Asymmetric Coordination Engineering of Tin Single-Atom Catalysts Toward CO Electroreduction: the Crucial Role of Charge Capacity in Selectivity.

Electrochemical reduction of CO is an efficient strategy for CO utilization under mild conditions. Tin (Sn) single-atom catalysts (SACs) are promising candidates due to their controllable CO/formate generation via asymmetric coordination engineering. Nevertheless, the factors that govern the selectivity remain unclear.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Dinitrogen Activation and Conversion by Actinide Complexes.

The efficient activation and conversion of dinitrogen (N) represent a significant challenge in sustainable chemistry, offering potential pathways for synthesizing valuable nitrogen-containing compounds while reducing the environmental impact of traditional nitrogen fixation processes. While transition metal catalysts have been extensively studied for this purpose, actinide complexes have been less explored but have recently emerged as promising candidates due to their unique electronic properties and reactivity. This Perspective systematically examines the recent advances in N activation and conversion mediated by actinide complexes, with a particular focus on their synthesis, mechanistic insights, and catalytic capabilities.

Preparation of quaternary ammonium lignosulfonate modified UV resistant polyurethane and its application in leather dyeing.

Applying cationic waterborne polyurethane (CWPU) in the leather color-fixing process can improve the dyeing rate and enhance color fastness. However, under prolonged exposure to sunlight, CWPU will age and degrade and the leather will fade in color, become stiff and crack easily. In this study, an Ultraviolet absorber was introduced into cationic waterborne polyurethane (UVCWPU) and quaternary ammonium Lignosulfonate (QLS) was prepared by quaternization.

PEAR1, PON1, CYP2C19, CYP1A2 and F2R Polymorphisms are Associated with MACE in Clopidogrel-Treated Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

Objective: The objective of this study was to evaluate the impact of clopidogrel-related gene polymorphisms on the occurrence of recurrent thrombotic events and cardiovascular death in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI).

Methods: We conducted genotype testing for 26 specific loci mapped to 18 clopidogrel-associated genes in ACS patients who had undergone PCI and were receiving dual antiplatelet therapy only involving clopidogrel. We documented major adverse cardiovascular events (MACE) and clinical endpoints, analyzing the effect of genetic polymorphisms on treatment outcomes.

SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.

In recent years, targeting mitochondrial apoptosis has emerged as a promising therapeutic strategy for Acute Myeloid Leukemia (AML). The SLC25 family of mitochondrial carriers plays a critical role in maintaining mitochondrial function and regulating apoptosis. However, the role of SLC25A21, an oxodicarboxylate carrier, in AML progression and its potential as a prognostic biomarker remain underexplored.

Quantitative and rapid lateral flow immunoassay for cardiac troponin I using dendritic mesoporous silica nanoparticles and gold nanoparticles.

Acute myocardial infarction (AMI) is considered to be one of the predominant causes of human death; therefore, a rapid and accurate diagnostic method for AMI is urgently required. In this work, a highly sensitive lateral flow immunoassay (LFIA) platform was designed and fabricated for the quantitative determination of cardiac troponin I (cTnI) using a scanner, a smartphone and a colloidal gold immunoassay analyzer. To overcome the limitation of low sensitivity of traditional colloidal gold-based LFIA, three-dimensionally assembled gold nanoparticles (AuNPs) within a dendritic mesoporous silica nanoparticle (DMSN) scaffold were fabricated as signal labels.

Thermal degradation behaviours, VOCs emission characteristics, and environmental impacts during pyrolysis recycling of waste enamelled wires.

Waste enamelled wires represent a significant secondary copper resource, often processed through pyrolysis for material recovery. However, the release of VOCs during pyrolysis poses environmental challenges. This study investigated the thermal degradation behaviour and VOCs emission characteristics of waste enamelled wires during pyrolysis.

Role of ENO1 and its targeted therapy in tumors.

ENO1, also called 2-phospho-D-glycerate hydrolase in cellular glycolysis, is an enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate and plays an important role in the Warburg effect. In various tumors, ENO1 overexpression correlates with poor prognosis. ENO1 is a multifunctional oncoprotein that, when located on the cell surface, acts as a "moonlighting protein" to promote tumor invasion and metastasis.

Anti-tumor mechanism of artesunate.

Artesunate (ART) is a classic antimalarial drug with high efficiency, low toxicity and tolerance. It has been shown to be safe and has good anti-tumor effect. Existing clinical studies have shown that the anti-tumor mechanisms of ART mainly include inducing apoptosis and autophagy of tumor cells, affecting tumor microenvironment, regulating immune response, overcoming drug resistance, as well as inhibiting tumor cell proliferation, migration, invasion, and angiogenesis.

Flg22-facilitated PGPR colonization in root tips and control of root rot.

Plant root border cells (RBCs) prevent the colonization of plant growth-promoting rhizobacteria (PGPR) at the root tip, rendering the PGPR unable to effectively control pathogens infecting the root tip. In this study, we engineered four strains of Pseudomonas sp. UW4, a typical PGPR strain, each carrying an enhanced green fluorescent protein (EGFP)-expressing plasmid.

Spinosin improves anxiety disorders in mice with chronic restraint stress via the ERK1/2-CREB-BDNF pathway.

Anxiety disorders, a prevalent mental health condition often stemming from chronic stress, are characterized by uncontrollable emotional responses, heightened psychological stress, and cognitive impairment. Ziziphi Spinosae Semen, a traditional Chinese medicine (TCM), is widely used for its calming effects. Among its flavonoid components, spinosin serves as a primary bioactive compound, playing a significant role in treating psychiatric disorders.

Charge-transfer dipole low-frequency vibronic excitation at single-molecular scale.

Scanning tunneling microscopy (STM) vibronic spectroscopy, which has provided submolecular insights into electron-vibration (vibronic) coupling, faces challenges when probing the pivotal low-frequency vibronic excitations. Because of eigenstate broadening on solid substrates, resolving low-frequency vibronic states demands strong decoupling. This work designs a type II band alignment in STM junction to achieve effective charge-transfer state decoupling.

A machine learning-assisted study of the formation of oxygen vacancies in anatase titanium dioxide.

Defect engineering of semiconductor photocatalysts is critical in reducing the reaction barriers. The generation of surface oxygen vacancies allows substantial tuning of the electronic structure of anatase titanium dioxide (TiO), but disclosing the vacancy formation at the atomic level remains complex or time-consuming. Herein, we combine density functional theory calculations with machine learning to identify the main factors affecting the formation of oxygen defects and accelerate the prediction of vacancy formation.

The Ultramorphology and Sexual Dimorphism of Antennae and Sensilla in the Pale Grass Blue, (Lepidoptera: Lycaenidae).

The pale grass blue, , is a small lycaenid butterfly widely distributed across Asia. Due to its exclusively diurnal lifestyle and conspicuous sexual dimorphism in wing coloration, vision has traditionally been regarded as the primary sensory system driving various behaviors. However, non-visual sensory systems related to sex-specific behavioral responses, such as antennae, have received far less attention.

Axial Coordination Engineering on Fe-N-C Materials for Oxygen Reduction: Insights from Theory.

Axial coordination engineering has emerged as an effective strategy to regulate the catalytic performance of metal-N-C materials for oxygen reduction reaction (ORR). However, the ORR mechanism and activity changes of their active centers modified by axial ligands are still unclear. Here, a comprehensive investigation of the ORR on a series of FeN-L moieties (L stands for an axial ligand) is performed using advanced density functional theory (DFT) calculations.

Synthesis and Photocatalytic sp C-H Bond Functionalization of Salen-Ligand-Supported Uranyl(VI) Complexes.

Recent years have seen increasing interest in uranyl(VI) photocatalysis. In this study, uranyl complexes were successfully synthesized from ligands - and UO(NO)·6HO under reflux conditions, yielding products - with yields ranging from 30% to 50%. The complexes were thoroughly characterized using NMR spectroscopy, single-crystal X-ray diffraction, and elemental analysis.

Promotion of aromatic amino acids of extracellular polymeric substance targeted transformation via sulfite mediated iron redox cycling in sludge solid-liquid separation.

Highly hydrophilic extracellular polymeric substance (EPS) with gel-like structure seriously plagues the development of sludge deep dewatering. Oxysulfur radicals-based oxidation driven by iron-bearing mineral proposes a promising strategy for effective EPS decomposition. However, the transformation and involved interaction mechanisms of aromatic proteins are still controversial due to the complex EPS structure.

Dihydromyricetin suppresses endothelial NLRP3 inflammasome activation and attenuates atherogenesis by promoting mitophagy.

Background: NOD-like receptor protein 3 (NLRP3) inflammasome activation is indispensable for atherogenesis. Mitophagy has emerged as a potential strategy to counteract NLRP3 inflammasome activation triggered by impaired mitochondria. Our previous research has indicated that dihydromyricetin, a natural flavonoid, can mitigate NLRP3-mediated endothelial inflammation, suggesting its potential to treat atherosclerosis.

Mo Migration-Induced Crystalline to Amorphous Conversion and Formation of RuMo/NiMoO Heterogeneous Nanoarray for Hydrazine-Assisted Water Splitting at Large Current Density.

Manipulating the atomic structure of the catalyst and tailoring the dissociative water-hydrogen bonding network at the catalyst-electrolyte interface is essential for propelling alkaline hydrogen evolution reaction (HER) and hydrazine oxidation reaction (HzOR), but remains a great challenge. Herein, we constructed an advanced a-RuMo/NiMoO/NF heterogeneous electrocatalyst with amorphous RuMo alloy nanoclusters anchored to amorphous NiMoO skeletons on Ni foam by a heteroatom implantation strategy. Theoretical calculations and in situ Raman tests show that the amorphous and alloying structure of a-RuMo/NiMoO/NF not only induces the directional evolution of interfacial HO, but also lowers the d-band center (from -0.

The fate of antibiotics and antibiotic resistance genes in Large-Scale chicken farm Environments: Preliminary view of the performance of National veterinary Antimicrobial use reduction Action in Guangdong, China.

In 2018, China implemented the Veterinary Antimicrobial Use Reduction Action to curb the rapid development of antibiotic resistance (AR). However, the AR-related pollutions in animal farms after the reduction policy has been poorly investigated. Here, we performed a comprehensive investigation combining UPLC-MS/MS, metagenomic, and bacterial genomic analyses in eight representative large-scale chicken farms in Guangdong, China.

Spatial dynamics of transport accessibility and regional efficiency in the Yangtze River Delta Urban Agglomeration.

Transport accessibility is crucial for defining urban clusters and evaluating a region's centrality and connectivity. To foster equitable growth in urban conglomerates, it is crucial to understand the relationship between transport accessibility and regional development. This study introduces the concept of 'regional efficiency'-the effectiveness of converting regional inputs into outputs-determined via the super-efficiency Data Envelopment Analysis methodology, to assess the progression of regional development.

[Characteristics and Source Analysis of VOCs Pollution During Emergency Response in Tianjin].

To elucidate the characteristics of VOCs chemical components during heavy pollution episodes, hourly online VOCs data derived from 11 heavy pollution events in Tianjin from 2019 to 2020 were employed. The positive matrix factorization （PMF） and conditional bivariate probability function （CBPF） were employed to analyze the sources of VOCs during heavy pollution episodes. The results indicated that the average VOCs volume fraction during these episodes was recorded at 35.

GMMID: genetically modified mice information database.

Genetically engineered mouse models (GEMMs) are vital for elucidating gene function and disease mechanisms. An overwhelming number of GEMM lines have been generated, but endeavors to collect and organize the information of these GEMMs are seriously lagging behind. Only a few databases are developed for the information of current GEMMs, and these databases lack biological descriptions of allele compositions, which poses a challenge for nonexperts in mouse genetics to interpret the genetic information of these mice.