Psychometric validation and refinement of the Chinese Interoceptive Accuracy Scale (IAS) in general population and patients with chronic pain.

Objective: Interoception plays an important role in psychological functioning and mental and physical health. Recent studies have highlighted the need to distinguish between different aspects of interoception in self-report measures, including subjective interoceptive accuracy and attention. However, there is currently no questionnaire available in Chinese to measure either of these aspects, especially in patients with chronic pain conditions.

Ferrous ascorbate as a potential biomarker for diabetic retinopathy: a vitreous humour metabolomics study.

Background: This study aimed to explore differences in vitreous humour metabolites and metabolic pathways between patients with and without diabetic retinopathy (DR) and identify potential metabolite biomarkers.

Methods: Clinical data and vitreous fluid samples were collected from 125 patients (40 without diabetes, 85 with DR). The metabolite profiles of the vitreous fluid samples were analysed using ultra-high performance liquid chromatography, Q-Exactive mass spectrometry, and multivariate statistical analysis.

Dyadic effects of financial toxicity and social support on the fear of cancer recurrence in breast cancer patients and caregivers: an actor-partner interdependence mediation model.

Purpose: In this study, the actor-partner interdependence mediation model (APIMeM) was applied to breast cancer patients and their caregivers to assess the factors that affect the fear of cancer recurrence. In particular, the purpose of this study was to evaluate the mediating effect of social support on financial toxicity and the fear of cancer recurrence, providing an effective basis for developing plans to reduce the level of fear of cancer recurrence.

Methods: This study employed a cross-sectional design, and 405 dyads of breast cancer patients and their caregivers were enrolled.

MediDRNet: Tackling category imbalance in diabetic retinopathy classification with dual-branch learning and prototypical contrastive learning.

Background And Objective: The classification of diabetic retinopathy (DR) aims to utilize the implicit information in images for early diagnosis, to prevent and mitigate the further worsening of the condition. However, existing methods are often limited by the need to operate within large, annotated datasets to show significant advantages. Additionally, the number of samples for different categories within the dataset needs to be evenly distributed, because the characteristic of sample imbalance distribution can lead to an excessive focus on high-frequency disease categories, while neglecting the less common but equally important disease categories.

Applications of nanomaterials in anti-VEGF treatment for ophthalmic diseases.

Angiogenesis has been determined to be essential in the occurrence and metastasis of diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vein occlusion (RVO), choroidal neovascularization (CNV), retinopathy of prematurity (ROP), tumor, etc. However, the clinical use of anti-vascular endothelial growth factors (VEGF) drugs is currently limited due to its high cost, potential side effects, and need for repeated injections. In recent years, nanotechnology has shown promising results in inhibiting neovascularization and reducing reactive oxygen species (ROS) or inflammatory factors.

Soreness Reminds Me of Grief: Patients With Chronic Pain Show Less Differentiated Representations of Emotional Feelings and Bodily States.

People experience similarities between emotional feelings and bodily states on a daily basis, but both the magnitude and pervasiveness of this experiential similarity vary across individuals. Inspired by previous findings that chronic pain (CP) is characterized by strengthened pain-affect coupling and reduced interoceptive accuracy, we conducted 2 cross-sectional studies to examine whether patients with CP would exhibit less differentiated perception and mental representation of emotional feelings and bodily states. In study 1 (N = 500), patients with CP and healthy controls (HCs) completed a self-report questionnaire that asked explicitly about the perceived similarity between 5 basic emotion categories and a series of bodily states.

A new ultra-wide-field fundus dataset to diabetic retinopathy grading using hybrid preprocessing methods.

Diabetic retinopathy(DR) is a common early diabetic complication and one of the main causes of blindness. In clinical diagnosis and treatment, regular screening with fundus imaging is an effective way to prevent the development of DR. However, the regular fundus images used in most DR screening work have a small imaging range, narrow field of vision, and can not contain more complete lesion information, which leads to less ideal automatic DR grading results.

The Relationship between Perfectionism and Social Anxiety: A Moderated Mediation Model.

Social anxiety is one of the mental health problems associated with perfectionism. The present study investigated the possible mediation of perceived stress in the relationship between perfectionism and social anxiety, and whether this mediation depends on the level of trait mindfulness. A total of 425 college students (female: 82.

Identification of 5 microRNA biomarkers associated with the prognosis of uveal melanoma.

To uncover the role of microRNAs in the occurrence and development of uveal melanoma (UM), we used R language packages in this study to analyze the correlations between the expression of microRNA isoforms, their target genes, and the clinical data for UM patients retrieved from The Cancer Genome Atlas (TCGA). We used Weighted Correlation Network Analysis (WGCNA) to divide the expression profiles of different microRNAs into 10 modules, among which blue and yellow modules were associated with UM survival. Hsa-miR-513a-5p, miR-506-3p, miR-508-3p, miR-140-3p, and miR-103a-2-5p were further identified as the top 5 node microRNAs based on the risk scores in both modules using least absolute shrinkage and selection operator (LASSO) Cox regression analysis.

The mediating effects of coping styles on the relationship between trait mindfulness and romantic relationship satisfaction.

The purpose of the current study was to explore the influence of coping styles and trait mindfulness on the satisfaction of romantic relationships (RRS) among college students. Of the 305 participants, 258 (males: 115, 44.6%) had previously been in, or were presently in a romantic relationship.

The Trend of 2D Transistors toward Integrated Circuits: Scaling Down and New Mechanisms.

2D transition metal chalcogenide (TMDC) materials, such as MoS , have recently attracted considerable research interest in the context of their use in ultrascaled devices owing to their excellent electronic properties. Microprocessors and neural network circuits based on MoS have been developed at a large scale but still do not have an advantage over silicon in terms of their integrated density. In this study, the current structures, contact engineering, and doping methods for 2D TMDC materials for the scaling-down process and performance optimization are reviewed.

Vertical MoS transistors with sub-1-nm gate lengths.

Ultra-scaled transistors are of interest in the development of next-generation electronic devices. Although atomically thin molybdenum disulfide (MoS) transistors have been reported, the fabrication of devices with gate lengths below 1 nm has been challenging. Here we demonstrate side-wall MoS transistors with an atomically thin channel and a physical gate length of sub-1 nm using the edge of a graphene layer as the gate electrode.

A Bibliometric and Visualization Analysis of Mindfulness and Meditation Research from 1900 to 2021.

This study comprehensively summarizes research in the field of meditation, especially mindfulness meditation from 1900 to 2021, by analyzing the knowledge map through CiteSpace and VOSviewer software. Using "mindfulness *" or "meditation *" as the topic, articles included in the Science Citation Index Expanded and Social Sciences Citation Index were searched in the web of science core database, resulting in the selection of 19,752 articles. Over half a century ago, Deikman published the field's first article in the Journal of Nervous and Mental Disease in 1963, and publications have soared in subsequent decades.

Ultrafast non-volatile flash memory based on van der Waals heterostructures.

Flash memory has become a ubiquitous solid-state memory device widely used in portable digital devices, computers and enterprise applications. The development of the information age has demanded improvements in memory speed and retention performance. Here we demonstrate an ultrafast non-volatile flash memory based on MoS/hBN/multilayer graphene van der Waals heterostructures, which achieves an ultrafast writing/erasing speed of 20 ns through two-triangle-barrier modified Fowler-Nordheim tunnelling.

Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway.

Context: Xinmai 'an tablet has been used to improve myocardial blood supply. Recently, some compounds from its formula have shown that they can treat pulmonary arterial hypertension (PAH).

Objective: This study investigates the effects of Xinmai 'an extract (XMA) on PAH and further tests the co-therapeutic enhancement with sildenafil (SIL).

Numerical Analysis of a Continuous Vulcanization Line to Enhance CH Reduction in XLPE-Insulated Cables.

Herein, we apply a computational diffusion model based on Fick's law to study the manner in which a cable production line and its operating conditions can be enhanced to effectively reduce the CH4 concentration in cables insulated with cross-linked polyethylene (XLPE). Thus, we quantitatively analyze the effect of the conductor temperature, curing tube temperature distribution, transition zone length, and online relaxation on CH4 generation and transport during the production of 132 kV cables with an insulation thickness of 16.3 mm.

Numerical Study of CH Generation and Transport in XLPE-Insulated Cables in Continuous Vulcanization.

In this work, we apply a computational diffusion model based on Fick's laws to study the generation and transport of methane (CH 4 ) during the production of a cross-linked polyethylene (XLPE) insulated cable. The model takes into account the heating process in a curing tube where most of the cross-linking reaction occurs and the subsequent two-stage cooling process, with water and air as the cooling media. For the calculation of CH 4 generation, the model considers the effect of temperature on the cross-linking reaction selectivity.

Ambiguity Processing Bias Induced by Depressed Mood Is Associated with Diminished Pleasantness.

Depressed individuals are biased to perceive, interpret, and judge ambiguous cues in a negative/pessimistic manner. Depressed mood can induce and exacerbate these biases, but the underlying mechanisms are not fully understood. We theorize that depressed mood can bias ambiguity processing by altering one's subjective emotional feelings (e.

Controlling Factors of Degassing in Crosslinked Polyethylene Insulated Cables.

Here, we analyze the degassing process of a byproduct (methane) formed during the peroxide-induced crosslinking of polyethylene. A diffusion model based on Fick's law is used to obtain the controlling factors of degassing in a crosslinked polyethylene (XLPE) insulated power cable (132 kV with 18 mm of insulation). We quantitatively analyze different scenarios of the diffusion of methane through the XLPE insulation and two semiconductor layers under various in situ degassing conditions.

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway.

Background: Although the results of our and other studies show that baicalin can enhance glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice, the specific metabolic contribution of baicalin on hepatic insulin resistance and gluconeogenic activity is still unclear.

Purpose: The aim of this study is to investigate whether baicalin is involved in regulation of hepatic insulin resistance and gluconeogenic activity and its underlying mechanisms.

Study Design/methods: In the present study, high-fat diet-induced obese mice were given 50 mg/kg baicalin intraperitoneally (i.

Neuroprotective effects of overexpressed microRNA-200a on activation of glaucoma-related retinal glial cells and apoptosis of ganglion cells via downregulating FGF7-mediated MAPK signaling pathway.

Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness in the industrialized countries. The involvement of microRNAs (miRs) has been implicated in regulating the complex biological responses to changes in intraocular pressure. However, the therapeutic role of miR-200a on glaucoma has not been well studied yet.

Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study.

Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory.

Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression.

Background: A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human RB.