Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings.

Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, and due to their unique structures, high bioactivities, and excellent designability characteristics, an increasing number of studies have been devoted to modifying these species to generate novel composites with desirable optical, electrical, and magnetic properties. However, few systematic and detailed reviews have been performed relating to the modification approaches available for MNPs and their resulting composites. In this review, a comprehensive summary is performed regarding the optimized modification formulations of MNPs for application in wound dressings, and the techniques used to prepare composite wound dressings are discussed.

3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression.

Colorectal carcinoma (CRC) is a deadly cancer with an aggressive nature, and how CRC tumor cells manage to translocate and proliferate in a new tissue environment remains not fully understood. Recently, higher-order chromatin structures and spatial genome organization are increasingly implicated in diseases including cancer, but in-depth studies of three-dimensional genome (3D genome) of metastatic cancer are currently lacking, preventing the understanding of the roles of genome organization during metastasis. Here we perform multi-omics profiling of matched normal colon, primary tumor, lymph node metastasis, liver metastasis and normal liver tissue from CRC patients using Hi-C, ATAC-seq and RNA-seq technologies.

Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis.

Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on muscle regeneration after injury through the regulation of antioxidant capacity and mitochondrial biogenesis. RES treatment significantly increased the ratio of tibialis anterior muscle mass to body weight, alongside reduced fasting glucose levels.

Development of colloidal carbon-based immunoassay for the determination of thiamethoxam in medicinal and edible Lonicerae Japonicae Flos.

Thiamethoxam is one of the top three neonicotinoids found in the environment and in food. The widespread use of thiamethoxam in medicinal and edible herbs threatens their safe use. Therefore, it is particularly important to develop a rapid and simple approach to detect thiamethoxam residues in herbal medicines.

Design Strategies and Application Potential of Multifunctional Hydrogels for Promoting Angiogenesis.

Hydrogels can be rationally designed as multifunctional platforms with structures and functions for various biomedical applications. Because of their excellent biochemical and mechanical properties, hydrogels have shown great potential for promoting angiogenesis, and an increasing amount of research has been devoted to designing and developing new hydrogels. However, a systematic and detailed review of hydrogels that promote angiogenesis is lacking.

Osimertinib treatment response in a patient with lung adenocarcinoma harboring two rare EGFR mutations: A case report.

Epidermal growth factor receptor () mutations have emerged as the most well-studied oncogenic alterations in advanced non-small cell lung cancer. The presence of single common or rare mutations and extra complex mutations correlates with the response sensitivity to tyrosine kinase inhibitors. Therefore, given the lack of evidence for the emergence of rare mutation types, the pathogenic mechanisms of uncommon mutations and the optimal treatment strategies remain to be explored further.

Genetic prediction of asthma increases multiple sepsis risks: A Mendelian randomization study.

Background: Observational epidemiological studies have indicated a potential association between asthma and sepsis, although the causal relationship between these 2 conditions remains uncertain. To further investigate this relationship, the present study utilized Mendelian randomization (MR) analysis approach to explore the potential links between asthma and various types of sepsis.

Methods: In a large-scale genome-wide association study, single nucleotide polymorphisms (SNPs) associated with asthma were selected as instrumental variables.

Cognitive changes in professional value and career development amid the COVID-19 pandemic: A qualitative study of nurses' experiences.

Aim: To explore cognitions in nurses' professional value and career development amid the COVID-19 pandemic and to analyse influencing factors.

Design: A qualitative descriptive study design was employed.

Methods: Thirty practising nurses from three general hospitals in Chengdu, China, were purposively recruited.

A comprehensive benchmarking with interpretation and operational guidance for the hierarchy of topologically associating domains.

Topologically associating domains (TADs), megabase-scale features of chromatin spatial architecture, are organized in a domain-within-domain TAD hierarchy. Within TADs, the inner and smaller subTADs not only manifest cell-to-cell variability, but also precisely regulate transcription and differentiation. Although over 20 TAD callers are able to detect TAD, their usability in biomedicine is confined by a disagreement of outputs and a limit in understanding TAD hierarchy.

Celosia cristata L.: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and quality control, along with network pharmacological analysis of its components and targets.

Ethnopharmacological Relevance: Celosia cristata L. (C. cristata) is a widely used herb in China and has been used as a medicine for more than 1000 years.

Sensitivity and stability improvement on slippery surface-aggregated substrate for trace heavy metals detection using NELIBS.

The sensitive and stable detection of trace heavy metals in liquid is crucial given its profound impact on various aspects of human life. Currently, nanoparticle-enhanced laser-induced breakdown spectroscopy (NELIBS) with dried droplet method (DDM) is widely applied for heavy metals detection. Nevertheless, the coffee ring effect (CRE) in DDM affects the stability, accuracy, and sensitivity of NELIBS.

Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7.

Disialosyl globopentaosylceramide (DSGb5) is a tumor-associated complex glycosphingolipid. However, the accessibility of structurally well-defined DSGb5 for precise biological functional studies remains challenging. Herein, we describe the first total synthesis of DSGb5 glycolipid by an efficient chemoenzymatic approach.

[Mercury species analysis and tissue distribution in rats after continuous administration of Cinnabaris].

Cinnabaris is a traditional Chinese medicine(TCM) commonly used for sedation and tranquilization in clinics, and its safety has always been a concern. This study intends to investigate the species and tissue distribution of mercury in rats after continuous administration of Cinnabaris. In the experiment, 30 rats were randomly divided into the control group(equivalent to 0.

Acute-on-chronic liver failure induced by antiviral therapy for chronic hepatitis C: A case report.

Background: There have been no reports of acute-on-chronic liver failure (ACLF) during treatment of chronic hepatitis C (CHC) with direct-acting antivirals (DAAs).

Case Summary: We report a 50-year-old male patient with CHC. The patient sought medical attention from the Department of Infectious Diseases at our hospital due to severe yellowing of the skin and sclera, which developed 3 mo previously and attended two consecutive hospitals without finding the cause of liver damage.

Nitrogen and sulfur co-doped carbon quantum dots as "on-off-on" fluorescence probes to detect Hg and MnO and improving the photostability of Rhodamine B.

Background: Carbon quantum dot (CQDs) are zero-dimensional carbon nanomaterials with a size of less than 10 nm CQDs are widely used in the field of ion detection by virtue of their fluorescence characteristics such as strong fluorescence intensity, good optical stability and tunable emission wavelength. Although the traditional atomic absorption method, electrochemical method and other metal ion detection methods are highly sensitive, the operation is complex, expensive and limited by the site. Therefore, we prepared the N, S-CQDs capable of detecting Hg and MnO in water with the advantages of simple operation, low cost, and direct visual signal.

"Two Birds One Stone" Strategy for the Site-Specific Analysis of Core Fucosylation and -GlcNAcylation.

Core fucosylation and -GlcNAcylation are the two most famous protein glycosylation modifications that regulate diverse physiological and pathological processes in living organisms. Here, a "two birds one stone" strategy has been described for the site-specific analysis of core fucosylation and -GlcNAcylation. Taking advantage of two mutant endoglycosidases (EndoF3-D165A and EndoCC-N180H), which efficiently and specifically recognize core fucose and -GlcNAc, glycopeptides can be labeled using a biantennary -glycan probe bearing azido and oxazoline groups.

Vitamin D supplementation improved physical growth and neurologic development of Preterm Infants receiving Nesting Care in the neonatal Intensive Care Unit.

Objective: To study the effects of vitamin D supplementation on physical growth and neurologic development of very preterm infants receiving nesting intervention in the neonatal intensive care unit (NICU).

Methods: A total of 196 preterm infants had been hospitalized in NICU with the gestational age (GA) between 28 and 32 weeks. Among them, 98 preterm infants received nesting intervention, and the other 98 cases received both nesting and vitamin D supplementation (400 IU).

Chemoenzymatic Total Synthesis of Lipooligosaccharide Core Octasaccharides Containing Natural and Unnatural Sialic Acids.

The first total synthesis of lipooligosaccharide core octasaccharides containing natural and unnatural sialic acids has been achieved by an efficient chemoenzymatic approach. A highly convergent [3 + 3] coupling strategy was developed to chemically assemble a unique hexasaccharide bearing multiple rare higher-carbon sugars d-glycero-d-manno-heptose (d,d-Hep), l-glycero-d-manno-heptose (l,d-Hep), and 3-deoxy-α-d-manno-oct-2-ulosonic acid (Kdo). Key features include sequential one-pot glycosylations for oligosaccharide assembly and the construction of the challenging α-(1 → 5)-linked Hep-Kdo glycosidic bond by gold-catalyzed glycosylation with a glycosyl -alkynylbenzoate donor.

Efficient removal of phytochrome using rice straw-derived biochar: Adsorption performance, mechanisms, and practical applications.

Rice straw derived biochar was fabricated and applied as a purification agent. The adsorption kinetics, isotherms, and thermodynamics for adsorbates were determined using the biochar. Adsorption kinetics and isotherms were best fitted by the pseudo-second order and Langmuir models.

Further insight into the potential toxicity of zearalenone-14-glucoside based on toxicokinetics, tissue distribution, transformation, and excretion in rats.

Bioaccumulation and biotransformation are critical factors that affect the release of easily metabolizable chemicals to cause human toxicity. The glucoside-type modified mycotoxin Zearalenone-14-Glucoside (Z14G) has attracted global attention for its high occurrence in foodstuffs and the potential threat to humans as its high rate of transformation into parent forms. Given the limited toxicokinetics information, this study assessed the absorption, distribution, biotransformation and excretion of Z14G, aiming to define the potential risk of Z14G.

A Sensitive and Reversible Labeling Strategy Enables Global Mapping of the Core-Fucosylated Glycoproteome on Cell Surfaces.

Core fucosylation, the attachment of α1,6-fucose to the innermost N-acetylglucosamine (GlcNAc) residue of N-glycans, has a strong relationship with tumor growth, invasion, metastasis, prognosis, and immune evasion by regulating many membrane proteins. However, details about the functional mechanism are still largely unknown due to the lack of an effective analytical method to identify cell-surface core-fucosylated glycoproteins, and especially glycosylation sites. Here, we developed a sensitive and reversible labeling strategy for probing core fucosylation, by which core-fucosylated glycoproteins that located on cell-surface were selectively tagged by a biotinylated probe with high sensitivity.

Pyrolae herba: A review on its botany, traditional uses, phytochemistry, pharmacology and quality control.

Ethnopharmacological Relevance: Pyrolae herba is the dried whole plant of Pyrola calliantha H. Andres or Pyrola decorata H. Andres (Pyrolaceae).

The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.

In the past year, the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the worldwide coronavirus disease 2019 (COVID-19) pandemic. Yet our understanding of the SARS-CoV-2 tropism mechanism is still insufficient. In this study, we examined the chromatin accessibility at the promoters of host factor genes (, , , , , and ) in 14 tissue types, 23 tumor types, and 189 cell lines.