Publications by authors named "YaCong Xie"
Article Synopsis
- Hebbian synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), is key for learning and memory, with SHP2 protein playing a role in AMPA receptor movement during LTP.
- The study discovered that SHP2's phosphorylation at Y542 decreases post-LTD induction in hippocampal cultures and slices, and this effect is blocked by an NMDA receptor antagonist.
- A specific SHP2 mutation linked to Noonan syndrome hinders the removal of AMPA receptors during LTD, highlighting SHP2's regulatory role and its relevance to the mechanisms of learning and memory.
Aim: RhoA/Rho kinase pathway is essential for regulating cytoskeletal structure. Although its effect on normal neurite outgrowth has been demonstrated, the role of this pathway in seizure-induced neurite injury has not been revealed. The research examined the phosphorylation level of RhoA/Rho kinase signaling pathway and to clarify the effect of fasudil on RhoA/Rho kinase signaling pathway and neurite outgrowth in kainic acid (KA)-treated Neuro-2A cells and hippocampal neurons.
View Article and Find Full Text PDFComplete chloroplast genome of , an endemic fern in China.
Mitochondrial DNA B Resour
September 2019
is the only aquatic pteridophyte in China with high research value of phylogeny. It is in endangered status. A conservation strategy is therefore imperative for this endangered pteridophyte.
View Article and Find Full Text PDF[Rapamycin improves learning and memory ability in ICR mice with pilocarpine-induced temporal lobe epilepsy].
Zhejiang Da Xue Xue Bao Yi Xue Ban
November 2013
Objective: To investigate the effect of rapamycin, an mTOR inhibitor, on learning and memory ability of mice with pilocarpine (PILO)-induced seizure.
Methods: One hundred and sixty male adult ICR mice were randomly grouped as vehicle control (n=20), rapamycin control (n=20), PILO model (n=40), rapamycin pre-treatment (n=40) and rapamycin post-treatment (n=40). PILO model and rapamycin treatment groups were injected with PILO to induce temporal lobe seizure.