Publications by authors named "Yabei Fan"
Cytokines in cerebrospinal fluid as a prognostic predictor after treatment of nusinersen in SMA patients.
Clin Neurol Neurosurg
September 2024
Article Synopsis
- - This study investigates the link between neuroinflammation and spinal muscular atrophy (SMA), focusing on how it impacts the effectiveness of nusinersen, a treatment for the condition.
- - Researchers evaluated 15 SMA patients' motor functions and measured specific inflammatory biomarkers (MCP1, TNF-α, IL-10) in their cerebrospinal fluid before, during, and after 6 months of nusinersen treatment.
- - Results showed increased MCP1 levels and decreased TNF-α over time, with IL-10 levels negatively impacting motor function scores, indicating that neuroinflammation might affect both SMA severity and treatment outcomes.
Background: Contralaterally controlled functional electrical stimulation (CCFES) is an innovative method to improve upper extremity functions after stroke.
Objective: To compare the effects of CCFES versus neuromuscular electrical stimulation (NMES) on the upper extremity functions in patients with stroke.
Methods: Sixty patients with stroke were randomly assigned into CCFES group (n=30) or NMES group (n=30).