Publications by authors named "Ya-nan Yin"
Background: Amyloid precursor-like protein 1 (APLP1) is involved in pathological α-synuclein transmission, but its role in Parkinson's disease (PD) progression has not been explored.
Objective: This study investigates APLP1 as a potential predictor for motor and cognitive deterioration in PD.
Methods: Plasma APLP1 levels were measured in PD patients from the Huashan Hospital for Parkinson's Disease (HSPD) and Parkinson's Disease Progression Markers Initiative (PPMI) cohorts.
Arthropod melanization is a crucial defense mechanism mediated by a complex cascade of CLIP domain serine proteases (CLIPs). In this study, it was confirmed that microRNA-11903a (miR-11903a) targets Aedes-CLIPB9 (AeCLIPB9) by bioinformatics prediction and dual-luciferase reporter assays. Following intrathoracic injection of miR-11903a agomir and antagomir, Real-time quantitative polymerase chain reaction confirmed that AeCLIPB9 is negatively regulated by miR-11903a.
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- Many teenagers are struggling with depression, and it keeps coming back even when they become adults, so it’s important to find ways to diagnose it better.
- The study tested 204 people, comparing healthy teens with those who just started experiencing depression, using special lab tests to find chemicals called non-esterified fatty acids (NEFA).
- The results showed that certain NEFAs were much lower in depressed teens and could help doctors spot depression earlier, but more research is needed to confirm these findings and include different groups.
Prenatal diagnosis of congenital heart disease (CHD) relies primarily on fetal echocardiography conducted at mid-gestational age-the sensitivity of which varies among centers and practitioners. An objective method for early diagnosis is needed. Here, we conducted a case-control study recruiting 103 pregnant women with healthy offspring and 104 cases with CHD offspring, including VSD (42/104), ASD (20/104), and other CHD phenotypes.
View Article and Find Full Text PDFOvarian, cervical, and endometrial cancers are the three most common gynecological cancer types (GCs). They hold a significant position as the leading causes of mortality among women with cancer-related death. However, GCs are often diagnosed late, severely limiting the efficacy of current treatment options.
View Article and Find Full Text PDFBackground: Vaccination uptake rates for adolescents are still low in China despite safe and effective human papillomavirus vaccines being available. The awareness and attitudes of parents to HPV vaccines play a decisive role in adolescents' HPV vaccination uptake.
Methods: A cross-sectional study was conducted from March, 2022 to May, 2022 using an anonymous questionnaire among parents of 9 to 18 years of age from 73 cities in 23 provinces in mainland China.
Objective: To assess the effect and safety of gum-chewing on the prevention of postoperative ileus after gynecological cancer surgery.
Methods: We conducted a systematic review of randomized controlled trials (RCTs) published between 2000 and 2022 in English and Chinese, using the EBSCO, Web of Science, Scopus, Cochrane Central Register of Controlled Trials (Cochrane database), PubMed, Medline (via Ovid), Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, and Wan Fang databases. A total of 837 studies were screened using Endnote software, and those that met the inclusion criteria were selected for analysis.
Wheat powdery mildew caused by f. sp. () is one of the most serious wheat diseases in the world.
View Article and Find Full Text PDFCan case management improve cancer patients quality of life?: A systematic review following PRISMA.
Medicine (Baltimore)
October 2020
Background: Cancer patients are associated with a series of long lasting and stressful treatments and experiencing, and case management (CM) has been widely used and developed with the aim to increase the quality of treatments and improve the patient care services. The purpose of this review is to identify and synthesize the evidence of randomized controlled trial studies to prove that case management could be one way to address the quality of life of cancer patients.
Methods: We performed a literature search in 4 electronic bibliographic databases and snowball searches were performed to ensure a complete collection.
Every organism inevitably experiences stress. In the face of acute, intense stress, for example, periods of passivity occur when an organism's actions fail to overcome the challenge. The occurrence of inactive behavior may indicate that struggling would most likely be fruitless.
View Article and Find Full Text PDFBackground: Anxiety disorders are the most common psychiatric diseases, affecting 28% of people worldwide within their lifetime. The excitation-inhibition imbalance in the amygdala is thought to be an underlying pathological mechanism; however, the cellular and molecular control of amygdala excitation-inhibition balance is largely unknown.
Methods: By using mice expressing chemogenetic activator or inhibitor channel in amygdala parvalbumin (PV) neurons, Erbin mutant mice, and mice with Erbin specifically knocked down in amygdala PV neurons, we systematically investigated the role of amygdala PV neurons and Erbin expressed therein in the pathogenesis of anxiety disorders using the combined approaches of immunohistochemistry, electrophysiology, and behavior.
Article Synopsis
- * A study found that adolescent mice developed anxiety symptoms after 2 weeks of social isolation, which was linked to increased levels of mGluR5 protein in the brain.
- * Treatments that block mGluR5, like MPEP, helped reduce anxiety behaviors and normalize neuronal activity in the amygdala, highlighting a crucial period where social isolation affects mental health.
Livestock manure is often subjected to aerobic composting but little is known about the variation in antibiotic resistance genes (ARGs) during the composting process under different concentrations of antibiotics. This study compared the effects of three concentrations of oxytetracycline (OTC; 10, 60, and 200mg/kg) on ARGs and the succession of the bacterial community during composting. Very similar trends were observed in the relative abundances (RAs) of each ARG among the OTC treatments and the control during composting.
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- Macrolides, known for their antibacterial and anti-inflammatory properties, are used in treating adults with non-cystic fibrosis bronchiectasis (NCFB), but their long-term effectiveness and safety have been debated.
- A meta-analysis of four randomized controlled trials found that macrolide treatment led to fewer pulmonary exacerbations and improved lung function, but did not enhance patients' quality of life.
- While macrolides appeared safe, there was a potential risk of increased macrolide resistance among adults with NCFB.
Objectives: We performed a systematic review and meta-analysis to assess the effects of physical activity in preventing gestational diabetes mellitus (GDM).
Search Strategy: We searched the literature in six electronic databases and bibliographies of relevant articles.
Selection Criteria: We included randomised controlled trials on pregnant women who did not have GDM and other complications previously and had increased physical activity as the only intervention.