Static Torque Analysis of Micro Claw-Pole Stepper Motor Based on Field-Circuit Combination.

Because of the complexity of the structure and magnetic circuit of the micro claw-pole stepper motor, it is difficult to analyze this kind of motor quickly and accurately. Therefore, it takes a lot of time to accurately model and use the three-dimensional finite element analysis method to accurately analyze the motor. Regarding the three-dimensional finite element method, the equivalent magnetic circuit method analysis is fast, but the accuracy is not high.

Sandwich membranes based on PVDF-g-4VP and surface modified graphene oxide for Cu(II) adsorption.

UV photo-preactivation/thermally-induced grafting was employed for grafting 4-vinylpyridine (4-VP) on polyvinylidene fluoride (PVDF), and graphene oxide (GO) was modified with 4'-carboxy-2,2':6',2"-terpyridine (CTPy). Then sandwich PVDF-g-4VP/GO-CTPy/polytetrafluoroethylene (PTFE) membrane was fabricated for adsorption of Cu (II) as a model. The membrane formation, static adsorption thermodynamics, kinetics and dynamic adsorption/desorption were studied.

Synthesis and biological properties of polyamine modified flavonoids as hepatocellular carcinoma inhibitors.

A series of polyamine conjugates of flavonoids with a naphthalene motif were synthesized and evaluated for their anti-hepatocellular carcinoma properties using in vitro and in vivo assays. Compound 8a displayed favorable selectivity between hepatocellular carcinoma cells and normal hepatocyte cells, and the combination of 8a with aspirin resulted in additive inhibition of in vitro tumor cell growth and migration. The 8a-aspirin combination also inhibited H22 liver tumor growth and pulmonary metastasis and improved body weight index in animal models.

Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.

Three types of aromatic-polyamine conjugates (6a-6s) were designed, synthesized and evaluated as potential inhibitors for cholinesterases (ChEs). The results showed that anthraquinone-polyamine conjugates (AQPCs) exhibited the most potent acetylcholinesterase (AChE) inhibitory activity with IC50 values from 1.50 to 11.

[Design, synthesis and evaluation of bis-nicotine derivatives as inhibitors of cholinesterases and beta-amyloid aggregation].

A novel series of bis-nicotine derivatives (3a-3i) were designed, synthesized and evaluated as bivalent anti-Alzheimer's disease agents. The pharmacological results indicated that compounds 3e-3i inhibited both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in the micromolar range (IC50, 2.28-117.

Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.

A series of 4-dimethylamine flavonoid derivatives 5a-5r were designed, synthesized and evaluated as potential multi-functional anti-Alzheimer agents. The results showed that most of the synthesized compounds exhibited high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity at the micromolar range (IC50, 1.83-33.

[Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors].

A series of tacrine-methoxybenzene hybrids (5a-5i) were designed, synthesized and evaluated as inhibitors of cholinesterases (ChEs). All the compounds had better ChEs inhibitory activities than tacrine with IC50 values at the nanomolar range. Compound 5h exhibited the strongest inhibition on acetylcholinesterase (AChE) with an IC50 value of 6.