Clinical results of ab interno trabeculotomy using the trabectome for open-angle glaucoma: the Mayo Clinic series in Rochester, Minnesota.

Purpose: To determine outcomes of ab interno trabeculotomy for treatment of open-angle glaucoma (OAG).

Design: Retrospective interventional single-surgeon, single-center case series.

Methods: Data were collected from 246 patients undergoing ab interno trabeculotomy between September 1, 2006, and December 1, 2010, with 3 months' follow-up or longer.

Delayed-onset symptomatic hyphema after ab interno trabeculotomy surgery.

Purpose: To describe patients who have experienced delayed-onset hyphema after ab interno trabeculotomy surgery with the Trabectome (Neomedix Corp) for open-angle glaucoma.

Design: Retrospective case series.

Methods: study population: Patients at Mayo Clinic, Rochester, Minnesota, who underwent Trabectome surgery between September 1, 2006, and December 31, 2010, and who had symptomatic hyphema at least 2 months after surgery.

Decreased corneal sensitivity and abnormal corneal nerves in Fuchs endothelial dystrophy.

Purpose: To determine corneal sensitivity and evaluate corneal nerves before and after keratoplasty for Fuchs endothelial dystrophy.

Methods: Central corneal sensitivity, measured by using a Cochet-Bonnet esthesiometer in 69 eyes before and after different keratoplasty procedures for Fuchs dystrophy, was compared with that of 35 age-matched normal corneas. Corneal nerves were qualitatively examined by confocal microscopy in 42 eyes before and after Descemet stripping endothelial keratoplasty (DSEK).

Posterior vitreous detachment and retinal tear after repetitive transcranial magnetic stimulation.

This case report describes a 60-year-old woman who experienced a posterior vitreous detachment (PVD) and retinal tear after her 11th session of 1 Hz repetitive transcranial magnetic stimulation (rTMS) for the treatment of major depression. Although we cannot conclude that rTMS caused her PVD and retinal tear, the temporal association is strong, and we hypothesize a possible pathophysiology of the event. As part of the routine clinical monitoring of rTMS side effects, we encourage attention toward ophthalmologic symptoms, especially in older patients.

Potentially deadly carcinogenic chromium redox cycle involving peroxochromium(IV) and glutathione.

Peroxochromium(IV) complexes are putative DNA-damaging and mutagenic agents in chromium(VI)-mediated carcinogenesis. The reaction between aquaethylenediaminebis(peroxo)chromium(IV) and glutathione at neutral pH exhibits a cyclic redox process displaying a persistent recycling of Cr(IV) and Cr(VI) with the intervention of chromium(V) intermediates. The coordination by a glutathione molecule triggers an autooxidation of the Cr(IV)-peroxo complex to Cr(VI) via an internal electron-transfer process followed by reduction to Cr(IV) via metastable chromium(V) intermediates.

Unilateral megalopapilla and contralateral optic nerve hypoplasia: a case report and review of the literature.

We report the incidental finding of megalopapilla in the contralateral eye of a 10-year-old black child with optic nerve hypoplasia. Megalopapilla is a rare entity characterized by an enlarged optic disk without other morphologic abnormalities except for an enlarged cup/disk ratio. To the best of our knowledge, the concurrence of megalopapilla and optic nerve hypoplasia in the same individual has not been reported previously.

CNGA3 mutations in two United Arab Emirates families with achromatopsia.

Purpose: ACHROMATOPSIA RESULTS FROM MUTATIONS IN ONE OF THREE GENES: cyclic nucleotide-gated channel, alpha-3 (CNGA3); cyclic nucleotide-gated channel, beta-3 (CNGB3); and guanine nucleotide-binding protein, alpha-transducing activity polypeptide 2 (GNAT2). We report the responsible mutations in two United Arab Emirates families who have this autosomal recessive disease.

Methods: Clinical examinations were performed in seven patients from three nuclear families.