[Relationship between six single nucleotide polymorphisms of angiotensinogen gene and essential hypertension].

Objective: To evaluate the relationship of six single nucleotide polymorphisms(SNPs) and their haplotypes of angiotensinogen(AGT) gene to essential hypertension(EH) in Chinese Han population.

Methods: The genotypes in 185 patients with EH and 185 healthy controls were determined by the method of ABI PRISM SNaPshot Multiplex Kit using six AGT gene polymorphisms at position -217(G/A), -152(G/A), -20(A/C) and -6(G/A) in the promoter region and T174M, M235T in exon 2.

Results: The distribution of AGT genotypes and alleles frequencies showed no significant difference between the group of EH and group of controls (P>0.