Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity.

The functions of natural killer (NK) and T cells in innate and adaptive immunity, as well as their functions in tumor eradication, are complementary and intertwined. Here we show that utilization of multi-specific antibodies or nano-antibodies capable of simultaneously targeting both NK and T cells could be a valuable approach in cancer immunotherapy. Here, we introduce a tri-specific Nano-Antibody (Tri-NAb), generated by immobilizing three types of monoclonal antibodies (mAbs), using an optimized albumin/polyester composite nanoparticle conjugated with anti-Fc antibody.

Feasibility of using Vis-NIR spectroscopy and PXRF spectrometry to estimate regional soil cadmium concentration.

Conventionally, soil cadmium (Cd) measurements in the laboratory are expensive and time-consuming, involving complex processes of sample preparation and chemical analysis. This study aimed to identify the feasibility of using sensor data of visible near-infrared reflectance (Vis-NIR) spectroscopy and portable X-ray fluorescence spectrometry (PXRF) to estimate regional soil Cd concentration in a time- and cost-saving manner. The sensor data of Vis-NIR and PXRF, and Cd concentrations of 128 surface soils from Yunnan Province, China, were measured.

Progress in nanoparticle-based regulation of immune cells.

Immune cells are indispensable defenders of the human body, clearing exogenous pathogens and toxicities or endogenous malignant and aging cells. Immune cell dysfunction can cause an inability to recognize, react, and remove these hazards, resulting in cancers, inflammatory diseases, autoimmune diseases, and infections. Immune cells regulation has shown great promise in treating disease, and immune agonists are usually used to treat cancers and infections caused by immune suppression.

[Characteristics of Heavy Metal Pollution in Farmland Soil of the Yangtze River Economic Belt Based on Bibliometric Analysis].

The Yangtze River Economic Belt is one of the major strategic development regions in China. It is of great significance to clarify the characteristics and sources of heavy metal pollution in farmland soil of the Yangtze River Economic Belt for the prevention and control of heavy metal pollution and to ensure safe agricultural production. After collecting extensive literature data, we analyzed the pollution characteristics, environmental risk, and potential sources of heavy metals (Cd, Cr, Hg, As, Pb, Cu, Zn, and Ni) in farmland soil of the Yangtze River Economic Belt through the integrated use of spatial and geo-accumulation index analyses.

MIL-101-Cr/Fe/Fe-NH for Efficient Separation of CH and CH from Simulated Natural Gas.

Adsorptive separation based on porous solid adsorbents has emerged as an excellent effective alternative to energy-intensive conventional separation methods in a low energy cost and high working capacity manner. However, there are few stable mesoporous metal-organic frameworks (MOFs) for efficient purification of methane from other light hydrocarbons in natural gas. Herein, we report a series of stable mesoporous MOFs, MIL-101-Cr/Fe/Fe-NH, for efficient separation of CH and CH from a ternary mixture CH/CH/CH.

One and Two-Photon Excited Fluorescence Optimization of Metal-Organic Frameworks with Symmetry-Reduced AIEgen-Ligand.

By designing a tetraphenylethylene (TPE)-based AIEgen-ligand with reduced symmetry, we obtained two alkaline-earth metal-based MOFs (LIFM-102 and LIFM-103) with dense packing structures and low porosity as proved by single-crystal X-ray diffraction and CO sorption data. Excitingly, the desolvated MOFs with rigid environment and reduced lattice free solvent exhibit high quantum yields (QY, 64.9 % and 79.

240-week entecavir maleate treatment in Chinese chronic hepatitis B predominantly genotype B or C.

This study aimed to evaluate the efficacy and safety of entecavir(ETV) versus ETV maleate in Chinese patients with chronic hepatitis B(CHB). This was a randomized, double-blind, double-dummy, controlled, multicentre study. Patients were randomly assigned to receive 48 weeks of treatment with 0.

Environmental capacity of heavy metals in intensive agricultural soils: Insights from geochemical baselines and source apportionment.

Soil environmental capacity (EC) of heavy metals (HMs) can be used as an index to evaluate the pollution status of HMs and to provide basic data for HM remediation. However, the commonly used soil EC for HMs usually are prone to bias due to the lack of local background values (BVs) and the consideration of the contribution from various HM sources. Here, a modified method was proposed to estimate the soil EC by integrating the establishment of local BVs and the quantitative evaluation of contributions from HM sources in an intensive agricultural area of Shouguang city, China.

High Water Adsorption MOFs with Optimized Pore-Nanospaces for Autonomous Indoor Humidity Control and Pollutants Removal.

The indoor air quality is of prime importance for human daily life and health, for which the adsorbents like zeolites and silica-gels are widely used for air dehumidification and harmful gases capture. Herein, we develop a pore-nanospace post-engineering strategy to optimize the hydrophilicity, water-uptake capacity and air-purifying ability of metal-organic frameworks (MOFs) with long-term stability, offering an ideal candidate with autonomous multi-functionality of moisture control and pollutants sequestration. Through variant tuning of organic-linkers carrying hydrophobic and hydrophilic groups in the pore-nanospaces of prototypical UiO-67, a moderately hydrophilic MOF (UiO-67-4Me-NH -38 %) with high thermal, hydrolytic and acid-base stability is screened out, featuring S-shaped water sorption isotherms exactly located in the recommended comfortable and healthy ranges of relative humidity for indoor ventilation (45 %-65 % RH) and adverse health effects minimization (40-60 % RH).

Spatiotemporal variation and sources of soil heavy metals along the lower reaches of Yangtze River, China.

Excessive accumulation of soil heavy metals (HMs) result in the deterioration of soil quality and reduction of agricultural productivity and safety. The accumulation status, temporal change, and sources of soil HMs were determined by large-scale field surveys in 2014 and 2019 in rapid urbanization and industrialization area along the lower reaches of the Yangtze River, China. Eighty-two surface soil samples were collected in 2014 and ninety-five surface soil samples and seven soil profiles (0-100 cm) were collected in 2019.

Phthalate pollution and migration in soil-air-vegetable systems in typical plastic agricultural greenhouses in northwestern China.

Phthalate pollution in plastic greenhouses (PGs) has aroused concerns. However, mechanisms and factors of vegetables planted in PGs (VPGs) accumulating phthalates from soil and air are unclear. To fill the gap, 19 PGs in Shaanxi, the largest vegetable production province in northwestern China, were selected to probe this issue.

Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients: Results of a multicenter, double-blind, double-dummy, clinical trial at 96 weeks.

Background: Tenofovir disoproxil fumarate (TDF) is a prodrug of a nucleotide analogue. As an antiviral drug, TDF has been proposed in the first-line treatment of chronic hepatitis B (CHB). Qingzhong, a brand name of TDF, commercialized by Jiangsu Chia-tai Tianqing Pharmaceutical Co Ltd.

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy.

Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) could potentially associate with both cells and bridge them together like an 'adaptor' while maintaining the immunomodulatory properties of the parental mAbs. However, existing mAbs-immobilization strategies mainly rely on a chemical reaction, a process that is rough and difficult to control.

Atmospheric phthalate pollution in plastic agricultural greenhouses in Shaanxi Province, China.

Phthalate pollution in soil and vegetables in plastic agricultural greenhouses has attracted wide concern. Investigating airborne phthalates in this environment can improve understanding of air-soil or air-vegetable phthalate migration. However, studies of phthalates in plastic agricultural greenhouse air are rare.

An All-in-One Nanomedicine Consisting of CRISPR-Cas9 and an Autoantigen Peptide for Restoring Specific Immune Tolerance.

Nanotechnology has shown great promise in treating diverse diseases. However, developing nanomedicines that can cure autoimmune diseases without causing systemic immunosuppression is still quite challenging. Herein, we propose an all-in-one nanomedicine comprising an autoantigen peptide and CRISPR-Cas9 to restore specific immune tolerance by engineering dendritic cells (DCs) into a tolerogenic phenotype, which can expand autoantigen-specific regulatory T (Treg) cells.

Programmable Delivery of Immune Adjuvant to Tumor-Infiltrating Dendritic Cells for Cancer Immunotherapy.

Tumor-infiltrating dendritic cells (TIDCs) are mostly immature and immunosuppressive, usually mediating immune inhibition. The utilization of cytosine-guanine oligodeoxynucleotides (CpG ODNs) to stimulate the activation of TIDCs has been demonstrated to be effective for improving antitumor immunity. However, a series of biological barriers has limited the efficacy of previous nanocarriers for delivering CpG to TIDCs.

Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal Glands.

Glutamate and its receptors have been demonstrated to promote both basal and nicotine-evoked catecholamine release in bovine chromaffin cells. Multiple glutamate receptors, including metabotropic glutamate receptors (mGluRs), are found in the adrenal glands of several species, as well as in chromaffin cells. However, there is limited information available regarding the expression of glutamate metabotropic receptor mRNAs and the detailed localization of group I mGluRs (mGluR1 and mGluR5) in the rat and human adrenal cortex and medulla.

Expression of BACE1 in the Rat Carotid Body.

This study explored the expression of BACE1 (β-amyloid precursor protein cleaving enzyme 1) in the rat carotid body and the effect of CIH (cyclic intermittent hypoxia) on the expression of BACE1. We found that BACE1 was expressed in the rat carotid body and located in the nerve endings and type II cells but not in type I cells. CIH reduced BACE1 level in the carotid body, and reoxygenation or ROS scavenger alleviated this reduction.

Dynamic Coordination Chemistry of Fluorinated Zr-MOFs: Synthetic Control and Reassembly/Disassembly Beyond de Novo Synthesis to Tune the Structure and Property.

Known for excellent stability, porosity and functionality, the high-valent Zr metal-organic frameworks (Zr-MOFs) still meets synthetic challenge in modulating the strength of Zr-O linkage. Herein we explore the unusual coordination dynamics of fluorinated Zr-MOFs by designing two trifluoromethyl modified ligands with distinct geometry preference to form a family of thermodynamic and kinetic products. The low-connecting kinetic Zr-MOFs possess substitutable coordination sites to endow Zr -cluster with extra dynamic behaviors, thus opening a post-synthetic pathway to sequential reassembly/disassembly processes.

Pressure-Induced Multiphoton Excited Fluorochromic Metal-Organic Frameworks for Improving MPEF Properties.

In multiphoton excited fluorescence (MPEF), high-energy upconversion emission is obtained from low-energy excitation by absorbance of two or more photons simultaneously. In a pressure-induced fluorochromic process, the emission energy is switched by outer pressure stimuli. Now, five metal-organic frameworks containing the same ligand with simultaneous multiphoton absorption and pressure-induced fluorochromic attributes were studied.