Acid and Glutathione Dual-Responsive, Injectable and Self-Healing Hydrogels for Controlled Drug Delivery.

Considering the complexity of physiological microenvironments and the risks of surgical infection, there still remains critical demand to develop a hydrogel as a drug release platform with multifunctional properties, including good neutral stability and sensitive multiple stimuli-responsive behaviors, as well as injectable and self-healing properties. Herein, we present a facile preparation of injectable, self-healing hydrogels with acid and glutathione (GSH) dual-responsiveness for controlled drug delivery. Initially, the anticancer drug camptothecin (CPT) was premodified with disulfide bonds and attached to poly(ethylenimine) (PEI) via the Schiff base reaction, resulting in PEI-CPT.

Characterizing the external exposome using passive samplers-comparative assessment of chemical exposures using different wearable form factors.

Background: Organic contaminants are released into the air from building materials/furnishings, personal care, and household products. Wearable passive samplers have emerged as tools to characterize personal chemical exposures. The optimal placement of these samplers on an individual to best capture airborne exposures has yet to be evaluated.

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment.

Human exposure to per- and polyfluoroalkyl substances (PFASs) has gained worldwide attention due to their widespread presence in the environment and adverse health effects, but the exposure assessment in the elderly is still lacking. This study aimed to assess exposures to 3 emerging PFASs (chlorinated polyfluoroalkyl ether sulfonic acids, Cl-PFESAs) and 15 legacy PFASs. The temporal variability of internal exposures and intake amounts of these PFASs were evaluated among a population of 76 healthy elderly adults (age: 60-69) in Jinan, China over 5 consecutive months.

Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study.

Children in low- and middle-income countries are often exposed to higher levels of chemicals and are more vulnerable to the health effects of air pollution. Little is known about the diversity, toxicity, and dynamics of airborne chemical exposures at the molecular level. We developed a workflow employing state-of-the-art wearable passive sampling technology coupled with high-resolution mass spectrometry to comprehensively measure 147 children's personal exposures to airborne chemicals in Limpopo, South Africa, as part of the Venda Health Examination of Mothers, Babies, and Their Environment (VHEMBE).

Performance and mechanism analysis of gel immobilized anammox bacteria in treating different proportions of domestic wastewater: a valid alternative to granular sludge.

The treatment performance of anaerobic ammonia oxidation (anammox) immobilized filler on different proportions of domestic wastewater was evaluated. The results showed that, in comparison to synthetic wastewater, 50% domestic wastewater promoted the anammox reaction of immobilized filler, while 100% domestic wastewater had no significant effect on the anammox activity of immobilized filler but the total nitrogen removal efficiency (TNRE) was improved through enhanced denitrification. The TNRE of the immobilized filler was 82.

Prevalence and Implications of Per- and Polyfluoroalkyl Substances (PFAS) in Settled Dust.

Purpose Of Review: Per- and polyfluoroalkyl substances (PFAS) are a family of more than 7,000 fluorinated compounds. The carbon-fluorine bond of PFAS provides desirable hydrophobic and oleophobic properties and stability that has led to widespread usage in consumer products and industrial applications. The strength of the carbon-fluorine bond also prevents appreciable degradation once released into the environment.

Wearing time and respiratory volume affect the filtration efficiency of masks against aerosols at different sizes.

Face masks are critical in preventing the spread of respiratory infections including coronavirus disease 2019 (COVID-19). Different types of masks have distinct filtration efficiencies (FEs) with differential costs and supplies. Here we reported the impact of breathing volume and wearing time on the inward and outward FEs of four different mask types (N95, surgical, single-use, and cloth masks) against various sizes of aerosols.

Head, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed.

Chemical exposures are a major risk factor for many diseases. Comprehensive characterization of personal exposures is necessary to highlight chemicals of concern and factors that influence these chemical exposure dynamics. For this purpose, wearable passive samplers can be applied to assess longitudinal personal exposures to airborne contaminants.

Denitrification performance and bacterial flora analysis of immobilized denitrification filler in industrial wastewater.

The study aimed at evaluating the nitrogen removal performance of the immobilized denitrification filler, and the influence of shock loading on the high-rate denitrification process. A pilot scale reactor was operated for treatment of aniline production wastewater. The nitrogen removal activity significantly increased in the continuous feed experiments, reaching 5.

[Research on Denitrification Performance of Enhanced Secondary Effluent by Embedded Denitrification Filler and Pilot Application].

The use of an embedded broad-spectrum high-efficiency denitrification filler to treat secondary effluent from municipal wastewater treatment plants can effectively reduce total nitrogen (TN) concentration of the effluent. This study consists of two parts. The D1 stage studies the adaptability of the secondary effluent based on the embedded denitrification, removal effect of total nitrogen, stable working conditions, and backwashing conditions; In the D2 stage, the change in the nitrogen removal performance of the filler under the condition of a year-long stable operation was studied.

Analysis of rapid culture of high-efficiency nitrifying bacteria and immobilized filler application for the treatment of municipal wastewater.

Activated sludge from the A/O process in a wastewater treatment plant (WWTP) was used as the seed sludge for enrichment to achieve faster growth of nitrifying bacteria and higher nitrification efficiency of the filler made by nitrifying bacteria. The bacterial community was enriched in a self-circulating bacteria culture tank by a continuous ammonia feeding mode. The study found that the nitrifying bacteria community was enriched in 38 days with the ammonia oxidation rate of approximately 275.