Publications by authors named "Ya-ping Chen"

Radiotherapy is a primary treatment method for lung cancer, and radiation-induced lung injury has been widely studied. However, the lung and intestines are closely related, and patients receiving lung radiotherapy often experience gastrointestinal reactions. Huanglian Decoction has proven effective in treating intestinal diseases, but its role in radiation-induced intestinal injury in lung cancer has not yet been demonstrated.

View Article and Find Full Text PDF

Three new species of (Lamiaceae) from China are described and illustrated, based on both morphological evidence and our recent phylogenomic studies of the genus. , a herbaceous new species known only from the Fanjing Mountain, is shown to be sister to , but they can be easily distinguished by leaf and inflorescence indumentum, calyx teeth shape and corolla tube morphology. , a herbaceous new species collected from the Hengduan Mountains in southwest China, represents a distinct lineage within the genus.

View Article and Find Full Text PDF

, with 150-170 species, is the second largest and perhaps most taxonomically challenging genus within the subfamily Lamioideae (Lamiaceae). With about 60 species, China is one of three major biodiversity centers of . Although some species from China have been included in previous molecular phylogenetic studies, a robust and broad phylogeny of this lineage has yet to be completed.

View Article and Find Full Text PDF

, a new species in Bomi County, Xizang, China, was described and illustrated. In addition, , previously only known from Nepal and Bhutan, is newly recorded from Dingri County, Xizang, China. The phylogenetic placement of both species within the genus was analysed using nine plastid DNA markers (, , , , , , , , ).

View Article and Find Full Text PDF
Article Synopsis
  • Burkitt lymphoma is marked by high cell turnover and lipid droplets, while diffuse large B-cell lymphoma (DLBCL) also contains lipid droplets but with less clarity; this study confirms LD presence in DLBCL using various staining techniques.
  • A cohort study of 52 DLBCL patients revealed that the presence of lipid droplets correlates with poorer prognosis and higher International Prognostic Index (IPI) scores, signifying a worse outcome for patients.
  • Additional findings from whole exome and transcriptome analyses indicate that LD-positive DLBCL might share genetic features with specific subtypes and suggest that lipogenic genes could serve as potential therapeutic targets.
View Article and Find Full Text PDF
Article Synopsis
  • Two new species from the Lamiaceae family have been identified in Guangdong Province, China, and are described in this study.
  • These species belong to the subgenus P.ser.Subcoriaceae and show a close relationship through molecular analyses using ETS and ITS genes.
  • The IUCN assessment classified one species as Endangered (EN) and the other as Data Deficient (DD).
View Article and Find Full Text PDF

Purpose: To analyze the composition of abnormal hemoglobin and the relationship between genotype and phenotype by screening abnormal hemoglobin in a subpopulation of Guizhou, China.

Patients And Methods: Routine blood evaluation, capillary electrophoresis of hemoglobin, and mutation of α - and β - thalassemia genes were evaluated in 19,976 individuals for thalassemia screening in Guizhou. Sanger sequencing of HBA1, HBA2 and HBB genes was performed in samples with abnormal bands or unexplained increases of normal bands.

View Article and Find Full Text PDF

Aurora kinase inhibitors, such as alisertib, can destabilize MYC-family oncoproteins and have demonstrated compelling antitumor efficacy. In this study, we report 6K465, a novel pyrimidine-based Aurora A inhibitor, that reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib. In an analysis of the antiproliferative effect of 6K465, the sensitivities of small cell lung cancer (SCLC) and breast cancer cell lines to 6K465 were strongly associated with the protein levels of c-MYC and/or N-MYC.

View Article and Find Full Text PDF

is one of the largest genera of Lamiaceae with approximately 150-170 species distributed mainly in Eurasia. In this study, we describe and illustrate a new species, , which was previously misidentified as , from Yunnan Province, southwest China. Molecular phylogenetic analyses revealed that is found within a clade in which most species lack basal leaves.

View Article and Find Full Text PDF
Article Synopsis
  • - A new species has been identified and described from western Hunan, China, and is illustrated for clarity.
  • - Molecular phylogenetic analysis using three nuclear ribosomal DNA loci shows this new species as a sister group within its clade.
  • - The new species can be differentiated from another species by distinct features in lamina, corolla, and nutlet morphology, and a key for identifying all Stachydeae species in China is included.
View Article and Find Full Text PDF

Background: In our previous study, we provided evidence that Astragalus mongholicus Bunge(AM) and its extracts possess a protective capability against radiation-induced damage, potentially mediated through the reduction of reactive oxygen species (ROS) and nitric oxide (NO). However, we were pleasantly surprised to discover during our experimentation that AM not only offers protection against radiation damage but also exhibits a radiation sensitization effect. This effect may be attributed to a specific small molecule present in AM known as ononin.

View Article and Find Full Text PDF

BLS-type diffuse large B-cell lymphoma (DLBCL) denotes an uncommon, aggressive variant of DLBCL presenting initially in bone marrow, liver and spleen without lymphadenopathy or mass lesion. Patients with BLS-type DLBCL present frequently with haemophagocytic syndrome which often leads to early patient demise. Programmed death ligand 1 (PD-L1) plays a negative regulatory role on effector T cells and is an important target of immunotherapy.

View Article and Find Full Text PDF

Background: About 15-60% of individuals with ankle sprains may develop functional ankle instability (FAI), which is characterised by ankle pain, decreased muscle strength, limited range of motion, and impaired balance, causing a decline in social activity and quality of life. However, the relationship between those characters is still unclear. This study aimed to investigate whether a relationship existed between ankle pain, active range of motion (AROM), strength and balance and if ankle pain, AROM and strength can predict balance in individuals with FAI.

View Article and Find Full Text PDF

Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease, which is characterized by inflammation, with many symptoms including diarrhea, abdominal pain, bloody stool, and weight loss. It is difficult to completely cure and promising therapeutic drug candidates are urgently needed. Citropten, a coumarin-like compound found in traditional Chinese medicine such as Finger Citron Fruit, notopterygium root and citrus peel, has been shown to inhibit the proliferation of tumor cells, protect against depression and suppress the production of inflammatory mediators.

View Article and Find Full Text PDF

A 6-month-old female infant presented with unexplained hemolytic anemia, showing no abnormalities by capillary electrophoresis and genetic testing for α- and β-thalassemia mutations that are commonly seen in the Chinese population. A rare Hb Mizuho: [: c.206T > C β 68(E12) Leu- Pro] variant was identified by next-generation sequencing (NGS) and verified by Sanger sequencing.

View Article and Find Full Text PDF

The most prominent acoustic features in speech are intensity modulations, represented by the amplitude envelope of speech. Synchronization of neural activity with these modulations supports speech comprehension. As the acoustic modulation of speech is related to the production of syllables, investigations of neural speech tracking commonly do not distinguish between lower-level acoustic (envelope modulation) and higher-level linguistic (syllable rate) information.

View Article and Find Full Text PDF

The efficacy of Bruton tyrosine kinase inhibitors (BTKi) remains suboptimal in chronic lymphocytic leukemia (CLL) treatment. A systematic review and meta-analysis were conducted to compare the outcomes of combining anti-CD20 monoclonal antibodies (mAb) with BTKi therapy versus BTKi monotherapy for patients with CLL. We searched for relevant studies in the Pubmed, Medline, Embase, and Cochrane databases until December 2022.

View Article and Find Full Text PDF

(Lamiaceae), a new species from the limestone area in northern Guangdong Province, China, is described and illustrated. Phylogenetic analyses, based on two nuclear DNA regions (ITS and ETS) and three plastid DNA regions (, and ), suggest that represents a distinct species in . Morphologically, is similar to P.

View Article and Find Full Text PDF

As an alternative strategy for cancer treatment, the combination of cancer nanomedicine and immunotherapy is promising with regard to efficacy and safety; however, precise modulation of the activation of antitumor immunity remains challenging. Therefore, the aim of the present study was to describe an intelligent nanocomposite polymer immunomodulator, drug-free polypyrrole-polyethyleneimine nanozyme (PPY-PEI NZ), which responds to the B-cell lymphoma tumor microenvironment, for precision cancer immunotherapy. Earlier engulfment of PPY-PEI NZs in an endocytosis-dependent manner resulted in rapid binding in four different types of B-cell lymphoma cells.

View Article and Find Full Text PDF

The indumentum of nutlets is shown to be of phylogenetic importance in previous molecular phylogenetic studies of , a genus of Lamiaceae with approximately 30 species distributed mainly in southern China and Southeast Asia. Nearly half the species of are known from limestone areas. In this study, we described and illustrated a new species, , from the karst mountain forests in Guangxi Zhuang Autonomous Region, China.

View Article and Find Full Text PDF