A method for the rapid detection of heavy metal mercury ions based on a novel mercury chelator N,N'-bis (2-mercaptoethyl) isophthalamide.

Mercury has caused severe harm to the environment and human health. A novel biological screen method was developed and identified a Hg chelator BDTH2. Both biological and chemical methods demonstrated BDTH2 displayed a high specificity and strong binding capacity for Hg.

Machine learning for predicting acute myocardial infarction in patients with sepsis.

Acute myocardial infarction (AMI) and sepsis are the leading causes of high mortality rates in intensive care units. While sepsis frequently affects the cardiovascular system, distinguishing between sepsis-induced cardiomyopathy and AMI remains challenging due to overlapping biomarkers. Misdiagnosis can hinder timely treatment and increase risk of complications.

Mechanisms of microbiota-gut-brain axis communication in anxiety disorders.

Anxiety disorders, prevalent mental health conditions, receive significant attention globally due to their intricate etiology and the suboptimal effectiveness of existing therapies. Research is increasingly recognizing that the genesis of anxiety involves not only neurochemical brain alterations but also changes in gut microbiota. The microbiota-gut-brain axis (MGBA), serving as a bidirectional communication pathway between the gut microbiota and the central nervous system (CNS), is at the forefront of novel approaches to deciphering the complex pathophysiology of anxiety disorders.

Latent profile analysis of anticipatory grief in family caregivers of patients with chronic heart failure and its influencing factors.

Background: Anticipatory grief has been shown to be highly prevalent among family caregivers of patients with advanced illness. However, there is less research on the anticipatory grief of family caregivers with chronic heart failure. Therefore, the purpose of this study was to explore the profile of anticipatory grief among family caregivers of patients with chronic heart failure and to analyze the influencing factors of different profiles.

Identification of chromosome ploidy and karyotype analysis of cherries ( Lindl.) in Guizhou.

The present study aimed to characterize the chromosome features of cherry ( Lindl.) germplasm in Guizhou Province, China, in order to facilitate the selection and breeding programs of this economically and ornamentally valuable species. The stem tip chromosome preparation technique was employed for ploidy identification and karyotype analysis, and the results were further validated by flow cytometry.

Synergistic Anticancer Strategy Targeting ECM Stiffness: Integration of Matrix Softening and Mechanical Signal Transduction Blockade in Primary Liver Cancers.

The development of primary liver cancer (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma [ICC]) is linked to its physical microenvironment, particularly extracellular matrix (ECM) stiffness. Potential anticancer strategies targeting ECM stiffness include prevention/reversal of the stiffening process and disruption of the response of cancer cells to mechanical signals from ECM. However, each strategy has limitations.

Co/CoO hetero-nanoparticles incorporated into lignin-derived carbon nanofibers as a self-supported bifunctional oxygen electrocatalyst for rechargeable Zn-air batteries.

The large-scale application of rechargeable Zn-air batteries (ZABs) necessitates the development of high-efficiency and cost-effective bifunctional electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, the density functional theory calculations were performed to reveal the charge redistribution induced by the Co/CoO heterojunction integrating with N-doped carbon, which could optimize the d-band center, thereby accelerating O transformed into OOH* in the ORR and the conversion of O* into OOH* in OER. Guided by theoretical calculations, Co/CoO hetero-nanoparticles-decorated lignin-derived N-doped porous carbon nanofibers (Co-LCFs-800) were synthesized to use as an advanced self-supported bifunctional oxygen electrocatalyst.

Negative Emotion Differentiation Promotes Cognitive Reappraisal: Evidence From Electroencephalogram Oscillations and Phase-Amplitude Coupling.

Cognitive reappraisal, an effective emotion regulation strategy, is influenced by various individual factors. Although previous studies have established a link between negative emotion differentiation (NED) and cognitive reappraisal, the underlying neural mechanisms remain largely unknown. Using electroencephalography, this study investigates the influence and neural basis of NED in cognitive reappraisal by integrating aspects of event-related potentials, neural oscillation rhythms, and cross-frequency coupling.

Association of inflammatory blood markers and pathological complete response in HER2-positive breast cancer: a retrospective single-center cohort study.

Introduction: The association between inflammatory blood markers (IBMs) (monocyte-to-lymphocyte ratio [MLR], neutrophil-to-lymphocyte ratio [NLR], and platelet-to-lymphocyte ratio [PLR]) and breast cancer has been extensively studied. However, the predictive role of IBMs in the neoadjuvant response of human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains unclear.

Methods: This study included 744 patients with HER2 positive breast cancer treated with neoadjuvant therapy.

Decelerating and Accelerating Sulfur Reduction Reaction via P-O-InO Enables High-Performance Li-S Batteries.

The sluggish sulfur reduction reaction (SRR) kinetics of lithium-sulfur (Li-S) batteries seriously limits the development of Li-S batteries. The initial reduction of solid (S) to liquid (soluble LiS (4≤n≤8)) is relatively easy due to the low activation energy, whereas the subsequent conversion of liquid (soluble LiS) to solid (insoluble LiS/LiS) has much higher activation energy, which leads to the accumulation of LiS and exacerbates the shuttle effect of LiS. Therefore, establishing one selective catalyst that decelerates the previous solid-liquid reaction and accelerates the subsequent liquid-solid reaction is essential for rational tailoring of the SRR for improved performance of Li-S batteries, but it represents a daunting challenge.

SPIRRIG is required for BRICK1 stability and salt stress induced root hair developmental plasticity in Arabidopsis.

Developmental plasticity is critical for plants to adapt to constantly changing environments. Plant root hairs display dramatic plasticity under different environments and therefore play crucial roles in defense against environmental stressors. Here, we report the isolation of an Arabidopsis mutant, salinity over-sensitive mutant 1-1 (som1-1), also exhibiting root hair developmental defects.

Controlled enzyme cargo loading in engineered bacterial microcompartment shells.

Bacterial microcompartments (BMCs) are nanometer-scale organelles with a protein-based shell that serve to co-localize and encapsulate metabolic enzymes. They may provide a range of benefits to improve pathway catalysis, including substrate channeling and selective permeability. Several groups are working toward using BMC shells as a platform for enhancing engineered metabolic pathways.

Dynamic distribution of tetracycline and its degradation products in different organs of the geophagous earthworm Metaphire guillelmi.

Tetracycline (TC) residues in the environment are harmful to plants and animals; earthworms play an important role in detoxicating tetracycline in the soil. However, the response of different systems of the geophagous earthworm to TC and its degradation products is still not understood well. To understand this problem, Metaphire guillelmi were exposed to the soil contaminated by 100 mg kg tetracycline for 21 days.

The Rhizome of Atractylodes macrocephala Koidz.: A Comprehensive Review on the Traditional Uses, Phytochemistry and Pharmacology.

Atractylodes macrocephala Koidz. (A. macrocephala) is a perennial herb of the genus Atractylodes.

CXCL13/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia.

Background: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder defined by a diminished platelet count. ITP pathogenesis involves intricate changes to both cellular and humoral immunity. The pivotal roles of follicular helper T (TFH) cells in the maturations of B cells and the production of antibodies are well-established.

Evaluating the performance of carbon dioxide and methane observations from carbon-monitoring satellite products over China.

As the primary greenhouse gases contributing to climate change, carbon dioxide (CO₂) and methane (CH) play a critical role in the Earth's radiative balance and temperature regulation. Continuous and accurate satellite monitoring of CO₂ and CH₄ is essential for developing effective policies and strategies to mitigate their impacts. This study utilizes ground-based Fourier-transform infrared measurements from the Total Carbon Column Observing Network (TCCON) to evaluate the performance of current mainstream carbon-monitoring satellites over China, the world's largest carbon emitter.

Kaempferol promotes osteogenic differentiation in bone marrow mesenchymal stem cells by inhibiting CAV-1.

Objective: Our study focused on the effects and molecular mechanisms of kaempferol, a major active component of Eucommia ulmoides Oliver (EUO), on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).

Methods: Target molecules for EUO, osteoarthritis, and osteogenic differentiation were identified through network pharmacology analysis. BMSCs were isolated and treated with various concentrations of kaempferol.

Identification of sequence polymorphism in the D-loop region of mitochondrial DNA as a risk factor for breast cancer.

Mitochondrial DNA (mtDNA) variations affect the efficiency of the electron transport chain and production of reactive oxygen species, contributing to carcinogenesis. The D-loop region of mtDNA has emerged as a variation hotspot region in human neoplasia; however, the potential contribution of these variations in breast cancer risk prediction remains unknown. We investigated the relationship between germline single nucleotide polymorphisms (SNPs) in the entire D-loop region and breast cancer risk in Chinese women.

Application of PROTACs in Target Identification and Target Validation.

PROTAC, as a novel therapeutic drug model, has received widespread attention from the academic and pharmaceutical industries. At the same time, PROTAC technology has led many researchers to focus on developing chemical biology tool properties due to its unique operating mechanism and protein dynamic regulatory properties. In recent years, the rapid development of PROTAC technology has gradually made it an essential tool for target identification and target validation.