Effects of naloxone and flumazenil on antinociceptive action of acetaminophen in rats.

Background: Studies of acetaminophen suggest that multiple nociceptive pathways are involved in the drug's analgesic action.

Objective: The purpose of this study was to determine whether naloxone and flumazenil were able to modify or antagonize the antinociceptive effect of acetaminophen in rats.

Methods: Adult albino Wistar rats were used in the study and randomly allocated to 1 of 4 groups.

Interaction between venlafaxine and caffeine on antinociception in mice.

This study was conducted in order to evaluate whether or not caffeine has any effect on venlafaxine antinociception in mice in acute application. Swiss albino mice, both male and female, were tested with hot plate analgesiameter set at 52.5 +/- 0.

Inhibitory effects of desflurane and sevoflurane on contractions of isolated gravid rat myometrium under oxytocin stimulation.

Background: We studied the inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated gravid rat myometrium.

Methods: Twenty strips were obtained from rats and these were randomly assigned into two groups. The effects of desflurane and sevoflurane were evaluated by treating strips with oxytocin alone 2x10-9 M or with oxytocin after desflurane and sevoflurane at 0.