Gram-Scale Synthesis of High-Loading Single-Atomic-Site Fe Catalysts for Effective Epoxidation of Styrene.

Single-atomic-site (SAS) catalysts, a new frontier of catalysts, always show extremely high atom efficiency and unexpected catalytic properties. Herein, a pyrolyzing coordinated polymer (PCP) strategy is developed, which is facile and widely applicable in the synthesis of a series of SAS catalysts including SAS-Fe, SAS-Ni, SAS-Cu, SAS-Zn, SAS-Ru, SAS-Rh, SAS-Pd, SAS-Pt, and SAS-Ir. The as-obtained SAS catalysts can be easily synthesized at gram scale and the metal loading of SAS-Fe catalysts achieves a record value of 30 wt%, which meets the requirement of practical applications.

Au@Pt Nanotubes within CoZn-Based Metal-Organic Framework for Highly Efficient Semi-hydrogenation of Acetylene.

Designing nanocatalysts with synergetic functional component is a desirable strategy to achieve both high activity and selectivity for industrially important hydrogenation reaction. Herein, we fabricated a core-shell hollow Au@Pt NTs@ZIFs (ZIF, zeolitic imidazolate framework; NT, nanotube) nanocomposite as highly efficient catalysts for semi-hydrogenation of acetylene. Hollow Au@Pt NTs were synthesized by epitaxial growth of Pt shell on Au nanorods followed with oxidative etching of Au@Pt nanorod.

Carbon Dots as a Protective Agent Alleviating Abiotic Stress on Rice ( L.) through Promoting Nutrition Assimilation and the Defense System.

Abiotic stress severely threatens agriculture. Herein, we studied the effect of heteroatom-free carbon dots (CDs) on the alleviation of abiotic stresses in rice for the first time. During in vitro coincubation, suspended rice cells were exposed to 2,4-dichlorophenoxyacetate sodium (2,4-D-Na, 30 μg mL), 2,4-dichlorophenoxyacetic acid (2,4-D, 5 μg mL), NaCl (0.

Mutated SASH1 promotes Mitf expression in a heterozygous mutated SASH1 knock‑in mouse model.

The SAM and SH3 domain‑containing 1 (SASH1) genes have been identified as the causal genes of dyschromatosis universalis hereditaria (DUH); these genes cause the pathological phenotypes of DUH, and SASH1 variants have been shown to regulate the abnormal pigmentation phenotype in human skin in various genodermatoses. However, investigations into the mutated SASH1 gene have been limited to in vitro studies. In the present study, to recapitulate the molecular pathological phenotypes of individuals with DUH induced by SASH1 mutations, a heterozygous BALB/c mouse model, in which the human SASH1 c.

Single atomic site catalysts: synthesis, characterization, and applications.

Single atomic site catalysts (SASCs) have attracted great attention in heterogenous catalysis due to their maximized atomic utilization and unique electronic structure. This feature article summarizes the recent contributions of the authors in the synthesis, characterization, and applications of SASCs. Firstly, we disclose the tricks of our recent progress in the synthesis of SASCs, including impregnation of metal precursors on defect-rich supports, pyrolysis of polymer-encapsulated metals and isolation of contiguous atoms by alloying.

Engineering unsymmetrically coordinated Cu-SN single atom sites with enhanced oxygen reduction activity.

Atomic interface regulation is thought to be an efficient method to adjust the performance of single atom catalysts. Herein, a practical strategy was reported to rationally design single copper atoms coordinated with both sulfur and nitrogen atoms in metal-organic framework derived hierarchically porous carbon (S-Cu-ISA/SNC). The atomic interface configuration of the copper site in S-Cu-ISA/SNC is detected to be an unsymmetrically arranged Cu-SN moiety.

Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host-guest strategy.

Single-atom catalysts not only maximize metal atom efficiency, they also display properties that are considerably different to their more conventional nanoparticle equivalents, making them a promising family of materials to investigate. Herein we developed a general host-guest strategy to fabricate various metal single-atom catalysts on nitrogen-doped carbon (M/CN, M = Pt, Ir, Pd, Ru, Mo, Ga, Cu, Ni, Mn). The iridium variant Ir/CN electrocatalyses the formic acid oxidation reaction with a mass activity of 12.

Engineering Isolated Mn-NC Atomic Interface Sites for Efficient Bifunctional Oxygen Reduction and Evolution Reaction.

Oxygen-involved electrochemical reactions are crucial for plenty of energy conversion techniques. Herein, we rationally designed a carbon-based Mn-NC bifunctional electrocatalyst. It exhibits a half-wave potential of 0.

Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis.

In this study, we explored expression and functions of circular RNA LPAR3 (circLPAR3) in esophageal squamous cell carcinoma (ESCC). The differential expression of circular RNAs (circRNAs) in 10 ESCC and corresponding paracarcinoma tissues was analyzed through circRNA microarray, then the candidate circRNAs were detected and verified through quantitative RT-PCR, and a novel circRNA was screened, which was circLPAR3. Circular RNA LPAR3 showed apparently high expression in ESCC tissues and cells, which was closely correlated with the clinical stage and lymph node metastasis of ESCC patients.

Selection of reference genes for RT-qPCR normalization in blueberry (Vaccinium corymbosum × angustifolium) under various abiotic stresses.

As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference genes greatly limits the functional study of blueberry genes. Therefore, in this study, we selected 14 candidate reference genes from a blueberry transcriptome database and used three algorithms (geNorm, NormFinder and BestKeeper) to evaluate the expression stability of these genes in various organs at different fruit developmental stages under five abiotic stress conditions.

Engineering of Electronic States on Co O Ultrathin Nanosheets by Cation Substitution and Anion Vacancies for Oxygen Evolution Reaction.

Due to the earth abundance and tunable electronic properties, etc., transition metal oxides (TMOs) show attractive attention in oxygen evolution reaction. O-vacancies (V ) play important roles in tailoring the local surface and electronic environment to lower the activation barriers.

Screening of Heavy Metal-Immobilizing Bacteria and Its Effect on Reducing Cd and Pb Concentrations in Water Spinach ( Forsk.).

Microbial immobilization is considered as a novel and environmentally friendly technology that uses microbes to reduce heavy metals accumulation in plants. To explore microbial resources which are useful in these applications, three water spinach rhizosphere soils polluted by different levels of heavy metals (heavy pollution (CQ), medium pollution (JZ), and relative clean (NF)) were collected. The community composition of heavy metal-immobilizing bacteria in rhizosphere soils and its effects on reducing the Cd and Pb concentrations in water spinach were evaluated.

Rhodobacter xinxiangensis sp. nov., isolated from pakchoi-cultivated soil contaminated with heavy metal and its potential to reduce Cd and Pb accumulation in pakchoi (Brassica campestris L.).

A Gram-stain-negative, aerobic, and motile strain, TJ48, was isolated from pakchoi-cultivated soil contaminated with Cd and Pb in Xinxiang (China). Cells of the strain were rod-shaped and colonies on LB agar were faint yellow. Strain TJ48 was positive for catalase and oxidase and the optimal condition for growth was 28 °C, with 1% (w/v) NaCl and at pH 7.

Isolated Ni Atoms Dispersed on Ru Nanosheets: High-Performance Electrocatalysts toward Hydrogen Oxidation Reaction.

Designing low-cost, high-efficiency, platinum-free electrocatalysts for the hydrogen oxidation reaction (HOR) in an alkaline electrolyte is of great importance for the development of anion exchange membrane fuel cells. Herein, we report a novel HOR catalyst, RuNi1, in which Ni is atomically dispersed on the Ru nanocrystals. To note, the as-prepared RuNi1 catalyst exhibits excellent catalytic activity and stability for HOR in alkaline media, which is superior to those of Ru-Ni bimetallic nanocrystals, pristine Ru, and commercial Pt/C catalysts.

In Situ Phosphatizing of Triphenylphosphine Encapsulated within Metal-Organic Frameworks to Design Atomic Co-PN Interfacial Structure for Promoting Catalytic Performance.

The engineering coordination environment offers great opportunity in performance tunability of isolated metal single-atom catalysts. For the most popular metal-N (MN) structure, the replacement of N atoms by some other atoms with relatively weak electronegativity has been regarded as a promising strategy for optimizing the coordination environment of an active metal center and promoting its catalytic performance, which is still a challenge. Herein, we proposed a new synthetic strategy of an in situ phosphatizing of triphenylphosphine encapsulated within metal-organic frameworks for designing atomic Co-PN interfacial structure, where a cobalt single atom is costabilized by one P atom and three N atoms (denoted as Co-SA/P-in situ).

Adsorption Site Regulation to Guide Atomic Design of Ni-Ga Catalysts for Acetylene Semi-Hydrogenation.

Atomic regulation of metal catalysts has emerged as an intriguing yet challenging strategy to boost product selectivity. Here, we report a density functional theory-guided atomic design strategy for the fabrication of a NiGa intermetallic catalyst with completely isolated Ni sites to optimize acetylene semi-hydrogenation processes. Such Ni sites show not only preferential acetylene π-adsorption, but also enhanced ethylene desorption.

Evaluate severe acute respiratory syndrome coronavirus 2 infectivity by pseudoviral particles.

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans in late 2019, it has rapidly spread worldwide. To identify the biological characteristics of SARS-CoV-2 in a normal laboratory environment (biosafety level 2 [BSL-2]), a lentiviral-based nucleocapsid was used to carry the spike protein of SARS-CoV-2 onto the surface of pseudoviral particles as a surrogate model to evaluate the infective characterization of SARS-CoV-2. This study indicated that SARS-CoV-2 has extensive tissue tropism for humans and may infect monkeys and tree shrews but not rodents.

Multifunctional molybdenum disulfide-copper nanocomposite that enhances the antibacterial activity, promotes rice growth and induces rice resistance.

Molybdenum disulfide sheets loaded with copper nanoparticles (MoS-CuNPs) was prepared and its antibacterial activity against phytopathogen Xanthomonas oryzae pv. oryzae (Xoo) was investigated in vitro and in vivo for the first time. In a 2 h co-incubation, MoS-CuNPs exhibited 19.

Chemical Synthesis of Single Atomic Site Catalysts.

Manipulating metal atoms in a controllable way for the synthesis of materials with the desired structure and properties is the holy grail of chemical synthesis. The recent emergence of single atomic site catalysts (SASC) demonstrates that we are moving toward this goal. Owing to the maximum efficiency of atom-utilization and unique structures and properties, SASC have attracted extensive research attention and interest.

Rare-Earth Single Erbium Atoms for Enhanced Photocatalytic CO Reduction.

The solar-driven photocatalytic reduction of CO (CO RR) into chemical fuels is a promising route to enrich energy supplies and mitigate CO emissions. However, low catalytic efficiency and poor selectivity, especially in a pure-water system, hinder the development of photocatalytic CO RR owing to the lack of effective catalysts. Herein, we report a novel atom-confinement and coordination (ACC) strategy to achieve the synthesis of rare-earth single erbium (Er) atoms supported on carbon nitride nanotubes (Er /CN-NT) with a tunable dispersion density of single atoms.

Facet engineering in metal organic frameworks to improve their electrochemical activity for water oxidation.

The facet effect has been well demonstrated for nanocrystal catalysis, however it is rarely revealed in metal organic frameworks (MOFs). Herein, we present a facile way to construct 2D zeolitic imidazolate framework-67 (ZIF-67) with dominant exposure of the (002) facets. We discovered that the ZIF-67 (002) facet exhibited the highest catalytic activity for oxygen evolution reaction (OER) among the (002), (011), and (111) facets.

Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats.

Objectives: Although many studies have examined changes in gut microbiota composition in gastric carcinogenesis to clarify the mechanism of action of anticancer drugs, it is unclear whether animal models of gastric carcinogenesis adequately reflect the disease in humans.

Methods: To address this issue, the present study investigated changes in the gut microbiome profile of a rat model of gastric carcinogenesis established using a combination of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), sodium salicylate, irregular fasting, and ranitidine. The rats were divided into control (Normal), chronic non-atrophic gastritis (CNAG), chronic atrophic gastritis (CAG), precancerous lesion of gastric cancer (PLGC), and gastric cancer (GC) groups according to histopathological features.

Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release.

The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG). It remains unknown how the SuM and DG coordinate their activities at the circuit level to regulate spatial memory. Additionally, SuM co-releases GABA and glutamate to the DG, but the relative role of GABA versus glutamate in regulating spatial memory remains unknown.