Publications by authors named "Yabo Hu"
Background: Historically, malaria due to Plasmodium vivax has been epidemic in Henan Province, China, with Anopheles sinensis as the main vector. The most effective measures to prevent malaria transmission are based on vector control through the use of insecticides. However, insecticides exert a strong selective pressure on mosquito populations for insecticide resistance.
View Article and Find Full Text PDFA side-reactor column (SRC) configuration, comprising a vacuum column coupled with atmospheric side reactors, is proposed to overcome the thermodynamic restriction in the esterification of cyclohexene with acetic acid to produce cyclohexyl acetate. Meantime, this configuration can avoid the utilization of the high-pressure steam and provide enough zone for catalyst loading. In order to obtain the minimum total annual cost (TAC), the process is optimized by a mixed-integer nonlinear programming optimization method based on the improved bat algorithm.
View Article and Find Full Text PDFArticle Synopsis
- Plasmodium falciparum malaria poses a significant health risk globally, leading to research on the PfCSP protein as a potential vaccine target despite its genetic variability affecting vaccine effectiveness.
- The study analyzed blood samples from 287 Chinese migrant workers returning from Africa, identifying key genetic variations in the PfCSP gene, including notable mutations and a high level of nucleotide diversity.
- Findings indicated that while certain regions of the PfCSP gene were conserved, others showed signs of positive selection and moderate genetic differentiation between various African populations, providing insights for vaccine development.
One Health is a collaborative, multi-sectoral, trans-disciplinary approach with the goal of achieving optimal health outcomes by recognizing the interconnection between people, animals, plants, and the environment and determining how this relates to the control of infectious diseases such as malaria, schistosomiasis and so on. Malarias caused by Plasmodium that commonly infects female Anopheles mosquitoes, which feed on human blood and act as a disease vector. It has been a worldwide important public health problem from ancient times.
View Article and Find Full Text PDFThe "1-3-7" approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization (WHO) as an international guideline for malaria surveillance and response in 2018. The "1-3-7" approach was well implemented in Henan Province from 2012-2018. Over this study period, a total of 1,294 malaria cases were detected and reported, and all cases were diagnosed and reported within 1 day with 99.
View Article and Find Full Text PDFAspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line.
Open Med (Wars)
September 2019
Article Synopsis
- Recent studies highlight aspirin's antitumor properties, particularly its role in inhibiting angiogenesis, but the exact mechanisms are still unclear.
- This research shows that aspirin can down-regulate glucose transporter 1 (GLUT1), reducing glucose uptake in vascular endothelial cells (ECs) and affecting their glucose metabolism.
- Additionally, aspirin impacts the synthesis of ATP and lactate in these cells and alters the phosphorylation of NF-κB p65, suggesting GLUT1 as a potential target for aspirin’s effects in vascular ECs.
Purpose: This study aims to understand the effects and long-term survival of 1st generation epithelial growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)or platinum-based chemotherapy as first-line therapy in advanced lung adenocarcinoma patients with uncommon EGFR mutations.
Patients And Methods: Specimens from 4276 advanced (IIIB/IV) patients were diagnosed with lung adenocarcinoma and underwent EGFR gene detection at the Affiliated Cancer Hospital of Zhengzhou University. The clinic characteristics, survival outcomes data, treatment outcomes and data of subsequent therapies after first-line treatment were collected of patients with uncommon EGFR mutations.