GLP-1 Receptor Agonists Alleviate Diabetic Kidney Injury via β-Klotho-Mediated Ferroptosis Inhibition.

Semaglutide (Smg), a GLP-1 receptor agonist (GLP-1RA), shows renal protective effects in patients with diabetic kidney disease (DKD). However, the exact underlying mechanism remains elusive. This study employs transcriptome sequencing and identifies β-Klotho (KLB) as the critical target responsible for the role of Smg in kidney protection.

Preoperative resting-state electrophysiological signals predict acute but not chronic postoperative pain.

Background: The prevalence of postoperative pain is notably high among the elderly population, which poses significant challenges for their postoperative recovery. In this study, we aimed to identify preoperative predictors for acute and chronic postoperative pain in patients undergoing lumbar spinal surgery through a longitudinal investigation.

Methods: We recruited 75 patients (mean age 68.

Argonaute-Based Nucleic Acid Detection Technology: Advantages, Current Status, Challenges, and Perspectives.

Rapid and accurate detection is a prerequisite for precise clinical diagnostics, ensuring food safety, and facilitating biotechnological applications. The Argonaute system, as a cutting-edge technique, has been successfully repurposed in biosensing beyond the CRISPR/Cas system (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins), which has been extensively researched, but recognition of PAM sequences remains restricted. Argonaute, as a programmable and target-activated nuclease, is repurposed for fabricating novel detection methods due to its unparalleled biological features.

Plasma Tailoring of NH-MIL-53 with Enhanced Fluorescence Emission for Simultaneous Detection of Multiple Heavy Metals in Water.

Indium, copper, and mercury are important raw materials in the electronics industry and often coexist in factory wastewater. Therefore, the development of a highly sensitive and selective method for the simultaneous detection of these heavy metal ions is of great significance for water quality monitoring and environmental protection. Herein, we report a NH-MIL-53 fluorescent probe for the simultaneous detection of trace In, Cu, and Hg in water.

Construction of a Home Hospice Care Program for Older Adults at the End of Life with Chronic Diseases in China: A Delphi Method.

Purpose: With the increasing aging of the population and the increasing incidence of chronic diseases in China, home hospice care services can meet the desire of the older adult with chronic diseases to receive care and die at home. In order to ensure the real application of hospice in families, the goal of the study was to construct a home hospice care program for the older adult at the end of life with chronic diseases based on Harmony Nursing Theory (composed of three parts: harmony needs assessment, harmony mechanism establishment and interpersonal interaction).

Methods: Through literature review, a qualitative interview and group discussion, the first draft of a home hospice care program for the older adult at the end of life with chronic diseases based on the harmony nursing theory was developed, which was further revised and finalized by combining the Delphi method of expert correspondence with 19 experts and a pilot study with a home hospice care team.

Enhancing training transfer among stroke specialist nurses: Insights from latent profile analysis.

Aim: Using Latent Profile Analysis (LPA) to identify distinct categories within stroke specialist nurses training transfer and to explore the factors influencing these categories.

Background: Stroke represents a significant worldwide health challenge. During the treatment and rehabilitation of stroke, stroke specialist nurses play an essential role.

Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo.

In mammals, during the post-fertilization pre-implantation phase, the expression of cell type-specific genes is crucial for normal embryonic development, which is regulated by cis-regulatory elements (CREs). TFs control gene expression by interacting with CREs. Research shows that transcription factor binding sites (TFBSs) reflect the general characteristics of the regulatory genome.

CRISPR/Cas and Argonaute-powered lateral flow assay for pathogens detection.

Pathogens contamination is a pressing global public issue that has garnered significant attention worldwide, especially in light of recent outbreaks of foodborne illnesses. Programmable nucleases like CRISPR/Cas and Argonaute hold promise as tools for nucleic acid testing owning to programmability and the precise target sequence specificity, which has been utilized for the development pathogens detection. At present, fluorescence, as the main signal output method, provides a simple response mode for sensing analysis.

Improved HER/OER Performance of NiS/MoS Composite Modified by CeO and LDH.

In recent years, there has been significant interest in transition-metal sulfides (TMSs) due to their economic affordability and excellent catalytic activity. Nevertheless, it is difficult for TMSs to achieve satisfactory performance due to problems such as low conductivity, limited catalytic activity, and inadequate stability. Therefore, a catalyst with a heterostructure constituted of a nickel-iron-layered double hydroxide, nickel sulfide, molybdenum disulfide, and cerium dioxide was designed.

Development of a chemiluminescent immunoassay based on magnetic solid phase for quantification of homocysteine in human serum.

Background: Homocysteine (HCY) is a sulfur-containing amino acid that is an independent or important risk factor for the occurrence of many chronic diseases and is one of the most important indicators for determining health risks. However, existing HCY detection methods do not meet the requirements of clinical diagnosis. Therefore, there is an urgent need to establish new detection methods to meet the needs of clinical detection.

Development and validation of the job stressor scale for specialty nurses.

Objectives: Specialty nurses play a crucial role in specialized nursing practice, teaching, management, and research. These nurses often face significant work pressure; therefore, scientifically and effectively assessing their job stress and its sources is vital for enhancing the quality of their work. However, there is currently a dearth of verified assessment tools for measuring job stressors among specialty nurses.

Influence of the Hierarchy Structure of Aluminum Particles on Density, Combustion Efficiency, and Ignition Delay.

Aluminum nanoparticles (nAl) have received sustained interest due to their higher reactivity than micron aluminum particles (mAl). However, in practice, the densities of explosive formulations with nAl are far smaller than those with mAl, which greatly undercuts the energy release performance. To take advantages of both kinds of Al particles, in situ integration of mAl@nAl composites was proposed and evaluated.

Triggering multiple modalities of cell death via dual-responsive nanomedicines to address the narrow therapeutic window of β-lapachone.

The clinical translation of the anticancer drug β-lapachone (LAP) has been limited by the narrow therapeutic window. Stimuli-responsive anticancer drug delivery systems have gained tremendous attention in recent years to alleviate adverse effects and enhance therapeutic efficacy. Here, we report a dual pH- and enzyme-responsive nanocarrier to address the above issue of LAP.

Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial.

Background And Aims: Whole grain consumption is widely recognized as a vital component of a balanced diet. Dietary fiber has been well-documented to play a crucial role in these health benefits attributed to whole grain intake. However, population-based evidence directly linking whole grain consumption to anti-inflammatory effects, especially in the context of immune-mediated inflammation, remains limited.

Morphological study of remineralization of the eroded enamel lesions by tyrosine-rich amelogenin peptide.

Background: Tyrosine-rich amelogenin peptide (TRAP) is the main amelogenin digestion product in the developmental enamel matrix. It has been shown to promote remineralization of demineralized enamel in our previous study. However, direct evidence of the effect of TRAP on the morphology and nanostructure of crystal growth on an enamel surface has not been reported.

Survey of role stress among specialty nurses working in tertiary general hospitals across China: a cross-sectional descriptive study.

Background: Occupational stress can affect specialty nurses' quality of work, especially for those working in care units. This study, therefore, investigated role stress and its related factors among specialty nurses working in tertiary general hospitals.

Methods: This cross-sectional descriptive study used convenience sampling to recruit 795 Chinese specialty nurses in 11 tertiary general hospitals (from February to March 2023).

Linkage between role stress and work engagement among specialty nurses: a cross-sectional study of China.

Objectives: Specialty nurses play a significant role in improving patient care; however, little is known about the factors affecting their work engagement. This study aimed to explore the relationship between role stress and work engagement among specialty nurses in China.

Design: A descriptive, cross-sectional study was applied in this study.