Intraoperative ex-vivo epifluorescent diagnostics of stereotactic brain biopsies using EndoScell scanner: diagnostic accuracy study.

Brain biopsy is commonly employed for the histological diagnosis of complex intracranial diseases. To improve the positive diagnostic rate, the precision of intraoperative tissue sampling is critical. This study evaluated the accuracy of fluorescence imaging technology in rapidly distinguishing tumours from nontumour tissue during surgery, thus providing real-time feedback to surgeons and optimizing the surgical workflow.

Atypical Intestinal Behçet's Disease Complicated by Latent Tuberculosis Infection.

Background: When Behçet's disease is complicated with gastrointestinal ulcers, it is referred to as intestinal Behçet's disease (BD). Clinically uncommon, this condition can involve the entire gastrointestinal tract, often presenting diagnostic challenges in differentiation from Crohn's disease.

Methods: In this case, atypical BD was diagnosed through endoscopic examination, whereas latent tuberculosis infection (LBTI) was confirmed via T-SPOT and PPD tests.

Interfacial adsorption behavior of amine-functionalized MCM-41 for Mo(VI) capture from aqueous solution.

Given the environmental and ecological risks posed by wastewater bearing molybdenum, the characteristics and microscopic interactions of existing silica-based adsorbents have not been thoroughly investigated, highlighting the need to enhance the porosity and chemical interactions of these materials. Considering the effectiveness of amino groups in binding metal oxyanions, this study investigates the adsorption performance and mechanism of amino-functionalized MCM-41 for Mo(VI), with the goal of efficiently remediating Mo-contaminated wastewater. MCM-41 modified by amino group retains its original structure and mesoporous characteristics while featuring a positively charged surface and chemically bonded amino groups.

Improving Corrosion Resistance of Rare Earth Zirconates to Calcium-Magnesium-Alumina-Silicate Molten Salt Through High-Entropy Strategy.

The erosion caused by high-temperature calcium-magnesium-alumina-silicate (CMAS) has emerged as a critical impediment to the advancement of thermal barrier coating (TBC). In this study, a series of high-entropy rare earth zirconates, (LaSmDyErGd)(ZrCe)O ( = 0, 0.2, 0.

Thermal Shielding GdTaO-Based Thermal Barrier Ceramic with Ultralow NIR Transmittance.

Most thermal barrier coating materials exhibit transparent/semi-transparent properties at higher temperatures, causing the surface heat flow to directly heat the substrate with infrared radiation, which significantly reduces the thermal barrier effectiveness. Herein, composite ceramic materials composed of GdFeO diffusely dispersed within the GdTaO are produced. Specifically, the 0.

Near-Infrared-II-Activated Transition Metal(II)-Coordinated Ligand Radical Primes Robust Anticancer Immunity.

Photoactivatable metallodrugs combining tumor cell eradication and immune stimulation hold immense promise for targeted cancer therapy. However, limitations such as oxygen dependence, narrow visible light responsiveness, and poor immunogenicity hinder their efficacy in deep solid tumors with hypoxic and immunosuppressive microenvironments. Herein, we present a novel design strategy for transition metal(II)-coordinated ligand radicals exhibiting intense near-infrared-II (NIR-II) absorption, unique endoplasmic reticulum-targeting capability, and oxygen-independent photothermal performance, effectively addressing these constraints.

Characteristics of Pore Structure and the Evolution Process in Terrestrial Shale Reservoirs: A Case Study of the Shahejie Formation in Dongpu Depression, Bohai Bay Basin.

Microscopic pore characteristics of shale are very important for exploring the oil occurrence and content. However, previous studies on heterogeneous terrestrial shale are lacking. We choose the Shahejie formation (SF) of the Dongpu Depression in the Bohai Bay Basin as a case study.

Brainstem Cryptococcoma.

Cryptococcoma in central nervous system is a special form of cryptococcal infection that presents as occupying lesions in human brains. Usually, it happens in cerebral or cerebellar lobes. Brainstem cryptococcoma is extremely rare, as only a few cases were reported until now.

Differential proteomic profiles of exosomes in pediatric and adult adamantinomatous craniopharyngioma cyst fluid.

Background: Adamantinomatous craniopharyngiomas (ACPs), commonly seen in pediatrics and adults often present with large cystic cavities that can compress surrounding tissues, causing severe visual and endocrine symptoms. Complete resection of cystic ACP is challenging, frequently leading to postoperative recurrence. The composition of the cystic fluid is complex, and to date, there has been limited research focusing on exosomes within ACP cyst fluid.

Development of Biomaterials to Modulate the Function of Macrophages in Wound Healing.

Wound healing is a complex and precisely regulated process that encompasses multiple stages, including inflammation, anti-inflammation, and tissue repair. It involves various cells and signaling molecules, with macrophages demonstrating a significant degree of plasticity and playing a crucial regulatory role at different stages. In recent years, the use of biomaterials, which include both natural and synthetic polymers or macromolecules, has proliferated for the purpose of enhancing wound healing.

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer's disease.

Background: Anti-amyloid-β (Aβ) immunotherapy trials have revealed amyloid-related imaging abnormalities (ARIA) as the most prevalent and serious adverse events linked to pathological changes in cerebral vasculature. Recent studies underscore the critical involvement of perivascular macrophages and the infiltration of peripheral immune cells in regulating cerebrovascular damage. Specifically, Aβ antibodies engaged at cerebral amyloid angiopathy (CAA) deposits trigger perivascular macrophage activation and the upregulation of genes associated with vascular permeability.

Devising Biocompatible, NIR-Activated Helical Pyroptosis Agents via 𝛑-Twisting Strategy for Promoting Antitumor Immunity.

Specifically controlling cell pyroptosis is advantageous for oncotherapy as it allows simultaneous ablation of primary tumors and activation of immunogenicity of tumor environment. Herein, a facile and robust strategy is presented to construct efficient NIR-activated helical pyroptosis agents (PyroAs) with negligible dark cytotoxicity. It is demonstrated that the construction of four intramolecular B-X bonds (X = O or N) within the BODIPY chromophore enforces a significant twisting of its π-conjugation, yielding a variety of helical BD molecules with desired high photosensitivity and negligible dark toxicity.

Vision-Centric BEV Perception: A Survey.

In recent years, vision-centric Bird's Eye View (BEV) perception has garnered significant interest from both industry and academia due to its inherent advantages, such as providing an intuitive representation of the world and being conducive to data fusion. The rapid advancements in deep learning have led to the proposal of numerous methods for addressing vision-centric BEV perception challenges. However, there has been no recent survey encompassing this novel and burgeoning research field.

Electrical Responsive Coating with a Multilayered TiO-SnO-RuO Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration.

The bacterial infection and poor osseointegration of Ti implants could significantly compromise their applications in bone repair and replacement. Based on the carrier separation ability of the heterojunction and the redox reaction of pseudocapacitive metal oxides, we report an electrically responsive TiO-SnO-RuO coating with a multilayered heterostructure on a Ti implant. Owing to the band gap structure of the TiO-SnO-RuO coating, electron carriers are easily enriched at the coating surface, enabling a response to the endogenous electrical stimulation of the bone.

Surgical management of a foramen magnum tumor via a far-lateral approach using an oblique straight incision: a case series report and technique note.

Objective: To review our single-institution experience in the surgical management of foramen magnum tumors via a far-lateral approach using an oblique straight incision.

Methods: From October 2023 to January 2024, four cases of tumors in the foramen magnum area treated at the Capital Medical University-affiliated XuanWu hospital neurosurgery department were involved in this study. All cases were managed with a far-lateral approach using an oblique straight incision.

Effect of SiN Additive on Microstructure and Mechanical Properties of Ti(C,N)-Based Cermet Cutting Tools.

Development of high-performance cutting tool materials is one of the critical parameters enhancing the surface finishing of high-speed machined products. Ti(C,N)-based cermets reinforced with and without different contents of silicon nitride were designed and evaluated to satisfy the requirements. In fact, the effect of silicon nitride addition to Ti(C,N)-based cermet remains unclear.

A disease warranting attention from neurosurgeons: primary central nervous system post-transplant lymphoproliferative disorder.

Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare condition, posing diagnostic and treatment challenges, with histological biopsy essential for diagnosis. Standardized treatment protocols are lacking. This disease requires urgent attention due to the increasing number of organ transplant surgeries and the use of immunosuppressive agents.

Development and Characterization of Bio-Based Formaldehyde Free Sucrose-Based Adhesive for Fabrication of Plywood.

In order to solve the problem of excessive consumption of petrochemical resources and the harm of free formaldehyde release to human health, biomass raw materials, such as sucrose (S) and ammonium dihydrogen phosphate (ADP) can be chemically condensed in a simple route under acidic conditions to produce a formaldehyde free wood adhesive (S-ADP), characterized by good storage stability and water resistance, and higher wet shear strength with respect to petroleum based phenolic resin adhesive. The dry and boiling shear strength of the plywood based on S-ADP adhesive are as high as 1.05 MPa and 1.

Pursuing Impactful Quantitative Proteomics Using QC-Channels in Every Spectrum and Trend-Design in Experiment.

False changes discovered by quantitative proteomics reduce the trust of biologists in proteomics and limit the applications of proteomics to unlock biological mechanisms, which suppresses the application of proteomics techniques in the pharmaceutical industry more than it does in academic research. To remove false changes that arise during LC-MS/MS data acquisition, we evaluated the contributions of peptide abundance and number of unique peptides on reproducibility. Lower abundance and only one unique peptide have a higher risk of generating a higher coefficient of variation (CV), resulting in less accurate quantification.

Scalable Production of Highly Conductive 2D NbSe Monolayers with Superior Electromagnetic Interference Shielding Performance.

Thin, flexible, and electrically conductive films are in demand for electromagnetic interference (EMI) shielding. Two-dimensional NbSe monolayers have an electrical conductivity comparable to those of metals (10-10 S m) but are challenging for high-quality and scalable production. Here, we show that electrochemical exfoliation of flake NbSe powder produces monolayers on a large scale (tens of grams), at a high yield (>75%, monolayer), and with a large average lateral size (>20 μm).

Regulating microstructures of aerogels by controlling phase separation mechanism for improving specific surface area and energy harvesting.

Aerogels with 3D porous structures have been attracting increasing attention among functional materials due to their advantages of being lightweight and high specific surface area. Precise control of the porous structure of aerogel is essential to improve its performance. In this work, polylactic acid (PLA) aerogels with distinctly different microstructures were fabricated by precisely controlling the phase separation behavior of the ternary solution system.

Phase morphology, rheological behavior and mechanical properties of supertough biobased poly(lactic acid) reactive ternary blends.

Poly(lactic acid) (PLA) is one of the most promising bio-based polyester with great potential to replace for the petroleum-based polymers, which can significantly reduce greenhouse gas emissions. However, the inherent brittleness of PLA seriously restricts its broad applications. Herein, PLA/poly(ε-caprolactone) (PCL)/ethylene methyl acrylate-glycidyl methacrylate (EMA-GMA) ternary blends with different phase structures were prepared through reactive blending.