Publications by authors named "Yacine Khelif"
Article Synopsis
- Alteration of the extracellular matrix (ECM) is a key factor in brain damage after an ischemic stroke, and heparan sulfate mimetics (HSm) can help restore it and promote tissue repair.
- In a study on rats, researchers tested HSm4131, a synthetic polysaccharide, to see if it could protect brain tissue and enhance recovery after inducing stroke-like conditions.
- The results showed that HSm4131 improved brain repair processes, reduced functional deficits, and provided long-lasting neuroprotection, indicating its potential as a treatment for stroke recovery.
Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404).
Sylvie Chevret Suzanne Verlhac Elisabeth Ducros-Miralles Jean-Hugues Dalle Regis Peffault de Latour Yacine Khelif
Contemp Clin Trials
November 2017
Article Synopsis
- Kids with sickle cell anemia have a higher chance (11%) of having a stroke before they're 18, but regular blood transfusions can help reduce this risk.
- The DREPAGREFFE study is testing if getting a stem cell transplant from a sibling is better than blood transfusions for these kids, while looking at their health and quality of life.
- The goal is to see if the stem cell transplant leads to better results (like lower blood flow speeds in the brain) compared to just getting transfusions.
Objective: Clinical studies demonstrated a potential link between atherosclerosis and periodontitis. Porphyromonas gingivalis (Pg), one of the main periodontal pathogen, has been associated to atheromatous plaque worsening. However, synergism between infection and other endothelial stressors such as oxidized-LDL or TNF-α especially on endothelial cell (EC) death has not been investigated.
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