS solution. When used as a 3D electrode for hydrogen evolution electrocatalysis, the resulting CoMoS NTA/CC demonstrates superior catalytic activity and strong long-term electrochemical durability in 1.

Homologous Catalysts Based on Fe-Doped CoP Nanoarrays for High-Performance Full Water Splitting under Benign Conditions.

The design and development of earth-abundant electrocatalysts for efficient full water splitting under mild conditions are highly desired, yet remain a challenging task. A homologous Fe-doped Co-based nanoarray incorporating complementary catalysts is shown to effect high-performance and durable water splitting in near-neutral media. Iron-doped cobalt phosphate borate nanoarray on carbon cloth (Fe-Co-Pi-Bi/CC) derived from iron-doped cobalt phosphide on CC (Fe-CoP/CC) through oxidative polarization behaves as a highly active bimetallic electrocatalyst for water oxidation with an overpotential of 382 mV to afford a catalytic current density of 10 mA cm in 0.

Bimetallic Nickel-Substituted Cobalt-Borate Nanowire Array: An Earth-Abundant Water Oxidation Electrocatalyst with Superior Activity and Durability at Near Neutral pH.

There is an urgent demand to develop earth-abundant electrocatalysts for efficient and durable water oxidation under mild conditions. A nickel-substituted cobalt-borate nanowire array is developed on carbon cloth (Ni-Co-Bi/CC) via oxidative polarization of NiCo S nanoarray in potassium borate (K-Bi). As a bimetallic electrocatalyst for water oxidation, such Ni-Co-Bi/CC is superior in catalytic activity and durability in 0.

Core-Shell NiFe-LDH@NiFe-B Nanoarray: In Situ Electrochemical Surface Derivation Preparation toward Efficient Water Oxidation Electrocatalysis in near-Neutral Media.

The corrosion issue with acidic and alkaline water electrolyzers can be avoided by developing water oxidation catalysts performing efficiently under benign conditions. In this Letter, we report that a NiFe-borate layer can be generated on a NiFe-layered double hydroxide nanosheet array hydrothermally grown on carbon cloth via an in situ electrochemical surface derivation process in potassium borate (K-B) solution. The resulting 3D NiFe-LDH@NiFe-B nanoarray (NiFe-LDH@NiFe-B/CC) demonstrates high activity for water oxidation, demanding overpotentials of 444 and 363 mV to achieve 10 mA cm in 0.

NiCoP Nanoarray: A Superior Pseudocapacitor Electrode with High Areal Capacitance.

High-performance supercapacitors require the design and development of electrode materials with high conductivity and a large electrolyte-accessible surface area. Here, the use of a conductive NiCoP nanoarray on nickel foam (NiCoP/NF) as a superior pseudocapacitor electrode is demonstrated. This 3D electrode exhibits high areal capacitances of 9.

High-Efficiency and Durable Water Oxidation under Mild pH Conditions: An Iron Phosphate-Borate Nanosheet Array as a Non-Noble-Metal Catalyst Electrode.

It is highly desired but still remains a key challenge to develop iron-based large-surface-area arrays as heterogeneous water oxidation catalysts that perform efficiently and durably under mild pH conditions for solar-to-hydrogen conversion. In this work, we report the in situ derivation of an iron phosphate-borate nanosheet array on carbon cloth (Fe-Pi-Bi/CC) from an iron phosphide nanosheet array via oxidative polarization in a potassium borate (KBi) solution. As a 3D catalyst electrode for water oxidation at mild pH, such a Fe-Pi-Bi/CC shows high activity and strong long-term electrochemical durability, and it only demands an overpotential of 434 mV to drive a geometrical catalytic current density of 10 mA cm with maintenance of its activity for at least 20 h in 0.

One-pot synthesis of γ-MnS/reduced graphene oxide with enhanced performance for aqueous asymmetric supercapacitors.

In this work, γ-MnS/reduced graphene oxide composites (γ-MnS/rGO) were prepared using a facile one-pot hydrothermal method. As an electrode material for supercapacitors, the γ-MnS/rGO-60 composite obtained under dosages of graphene oxide  was 60 mg and exhibited an enhanced specific capacitance of 547.6 F g at a current density of 1 A g, and outstanding rate capability (65% capacitance retention at 20 A g), with superior cycling stability and electrochemical reversibility.

Construction of a Hierarchical NiCo2S4@PPy Core-Shell Heterostructure Nanotube Array on Ni Foam for a High-Performance Asymmetric Supercapacitor.

In this paper, a hierarchical NiCo2S4@polypyrrole core-shell heterostructure nanotube array on Ni foam (NiCo2S4@PPy/NF) was successfully developed as a bind-free electrode for supercapacitors. NiCo2S4@PPy-50/NF obtained under 50 s PPy electrodeposition shows a low charge-transfer resistance (0.31 Ω) and a high area specific capacitance of 9.

Biomimetic Mineralization of Tumor Targeted Ferromagnetic Iron Oxide Nanoparticles Used for Media of Magnetic Hyperthermia.

Background: The magnetic hyperthermia has been recognized as a useful therapeutic modality for malignant tumors, and IONPs have received a great deal of attentions for potential biomedical applications. The aims of this paper are to design a biomimetic mineralization procedure to synthesize the ferromagnetic and tumor targeting Fe3O4 nanoparticles, to conjugate bioactive molecule on particles, to analyze properties of product.

Methods: IONPs were synthesized with the WSG-PF127 as the mineralization templates, which were mixed by conjugating the peptide WSG on the surface of PF127.

Biopanning and characterization of peptides with Fe3O4 nanoparticles-binding capability via phage display random peptide library technique.

Functionalization of inorganic nanoparticles (NPs) play an important role in biomedical applications. A proper functionalization of NPs can improve biocompatibility, avoid a loss of bioactivity, and further endow NPs with unique performances. Modification with vairous specific binding biomolecules from random biological libraries has been explored.

Tumor-targeted paclitaxel-loaded folate conjugated poly(ethylene glycol)-poly(L-lactide) microparticles produced by supercritical fluid technology.

The new biodegradable diblock copolymers poly(ethylene glycol)-poly(L-lactide) (PEG-PLLA) were synthesized and were chemically conjugated with folate (FA) in the PEG terminal ends to form FA-PEG-PLLA. Then the hydrophobic drug paclitaxel (PTX) loaded microparticles (PTX/FA-PEG-PLLA) were produced via solution enhanced dispersion by supercritical fluids (SEDS). These microparticles exhibited sphere-like shape by scanning electron microscopy observation and showed narrow hydrodynamic size distributions by dynamic light scattering measurement.

Glucose oxidase adsorption performance of carbonaceous mesocellular foams prepared with different carbon sources.

Several carbonaceous mesocellular foams (C-MCFs) were prepared with MCF-silica as template using the carbon precursors of sucrose, furfuryl alcohol and lab-made phenolic resin, and the corresponding C-MCFs were named as C-MCF-Suc, C-MCF-FA and C-MCF-PR, respectively. The results of SEM, transmission electron microscopy, N2 adsorption-desorption and energy-dispersive X-ray measurements indicated that the C-MCFs prepared from different carbon source appeared morphologically with different degree of order and different pore distribution. The C-MCF-FA exhibited the highest ordered structure and the smallest pore distribution among the foams.

Effects of combinations of BMP-2 with FGF-2 and/or VEGF on HUVECs angiogenesis in vitro and CAM angiogenesis in vivo.

Angiogenesis, a complex biologic process, is regulated by a large number of angiogenic factors, including vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Whether Bone morphogenetic proteins-2 (BMP-2), the osteoinductive factor, could significantly reinforce the effect of VEGF and FGF-2 on angiogenesis has not been studied in detail. To study the positive effects of multiple growth factors on angiogenesis, HUVECs were treated with BMP-2, VEGF, or FGF-2 singly and in binary and ternary combinations.