The PI3K-Akt pathway is a multifaceted regulator of the macrophage response to diverse group B isolates.

Group B (GBS), also known as , is a common member of the microbial flora in healthy individuals. However, problems may arise when GBS-colonized mothers become pregnant. GBS may be transferred from a colonized mother to her newborn or developing fetus, which may result in complications such as miscarriage, pre-term birth, meningitis, pneumonia, or sepsis.