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Publications by authors named "Yachuang Hu"

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Whole-brain spatial organization of hippocampal single-neuron projectomes.
Shou Qiu Yachuang Hu Yiming Huang Taosha Gao Xiaofei Wang Yuzhe Huang Jiawen Huang Hui Gong Chun Xu

Science

February 2024

Article Synopsis
  • Mapping single-neuron projections in the hippocampus (HIP) is crucial to grasping how the brain's connectivity and functions work.
  • Researchers reconstructed over 10,000 single-neuron projectomes and identified 43 distinct subtypes based on their projection patterns.
  • The study revealed that projection characteristics vary based on neuron location in the HIP and highlighted wiring diagrams for neurons connecting within the HIP and to other brain regions, informing us about their functional roles.
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Single-neuron projectome of mouse prefrontal cortex.
Le Gao Sang Liu Lingfeng Gou Yachuang Hu Yanhe Liu Chun Xu Hui Gong

Nat Neurosci

April 2022

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain activity. However, the whole-brain organization of PFC axon projections remains poorly understood. Using single-neuron reconstruction of 6,357 mouse PFC projection neurons, we identified 64 projectome-defined subtypes.

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Synopsis of recent research by authors named "Yachuang Hu"

  • - Yachuang Hu's recent research focuses on the spatial organization of brain connectivity, specifically through the mapping of single-neuron projectomes in the hippocampus and prefrontal cortex of mice.
  • - In the study of the hippocampus, Hu and his team reconstructed 10,100 single-neuron projectomes and identified 43 distinct projectome subtypes, revealing how projection patterns vary depending on the neuron’s location within the brain.
  • - The exploration of the prefrontal cortex involved analyzing 6,357 projection neurons, leading to the classification of 64 projectome-defined subtypes, which enhances the understanding of cognitive functions and brain activity regulation.

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