Publications by authors named "Yabe H"
Background: The effectiveness of rehabilitation aimed at improving the activities of daily living and physical functions may differ between hospitalized patients undergoing hemodialysis (HD) and not undergoing HD (non-HD). The aim of the present study was to compare the outcomes of rehabilitation between hospitalized HD and non-HD patients.
Methods: This was a retrospective cohort study of inpatients who underwent rehabilitation.
Introduction: Compared to platinum-based therapies, a combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) has demonstrated improved outcomes in advanced non-small cell lung cancer (NSCLC), albeit with higher rates of immune-related adverse events (irAEs). This multicenter retrospective study evaluated the efficacy and safety of nivolumab and ipilimumab with or without chemotherapy (NI and NICT) in real-world clinical settings.
Methods: We enrolled 215 treatment-naïve NSCLC patients who received NI or NICT between December 2020 and May 2023 at 14 institutions in Japan.
Objectives: Managing presenteeism among patients with chronic kidney disease (CKD) is important for balancing disease management and employment. This study aimed to investigate presenteeism, exercise self-efficacy (SE), and physical function indices in workers with CKD and to examine the factors that influence presenteeism in this patient group.
Methods: This cross-sectional study included 36 workers with stage 3-5 pre-dialysis CKD.
Objectives: The Russian-Ukrainian War of 2022 (RUW-2022) was accompanied by the subsequent risk of accidents at a nuclear power plant in Ukraine. This study investigated posttraumatic stress (PTS) symptoms related to media reports of an attack on a Ukrainian nuclear power plant during the RUW-2022 among victims of the Fukushima nuclear disaster and revealed their association with radiation risk perception (RRP) of the accident.
Methods: This cross-sectional study targeted 1193 residents of Naraha Town in Fukushima Prefecture.
Article Synopsis
- - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
- - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
- - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
Article Synopsis
- This study highlights the negative attitudes towards schizophrenia among various groups, including medical students, psychiatrists, and non-medical workers.
- An 18-item survey assessed factors like stigma and skepticism about treatment, revealing significant differences in discrimination scores.
- Findings show that psychiatrists had lower stigma levels compared to other groups, and medical students in their fourth year displayed higher underestimation of patients' abilities than those in their third year.
Article Synopsis
- The study investigates how family visits to psychiatric inpatients before evacuating due to the FDNPP accident influenced their return to Fukushima.
- It analyzed data from 44 patients who were evacuated on March 11, 2011, comparing return times between those who had family visits and those who did not.
- Results indicated that patients who received family visits returned to Fukushima significantly earlier, emphasizing the importance of family support for rehabilitation and reintegration after disasters.
Article Synopsis
- A gram-negative bacterium causes gastroenteritis, and although it can lead to bacteremia, spinal epidural abscess formation is rare and often overlooked.
- A case is reported of a 54-year-old immunocompromised woman who experienced severe back pain without gastrointestinal symptoms, later diagnosed with an L5/S1 spinal epidural abscess.
- This case emphasizes the necessity of using contrasted MRI for early and accurate diagnosis of spinal epidural abscesses, especially when gastrointestinal symptoms are absent.
Background: Proton pump inhibitors (PPIs), which inhibit gastric acid secretion, are frequently prescribed to patients with Parkinson's disease (PD). Levodopa, the gold-standard treatment for PD, demonstrates enhanced solubility in acidic environments. Although PPIs increase gastric pH and may affect levodopa absorption, the effect of concomitant PPI use on levodopa pharmacokinetics in patients with PD remains unknown.
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- - The AML-05 study focused on evaluating a risk-based treatment approach for children with acute myeloid leukemia (AML), determining that allogeneic hematopoietic cell transplantation (allo-HCT) wasn’t necessary for low- or intermediate-risk patients in their first complete remission.
- - A retrospective analysis identified key prognostic factors for survival in 79 pediatric patients who underwent allo-HCT, highlighting umbilical cord blood (UCB) as a particularly favorable donor source for low-risk patients, along with late relapse being advantageous for intermediate-risk patients.
- - The study found significant differences in three-year outcomes like overall survival (OS) and event-free survival (EFS) between low- and intermediate-risk groups, suggesting
Since the 2011 Fukushima nuclear power plant accident, multiple social network disruptions have been reported among the community in Fukushima, while posttraumatic stress symptoms among the residents have persisted. In this study, we aimed to explore the influence of time and social networks on the recovery of posttraumatic stress symptoms based on longitudinal data from community residents in Fukushima, following up five to ten years after the nuclear power plant accident. We conducted five questionnaire surveys quasi-annually, the targets of which were randomly sampled 4900 non-evacuee community residents.
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- A 76-year-old woman with ongoing diarrhea was hospitalized and found to have purpura, high eosinophil levels, and elevated IgG4 antibodies.
- CT scans showed large amounts of fluid in her abdomen and swelling in her intestines.
- Skin and gastrointestinal biopsies confirmed eosinophilic gastroenteritis and leukocytoclastic vasculitis but didn't meet criteria for IgG4-related disease, suggesting the connection between eosinophilic gastroenteritis and IgG4-related disease needs more research.
Mismatch negativity (MMN) is automatically elicited by incoming sound deviation compared to the neural representation of preceding homogenous sounds stored in the brain's auditory sensory memory. This study aimed to assess time-functional deviation sensitivity in auditory sensory memory associated with a temporal window of integration (TWI) of 160-170 msec in patients with schizophrenia. To this end, we measured the magnetic counterpart of the MMN (MMNm) in 20 patients with schizophrenia on medication and 20 healthy age-matched adults as a control group responding to an omitted tone segment incorporated into a complex sound of 176 ms duration corresponding to the TWI duration.
View Article and Find Full Text PDFHematopoietic stem cell transplants for inherited metabolic disorders performed at Tokai University Hospital between June 5, 1986, and May 28, 2021, were analyzed and compared between the period before 2007 and the period from 2007 onward based on availability of medical resources. Transplants were performed for 38 patients with mucopolysaccharidosis, 33 with adrenoleukodystrophy, and 16 with another disorder. Before 2007, oral busulfan-based regimens were mainly used.
View Article and Find Full Text PDFAim: This study aimed to clarify the abnormalities in dopamine transporter (DAT) availability in drug-naive adult patients with attention-deficit/hyperactivity disorder (ADHD) and the relationship between ADHD symptoms and abnormalities in DAT availability.
Methods: Single-photon emission tomography (SPECT) was performed using iodine-123-β-carbomethoxy-3β-(4-iodophenyltropane) (I-123 β CIT) as a tracer to measure in vivo DAT availability in 20 drug-naive patients with ADHD [mean age ± standard deviation (SD)]: 25 ± 3.44 years; male:female = 11:9] and 20 age- and sex-matched healthy controls (HCs) (mean age ± SD: 23.
Objectives: Disaster evacuation increases the risk of becoming overweight or obese owing to lifestyle changes and psychosocial factors. This study evaluated the effect of evacuation on becoming overweight during a 7-year follow-up among residents of Fukushima Prefecture during the Great East Japan Earthquake.
Study Design: This was a prospective cohort study.
Desiccation tolerance of pathogenic bacteria is one strategy for survival in harsh environments, which has been studied extensively. However, the subsequent survival behavior of desiccation-stressed bacterial pathogens has not been clarified in detail. Herein, we demonstrated that the effect of desiccation stress on the thermotolerance of O157:H7 in ground beef was limited, and its thermotolerance did not increase.
View Article and Find Full Text PDFBackground: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.
Methods: We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks.
Objective: Pemphigus Vulgaris (PV) is a rare autoimmune disease that could cause laryngeal lesions; however, only a few studies have described the localization of the laryngeal lesions associated with this disease owing to its rarity. Therefore, this study aimed to determine the localization of laryngeal lesions in patients with PV.
Methods: Fourteen patients with PV accompanied by laryngeal or pharyngeal lesions, who underwent flexible laryngeal endoscopy performed by laryngologists, were examined retrospectively.
Background: This study investigated changes of lipid parameters in children with severe eating disorders during refeeding in order to explore the optimal timing for lipid preparation administration.
Methods: We prospectively assessed the physical conditions of patients with eating disorders after the start of nutrition therapy. The assessments were performed at admission and at 2 and 4 weeks.
Protein arginine methyltransferase 5 (PRMT5) is a well-known epigenetic regulatory enzyme. However, the role of PRMT5-mediated arginine methylation in gene transcription related to cardiac fibrosis is unknown. Here we show that fibroblast-specific deletion of PRMT5 significantly reduces pressure overload-induced cardiac fibrosis and improves cardiac dysfunction in male mice.
View Article and Find Full Text PDFA teenage girl with systemic lupus erythematosus (SLE) was admitted with fever, dry cough, and dyspnea on exertion. Chest computed tomography revealed bilateral diffuse infiltration and swelling of the mediastinal lymph nodes. The bronchoalveolar lavage (BAL) fluid was light red, suggesting diffuse alveolar hemorrhage (DAH).
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- Dopamine transporter SPECT (DAT-SPECT) is essential for diagnosing Parkinson's disease (PD), but its accuracy can vary across different clinical sites, posing challenges in multisite trials.
- Both prospective linear regression and retrospective statistical correction (ComBat) methods were tested to improve the accuracy of DAT-SPECT measurements in distinguishing PD patients from healthy controls.
- Results indicated that while both correction methods improved diagnostic performance, the ComBat correction achieved comparable accuracy to the prospective method, suggesting it could be an effective alternative for addressing site-related variability.