Publications by authors named "Ya-tong Zhang"
Although organic-inorganic hybrid Mn halides have advanced significantly, achieving high stability and narrow-band emission remains enormously challenging owing to the weak ionic nature and soft crystal lattice of the halide structure. To address these issues, we proposed a cationic engineering strategy of long-range cation π···π stacking and C-H···π interactions to simultaneously improve the crystal structural stability and rigidity. Herein, two organic zero-dimensional (0D) manganese halide hybrids of (BACQ)MnX [BACQ = 4-(butylamino)-7-chloroquinolin-1-ium; X = Cl and Br] were synthesized.
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- The study developed a pharmacokinetic (PK) and pharmacodynamic (PD) model using data from healthy Chinese individuals and non-valvular atrial fibrillation (NVAF) patients to understand bleeding risks and drug effects.* -
- The model utilized extensive data including dabigatran concentration and various coagulation tests from 285 participants, revealing strong correlations between PD biomarkers and bleeding events over a year.* -
- Key findings indicated that fixed dabigatran doses could be safely administered to NVAF patients without adjusting for certain factors, while higher exposure levels correlated with increased bleeding risk, necessitating further randomized studies for efficacy in this population.*
Aims: Ciclosporin (CsA), which is widely used in autoimmune disease and transplantation, has a narrow therapeutic index. It also shows considerable interindividual variability in its pharmacokinetics, which may be attributable to polymorphisms of the multidrug efflux pump P-glycoprotein, encoded by MDR-1. The aim was to determine the role of genetic polymorphisms in MDR-1 with respect to interindividual variability of CsA blood concentrations in myasthenia gravis (MG) patients.
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