Arnebinfuranoids A-G, seven unique heterodimers of meroterpenoids from Arnebia euchroma.

Seven previously undescribed heterodimers (1-7) with unusual carbon-carbon bond linkages for monomeric meroterpenoids and a known compound (8) were isolated from the roots of Arnebia euchroma (Royle) Johnst. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of electronic circular dichroism spectra. Further careful NMR analysis revealed that the chemical shift differences of the methylene protons affected by remote chirality were related to the relative configurations of the heterodimers (1-6).

Enhancing the Performance of Fluorinated Graphdiyne Moisture Cells via Hard Acid-Base Coordination of Aluminum Ions.

Moisture-enabled electric generators (MEGs) are emerging as a transformative energy technology, capable of directly converting ambient moisture into electrical energy without producing pollutants or harmful emissions. However, the widespread application of MEGs is hindered by challenges such as intermittent output and low current densities, which limit power density and prevent large-scale integration. Here, a novel moisture cell based on Al ion-F coordination-specifically, a fluorinated graphdiyne (FGDY) Al-ion moisture cell (FGDY AlMC) is introduced.

Toll-Like Receptor 7 Promotes Periodontal Inflammation and Alveolar Bone Resorption Through the NF-κB Signaling Pathway.

Aim: To investigate the role of Toll-like receptor 7 (TLR7) in periodontitis and its potential mechanisms.

Methods: TLR7 expression in periodontal tissues was analyzed using GEO database single-cell sequencing data and confirmed with gingival samples from healthy individuals and periodontitis patients. In vivo, a mouse model of periodontitis was used to assess the effect of M5049, the TLR7's inhibitor, on alveolar bone loss and inflammation.

Spatial metabolomics revealed multi-organ toxicity and visualize metabolite changes induced by borneol in zebrafish.

This study focuses on the potential hazards of borneol (BO) to aquatic organisms and human health. BO has antibacterial, anti-inflammatory and antioxidant activities, and is widely used in medicine, cosmetics, and detergents. In this study, zebrafish was used as a model organism to systematically evaluate the effects of BO on the heart, liver, kidney, and nervous system.

Optimizing the pore environment in biological metal-organic frameworks through the incorporation of hydrogen bond acceptors for inverse ethane/ethylene separation.

The development of efficient adsorbents for the selective separation of ethane (CH) and ethylene (CH) is essential for the cost-effective production of high-purity ethylene. Here, we employ a pore engineering strategy to optimize the pore environment of biological metal-organic frameworks (MOFs) by incorporating hydrogen bond receptors to enhance the inverse separation efficiency of CH and CH. Compared to the isomorphic Cu-AD-SA, the methyl-functionalized Cu-AD-MSA and Cu-AD-DMSA not only provide suitable pore confinement but also offer additional binding sites, thus creating an optimal environment for strong interactions with CH (AD = adenine, SA = succinic acid, MSA = 2-methylsuccinic acid, and DMSA = 2,2-dimethylsuccinic acid).

Megastigmane glycosides from Heterosmilax yunnanensis and their neuroprotective activity.

Ten previously undescribed megastigmane glycosides (1-5, 8-12) and four known compounds (6-7, 13-14) were isolated from the roots of Heterosmilax yunnanensis Gagnep. Their planar structures were determined by NMR, HRESIMS, UV and IR spectroscopic data. The absolute configurations were established through Rh(OCOCF)-induced ECD, quantum computational chemistry, experimental ECD and C chemical shift.

CMCS-PVA@CA hydrogel dressing: A promoter of wound healing with MRSA virulence attenuation function.

Traditional wound dressings, primarily centered on antimicrobial or bactericidal strategies, have inadvertently contributed to the rise of drug-resistant bacterial colonies at wound sites, thus prolonging the healing process. In this study, we developed an innovative hydrogel dressing, CMCS-PVA@CA, incorporating carboxymethyl chitosan (CMCS), polyvinyl alcohol (PVA), and cichoric acid (CA), specifically designed to treat skin wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Computational biology analyses reveal that CA exerts substantial anti-virulence activity by targeting serine/threonine phosphatase (Stp1), achieving an IC of 3.

ATG9 promotes autophagosome formation through interaction with LC3.

The autophagosome is a double-membrane organelle that executes macroautophagy. Previous studies have shown that the autophagosome formation is driven by autophagy-related genes, among which ATG9 is the only conserved transmembrane protein and has been shown to play a critical role in the autophagosome formation. However, how ATG9 binds to the growing autophagosome membrane has remained uncertain.

Regulation of Isoleucine on Colonic Barrier Function in Rotavirus-Infected Weanling Piglets and Analysis of Gut Microbiota and Metabolomics.

Rotavirus (RV) is a significant contributor to diarrhea in both young children and animals, especially in piglets, resulting in considerable economic impacts on the global pig industry. Isoleucine (Ile), a branched-chain amino acid, is crucial for regulating nutrient metabolism and has been found to help mitigate diarrhea. This study aimed to assess the impact of isoleucine supplementation in feed on colonic barrier function, colonic microbiota, and metabolism in RV-infected weanling piglets.

Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation.

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

Cyanidin-3-rutinoside from Mori Fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway.

Dyslipidemia is responsible for pathologies of cardiovascular diseases and gut microbiota plays an essential role in lipid metabolism. Dietary supplementation is an important supplement to medicine in management of dyslipidemia. Mori Fructus is a popular Asia medical food with various pharmacological benefits including anti-hyperlipidemia.

alleviates LPS-induced depressive behavior via enhancing the abundance of spp.

The rising incidence rate of depression presents a substantial threat to human well-being. (ST), the dried mature seeds of L., has a long-standing traditional reputation for alleviating anxiety and hopelessness.

Nanopore-Based Sequencing of the Full-Length Transcriptome of Male and Female Cleavage-Stage Embryos of the Chinese Mitten Crab ().

The cleavage stage plays a crucial role in embryo development, characterized by a swift surge in cell proliferation alongside the accurate genetic material transmission to offspring. To delve into the characteristics of sex development during the cleavage stage of embryos, we generated the full-length transcriptome of male and female cleavage-stage embryos using Oxford Nanopore Technologies (ONT). Notably, this investigation represents the first sequencing effort distinguishing between genders in embryos.

IMM2520, a novel anti-CD47/PD-L1 bispecific antibody for cancer immune therapy.

PD-1/PD-L1 is an important signaling pathway in the adaptive immune system. The CD47/SIRPα signaling pathway is a crucial "do not eat me" signal for innate immunity. This study evaluated the anti-tumor mechanism of IMM2520 and .

A sample of the Moon's far side retrieved by Chang'e-6 contains 2.83-billion-year-old basalt.

Remote sensing observations have shown that the far side of the Moon (lunar farside) has different geology and rock composition to those of the nearside, including the abundances of potassium, rare earth elements, and phosphorus (collectively known as KREEP). The Chang'e-6 (CE-6) spacecraft collected samples from the South Pole-Aitken (SPA) basin on the farside and brought them to Earth. We used lead-lead and rubidium-strontium isotope systems to date low-titanium basalt in a CE-6 sample, finding a consistent age of 2830 (±5) million years.

Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation Mechanism of Epididymis Sperm Maturation in Tibetan Sheep.

In this study, the epididymal histology, caepididymal sperm physiological parameters, serum reproductive hormones, and antioxidant enzyme SOD levels of Tibetan sheep at a 2500 m and 3500 m altitude were compared by using a combination of transcriptome and metabolomics methods. This was conducted to investigate the effects of a high-altitude environment on spermatogenesis and the maturation of Tibetan sheep. The results showed that compared to the low-altitude group, the high-altitude group had a smaller epididymal lumen, thicker epididymal wall, significantly decreased sperm survival rate, and significantly increased sperm deformation rate, but no difference in sperm motility and sperm respiratory intensity.

Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data.

Background: Polycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous females worldwide. Dysbiosis of gut microbiota has been linked to the occurrence of PCOS; however, research into the characteristics of gut microbiota in PCOS patients, especially those from different regions and with different testosterone level, remains limited. Additionally, it is still unclear whether gut microbiota helps to distinguish different PCOS subtypes.

Dietary resveratrol improves immunity and antioxidant defense in ewes by regulating the rumen microbiome and metabolome across different reproductive stages.

Introduction: Resveratrol (Res), a natural plant antitoxin polyphenol, is widely used in animal husbandry due to its antioxidant and anti-inflammatory properties, and current research has focused on humans, sows, and female mice. This study aimed to analyze the effects of dietary Res supplementation in ewes on antioxidant activity, immune responses, hormone levels, rumen microbiota and metabolites across various reproductive stages (estrus, pregnancy, and lactation).

Methods: Twenty-four healthy ewe lambs (Hu sheep, 2 months old) with a similar body weight (BW) (mean: 21.

Strong Metal-Support Interactions in Heterogeneous Oxygen Electrocatalysis.

Molecular oxygen redox electrocatalysis involves oxygen reduction and evolution as core reactions in various energy conversion and environmental technology fields. Strong metal-support interactions (SMSIs) based nanomaterials are regarded as desirable and state-of-the-art heterogeneous electrocatalysts due to their exceptional physicochemical properties. Over the past decades, considerable advancements in theory and experiment have been achieved in related studies, especially in modulating the electronic structure and geometrical configuration of SMSIs to enable activity, selectivity, and stability.

Research Progress and Emerging Directions in Stimulus Electro-Responsive Polymer Materials.

Stimulus electro-responsive polymer materials can reversibly change their physical or chemical properties under various external stimuli such as temperature, light, force, humidity, pH, and magnetic fields. This review introduces typical conventional stimulus electro-responsive polymer materials and extensively explores novel directions in the field, including multi-stimuli electro-responsive polymer materials and humidity electro-responsive polymer materials pioneered by our research group. Despite significant advancements in stimulus electro-responsive polymer materials, ongoing research focuses on enhancing their efficiency, lifespan, and production costs.

Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.

Introduction: RNA interference (RNAi) stands as a widely employed gene interference technology, with small interfering RNA (siRNA) emerging as a promising tool for cancer treatment. However, the inherent limitations of siRNA, such as easy degradation and low bioavailability, hamper its efficacy in cancer therapy. To address these challenges, this study focused on the development of a nanocarrier system (HLM-N@DOX/R) capable of delivering both siRNA and doxorubicin for the treatment of breast cancer.