Photocatalyst-free formate-mediated C-O cleavage by the EDA complex and SCS strategy for the synthesis of diaryl 1,4-diketone in air.

Under mild visible light conditions, formates facilitate C-O cleavage the EDA complex and SCS strategy, yielding α-carbonyl alkyl radicals. These radicals then react with olefins under air conditions, leading to the synthesis of diaryl 1,4-dicarbonyl compounds. Mechanistic studies reveal that α-formyloxy ketone is generated by the reaction between α-brominated acetophenone and formates, followed by the formation of the EDA complex.

Stress-responsive plasma membrane H-ATPases regulate deep rooting in rice.

Agricultural production is severely affected by environmental stresses such as drought, and deep rooting is an important factor enhancing crop drought avoidance. H-ATPases provide a transmembrane proton gradient and are thought to play a crucial role in plant growth and abiotic stress responses. However, their expression under abiotic stress and function on deep rooting is poorly understood in rice.

Hybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation.

Tumor hypoxia is a critical driver of cancer progression, metastasis, and therapy resistance, posing significant challenges in effective cancer treatment. Hypoxia-activable prodrugs offer a promising strategy to target tumors in low-oxygen conditions, but their efficacy is often hindered by intrinsic properties and extrinsic cues. In this study, we developed a dual-prodrug nanoassembly system (CPPA) composed of a hypoxia-triggerable camptothecin (CPT)-based dimeric prodrug (CP) and a lipid-conjugated STAT3 antisense oligonucleotide (ASO) prodrug (PA), aiming to enhance tumor-targeted chemotherapy and overcome the immune evasion within the tumor microenvironment.

Aluminum Cluster Molecular Ring-Based Heterometallic Framework Materials for Iodine Capture.

With the development of the nuclear industry, the risk of elements that are difficult to degrade in nuclear fission has been gradually increasing. Therefore, the efficient capture of iodine (I) has attracted considerable attention in recent years. The aluminum cluster-based metal framework materials show great advantage in iodine adsorption due to the designable pore sizes, excellent physicochemical stability, and cheap raw materials.

A novel approach for agricultural carbon emission reduction by integrating fermatean neutrosophic set with WINGS and AHP-EWM.

Agriculture is a major contributor to global greenhouse gas emissions, highlighting the urgent need for effective carbon reduction strategies. This study presents an innovative integrated model that employs Fermatean Neutrosophic Set in conjunction with the Weighted Influence Nonlinear Gauge System and the Analytic Hierarchy Process combined with the Entropy Weight Method to assess key factors influencing agricultural carbon reduction. Our study delineates the hierarchical importance of factors influencing carbon emissions, with carbon emission reduction policy (τ4) emerging as the paramount factor, attributed a value of 0.

Substrate-Mediated Growth of Au Nanowires Under Weak CTAB Control and Rapid Au Deposition.

The selective Au deposition at the Au-substrate interface is known to give ultrathin Au nanowires and the synthesis usually employs strong thiol-based ligands. It is shown that, by increasing the rate of Au deposition, weak cetyltrimethylammonium bromide (CTAB) can be made to behave like a strong ligand, so that it induces Active Surface Growth and gives Au nanowires. The ligand strength also depends on the packing interactions in the ligand layer, in the order of CTAB, CTAB, and CTAB.

Corticosteroids plus metformin versus corticosteroids as front-line treatment for patients with newly diagnosed ITP and pre-existing type 2 diabetes mellitus: A multicentre propensity score-matched study.

Corticosteroids are the standard first-line treatment for primary immune thrombocytopenia (ITP), with a high initial response but unsatisfactory sustained response (SR). Additionally, corticosteroids usually lead to hyperglycaemia especially in patients with pre-existing type 2 diabetes mellitus (T2DM). Besides reducing the blood glucose levels, metformin was found to have immunomodulatory effects.

Relatively lower BMI-adjusted calf circumference is associated with metabolically unhealthy phenotype in non-obese adults: a cross-sectional study.

Background: Metabolically unhealthy non-obese (MUNO) individuals are at higher risk of cardiovascular diseases, while not receiving sufficient attention. This study was conducted to explore the association between BMI-adjusted CC and MUNO in non-obese US adults using the NHANES database.

Methods: A total of 9,628 non-obese US adults (48.

Gold(I) complexes bearing EGFR-inhibiting ligands as anti-HCC agents through dual targeting of EGFR and TrxR.

Overexpression of epidermal growth factor receptor (EGFR) and thioredoxin reductase (TrxR) are commonly associated with an adverse prognosis in hepatocellular carcinoma (HCC). This makes them key targets for the treatment of HCC. Studies have shown that the clinical efficacy of the EGFR tyrosine kinase inhibitor gefitinib alone in treating HCC is limited.

Predicting and optimizing pure electric vehicle road noise via a locality-sensitive hashing transformer and interval analysis.

Pure electric vehicles (PEVs) lack engine noise; thus, the overall noise level within vehicle cabins are reduced. However, due to the absence of engine noise, previously overlooked noise sources are accentuated and detrimentally affect interior noise quality. Road noise is a predominant PEV noise source and significantly contributes to middle- and low-frequency interior noise levels.

Erlotinib-Gold(I) Complex Induces Leukemia Cell DC Differentiation and Remodels the Immunosuppressive Microenvironment.

Inducing differentiation of leukemia cells into dendritic cells (DC) is pivotal to reshaping the immunosuppressive microenvironment. Here, we report the synthesis of , an erlotinib-gold(I) complex, which directly prompts the differentiation of acute myeloid leukemia (AML) cells into DCs. A patient-derived xenograft (PDX) model underscores the potent anti-AML activity of .

Colloidal substrate-facilitated synthesis of gold nanohelices.

Helical nanostructures have unique optical and mechanical properties, yet their syntheses had always been quite challenging. Various symmetry-breaking mechanisms such as chiral templates, strain-restriction and asymmetric ligand-binding have been developed to induce the helical growth at nanoscale. In this work, with neither chiral ligands nor templates, gold (Au) nanohelices were synthesized via a facile wet-chemical method, through an asymmetric Active Surface Growth facilitated by colloidal silica nanoparticles (NPs).

An HPQ-based near-infrared dye for the detection of ClO and accurate imaging of cells and mouse tumor sites .

A new fluorescent probe (SWJT-32) with a large Stokes shift was designed and synthesized with 2-(2-hydroxyphenyl)-4(1)-quinazolinone (HPQ) as the skeleton and ,-dimethylthiocarbamate as the recognition site. It can detect hypochlorite ions (ClO) through fluorescence spectroscopy based on the excited-state intramolecular proton transfer (ESIPT) and intramolecular charge transfer (ICT) mechanism. The probe has the advantages of strong diffusion resistance, good photostability and selectivity, and high imaging contrast, and can be used for the detection of ClO.

Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment.

Background: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged 1-3 years with PWS.

Methods: Data was gathered for individuals with PWS aged 1-3 years who received two or more Hemoporfin-PDT treatments.

Enrichment and catalysis effect of 2D/2D g-CN/TiC for promoting organic matter degradation and heavy metal reduction in plasma systems: Unveiling the promotion and redox mechanism.

This work proposes a novel plasma-assisted 2D/2D g-CN/TiC system for treatment of organics-heavy metals composite wastewater. Unlike traditional materials in plasma system, 2D/2D g-CN/TiC not only improved the mass transfer efficiency of plasma by gathering both reactive species and pollutants onto the surface, but also induced photocatalytic reactions. Besides, the higher specific surface area and faster carrier separation rate can enhance the oxidation and reduction activity, and then promoted organic matter degradation and heavy metal reduction.

IGF2BP1 promotes multiple myeloma with chromosome 1q gain via increasing CDC5L expression in an mA-dependent manner.

Multiple myeloma (MM) patients with chromosome 1q gain (1q+) are clinically and biologically heterogeneous. The underlying molecular mechanisms are still under investigation, while the identification of targets for effective therapy of this subgroup of MM patients is urgently needed. We aimed to investigate the clinical significance and the regulatory mechanisms of insulin-like growth factor 2 messenger RNA (mRNA) binding protein 1 (IGF2BP1), a N6-methyladenosine (mA) reader, in MM patients with 1q+.

GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects.

Background: The process of bone healing is complex and involves the participation of osteogenic stem cells, extracellular matrix, and angiogenesis. The advancement of bone regeneration materials provides a promising opportunity to tackle bone defects. This study introduces a composite hydrogel that can be injected and cured using UV light.

Association of nirmatrelvir-ritonavir with post-acute sequelae and mortality among patients who are immunocompromised with COVID-19 in Hong Kong: a retrospective cohort study.

Background: The effect of nirmatrelvir-ritonavir on post-COVID-19 outcomes for individuals who are immunocompromised is understudied. We aimed to examine the association of nirmatrelvir-ritonavir with post-acute sequelae and mortality among patients who are immunocompromised and admitted to hospital with COVID-19.

Methods: We did a retrospective cohort study using territory-wide electronic health records from the Hong Kong Hospital Authority and Hong Kong Department of Health.

Three-dimensional structured PLCL/ADM bioactive aerogel for rapid repair of full-thickness skin defects.

The failure to treat deep skin wounds can result in significant complications, and the limitations of current clinical treatments highlight the pressing need for the development of new deep wound healing materials. In this study, a series of three-dimensional structured PLCL/ADM composite aerogels were fabricated by electrospinning and subsequently characterized for their microstructure, compression mechanics, exudate absorption, and hemostatic properties. Additionally, the growth of HSFs and HUVECs, which are involved in wound repair, was observed in the aerogels.

Osteocalcin and Chinese visceral adiposity index are associated with the risk of ASCVD and arterial stiffness in patients with T2DM.

This study aims to discover the association between serum osteocalcin, the Chinese visceral adiposity index (CVAI), and atherosclerotic cardiovascular disease (ASCVD) risk, and their impact on arterial stiffness in T2DM patients. We included 639 T2DM patients aged 30 and older who received the assessment of ASCVD risk using the China-PAR equation, Osteocalcin and arterial stiffness in this cross-sectional study. We found that osteocalcin and CVAI as independent risk factors for both medium-high-risk ASCVD (osteocalcin: men, OR,0.

COVID-19 vaccination modified the effect of nirmatrelvir-ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study.

While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This study examined the interaction between nirmatrelvir-ritonavir and complete COVID-19 vaccination on reducing the risk of post-acute outcomes among COVID-19 patients. We followed COVID-19 patients hospitalized between 11 March 2022 and 10 October 2023, until 31 October 2023 in Hong Kong.

Biocatalytic degradation of environmental endocrine disruptor chlorobenzene via surfactant-optimized laccase-mediator system.

The emergence of environmental endocrine disruptor chlorobenzene (CB) in surface water and its potential environmental impacts have attracted serious global attention. It is still very difficult to achieve effective degradation of it by catalytic oxidation process under mild conditions. Here, an optimized method for degrading CB in aqueous solution using laccase and surfactant-assisted laccase-mediator (SALM) system was investigated.