Publications by authors named "Yaddanapudi Narayana"

Objectives: Coagulation changes associated with COVID-19 suggest the presence of a hypercoagulable state with pulmonary microthrombosis and thromboembolic complications. We assessed the dynamic association of COVID-19-related coagulation abnormalities with respiratory failure and mortality.

Design: Single-centre, prospective cohort study with descriptive analysis and logistic regression.

View Article and Find Full Text PDF

Background: Although hydroxychloroquine (HCQ) lacks benefit in patients with moderate-to-severe COVID-19, its role in asymptomatic and mildly symptomatic disease needs better elucidation.

Methods: This multi-centre cohort study included asymptomatic and mildly symptomatic, RT-PCR confirmed COVID-19 cases between 30 March and 20 May, 2020. Patients were categorized into two groups (HCQ-treated and untreated) based on exposure to HCQ.

View Article and Find Full Text PDF

Objectives: Healthcare personnel (HCP) are at an increased risk of acquiring COVID-19 infection especially in resource-restricted healthcare settings, and return to homes unfit for self-isolation, making them apprehensive about COVID-19 duty and transmission risk to their families. We aimed at implementing a novel multidimensional HCP-centric evidence-based, dynamic policy with the objectives to reduce risk of HCP infection, ensure welfare and safety of the HCP and to improve willingness to accept and return to duty.

Setting: Our tertiary care university hospital, with 12 600 HCP, was divided into high-risk, medium-risk and low-risk zones.

View Article and Find Full Text PDF

Background: Vitamin D has an immunomodulatory role but the effect of therapeutic vitamin D supplementation in SARS-CoV-2 infection is not known.

Aim: Effect of high dose, oral cholecalciferol supplementation on SARS-CoV-2 viral clearance.

Design: Randomised, placebo-controlled.

View Article and Find Full Text PDF
Article Synopsis
  • The study monitored changes in Candida species causing candidaemia over 20 years and found an increase in cases, with Candida tropicalis being the most common species.
  • The research involved analyzing blood samples and utilized advanced methods like MALDI-TOF for species identification and antifungal susceptibility testing.
  • Results highlighted a significant rise in amphotericin B resistance and emphasized the need for routine antifungal susceptibility testing due to the emergence of multidrug-resistant species like Candida auris.
View Article and Find Full Text PDF