Publications by authors named "Yadiel Vazquez-Mena"
Article Synopsis
- Researchers developed a strategy to create long chains of carbohydrates like cellulose, chitin, and xylan, which were previously hard to synthesize due to lack of standards.
- They used enzyme-triggered assembly (ETA) to manipulate these carbohydrate chains into various shapes, such as platelets and helical structures, elucidating their molecular behavior through advanced imaging techniques.
- The study highlights that ETA, when combined with custom sequence design, offers a promising method for creating diverse and structured carbohydrate materials, enhancing our understanding of carbohydrate aggregation.
The stabilization of helical structures by peptide stapling approaches is now a mature technology capable to provide a variety of biomedical applications. Recently, it was shown that multicomponent macrocyclization is not only an effective way to introduce conformational constraints but it also allows to incorporate additional functionalities to the staple moiety in a one-pot process. This work investigates the scope of the double Ugi multicomponent stapling approach in its capacity to produce helical peptides from unstructured sequences.
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