Publications by authors named "Yada Zhang"
Article Synopsis
- Severe asthma has distinct molecular biomarkers that can improve understanding and diagnostics, and this study aims to identify those biomarkers and their biological processes.
- The research employed various analytical methods, such as WGCNA and GSEA, to pinpoint significant genes and pathways linked to severe asthma from different datasets and confirmed the findings with a LASSO regression model.
- Key results highlighted 12 common genes, including TFCP2L1 and CCL5, with significant changes in expression related to severe asthma, indicating that mitochondrial dysfunction and oxidative phosphorylation are critical in its pathology.
Objectives: We previously revealed that scorpio and centipede (SC) improve the inflammatory response in asthma, whereas it is unclear whether ferroptosis is involved in this process.
Materials And Methods: The asthmatic mouse model was established and lung tissues were collected for histopathological examination. The levels of tumor necrosis factor-α (TNF-α), interleukin- (IL-)1β, Fe, malondialdehyde (MDA), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1(FTH1), and reactive oxygen species (ROS) were assessed in asthmatic mice and mouse airway epithelial cells.
Background: Clinical decision-making is enhanced by the development of a mathematical model for prognosis prediction. Screening criteria associated with viral shedding time and developing a prediction model facilitate clinical decision-making and are, thus, of great medical value.
Methods: This study comprised 631 patients who were hospitalized with mild COVID-19 from a single center and 30 independent variables included.
Asthma is one of the most common chronic inflammatory diseases. Although the scorpion and centipede (SC) significantly ameliorates asthma and changes exosomal miRNAs, the molecular mechanism is still obscure. Here, we show that SC improves inflammation in asthmatic mice and increases M2 macrophage-derived exosomes (M2Φ-Exos) by promoting M2 macrophage polarization.
View Article and Find Full Text PDFObjective: To improve the level of clinical diagnosis and differential diagnosis of benign and malignant prostate lesions.
Methods: One hundred and nine cases of prostate cancer and prostate hyperplasia were evaluated by the expression of high molecular weight cytokeratin (CK34BE12), prostate specific antigen (PSA) and protein P53 gene using the immunohistochemical technique.
Results: The basal-cells in all of the benign lesions were stained with the CK34BE12 and PSA, while it had not immunoreactivity with P53.
[Diagnosis and treatment of incidental prostate cancer following TUPVP (a report of 15 cases)].
Zhonghua Nan Ke Xue
November 2004
Objective: To investigate the diagnosis and treatment of incidental prostate cancer (IPC) following transurethral plasma kinetic vaporization prostatectomy (TUPVP).
Methods: Pathological examinations were conducted on 134 benign prostate hyperplasia specimens by means of series microtomy after TUPVP.
Results: Fifteen cases of IPC were detected from the total number of TUPVP specimens, with a pick-up rate of 11.