Publications by authors named "Ya-nan Cui"
Disulfide bond (Dsb) proteins, especially DsbA, represent a promising but as-yet-unrealized target in combating multidrug-resistant (MDR) bacteria because their precise subcellular targeting through multibarrier remains a significant challenge. Here, a novel heterogenization-phase-separated nano-antibiotics (NCefoTs) is proposed, through the co-assembly of enzyme-inhibiting lipopeptides (ELp component), membrane-recognizing and disrupting lipopeptides (MLp component), and cefoperazone. The self-sorting components of MLp "concentrated island-liked clusters" on the surface of NCefoTs promote the efficient penetration of NCefoTs through the outer membrane.
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- The study investigated the effects of high-dose vitamin C (VC) on survival rates and cardiac function in rats with sepsis-induced myocardial injury (SIMI) over a period of 7 days.
- Rats were split into three groups: a sham group, a group with SIMI, and a high-dose VC group, with treatment durations of 1, 3, or 5 days.
- The findings suggested that high-dose VC improved survival and cardiac function in SIMI rats by reducing apoptosis and inflammation, while enhancing autophagy through specific signaling pathways.
[Effects of revegetation on soil nitrogen-fixation and carbon-fixation microbial communities in the Horqin Sandy Land, China].
Ying Yong Sheng Tai Xue Bao
January 2024
Article Synopsis
- * Results show that vegetation type significantly influences soil properties, microbiological activities, and the diversity of these microbial communities, with certain plantations exhibiting higher diversity in both nitrogen and carbon-fixers.
- * Soil characteristics like organic matter and nutrients were found to play key roles in shaping these microbial communities, providing valuable insights for evaluating the ecological benefits of re-vegetation practices in sandy areas.
Clinical Efficacy of Auricular Acupressure plus Eye Exercises in the Treatment of Adolescent Pseudomyopia.
Evid Based Complement Alternat Med
June 2022
Objective: To assess the clinical efficacy of auricular acupressure plus eye exercises in the treatment of adolescent pseudomyopia, to discover an easier and safer way to treat pseudomyopia.
Methods: Forty adolescent patients with pseudomyopia were randomly recruited and assigned (1 : 1) to receive either eye exercises (single group, including 11 males and 9 females) or auricular acupressure plus eye exercises (combined group, including 12 males and 8 females). The clinical endpoint was the clinical efficacy after 28 days of treatment.
Article Synopsis
- - Recent years have seen a surge in research on hydrogel-based materials in biomedical engineering, with cellulose-based hydrogels becoming especially popular due to their notable properties like flexibility, biocompatibility, and environmental safety.
- - This review outlines the various sources and types of cellulose, how hydrogel formation occurs, and the latest advancements in cellulose-based hydrogels, including their uses in ionic conduction, thermal insulation, and drug delivery.
- - The authors highlight emerging trends and future opportunities for cellulose-based hydrogels, suggesting significant potential for development in functional material applications.
Sex-specific differences in the gut microbiota and fecal metabolites in an adolescent valproic acid-induced rat autism model.
Front Biosci (Landmark Ed)
December 2021
Background: Alterations in the microbiota-gut-brain axis are associated with the onset of autism spectrum disorder (ASD). Numerous studies have reported that the gut microbiota (GM) is significantly altered in individuals with ASD and animal models of ASD. However, few studies have focused on sex-specific differences in the GM and fecal metabolites of ASD.
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- The buildup of bacteria at the edges of dental resin composites leads to secondary cavities, necessitating antibacterial activity to prevent prosthodontic failures.
- Regular-shaped SiO2-ZnO complex clusters created through spray-drying can improve antibacterial properties without compromising the mechanical and aesthetic qualities of the composites.
- Composites with 70 wt% Si66Zn4 (made up of 66% SiO2 and 4% ZnO) demonstrated over 99.9% antibacterial efficacy and maintained acceptable levels of depth of cure, conversion, and biocompatibility.
[Gastric carcinoid tumor with micro-mucinous adenocarcinoma: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2010
[Effects of minimal persistent inflammation on nasal mucosa of experimental allergic rhinitis in guinea pigs].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2008
Objective: To establish an animal model of minimal persistent inflammation (MPI) of allergic rhinitis in guinea pigs and to investigate the changes of nasal mucosa. The expression of transforming growth factor-beta1 (TGF-beta1) and matrix metalloproteinases-9 (MMP-9) were discussed.
Methods: Thirty male Hartley guinea pigs were randomly divided into two groups: MPI model group and control group randomly, with fifteen animals in each group.
[Establishment and significance of the experimental minimal persistent inflammation models in allergic rhinitis guinea pigs].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
June 2008
Article Synopsis
- The study aimed to create an animal model of minimal persistent inflammation (MPI) in guinea pigs to understand its role in allergic rhinitis.
- Sixty male Hartley guinea pigs were divided into four groups, receiving various treatments with ovalbumin (OVA) to observe symptoms and immune responses after nasal challenges.
- Findings showed that MPI models can be effectively established in guinea pigs, highlighting increased eosinophil infiltration and mild expression of ICAM-1, providing a foundation for future research on allergic rhinitis mechanisms and treatments.
[Expression of proto-oncogenes c-fos and c-jun in osteoblasts activated by excessive fluoride].
Zhonghua Yu Fang Yi Xue Za Zhi
July 2003
Article Synopsis
- The study aimed to investigate how excessive fluoride affects the expression of proto-oncogenes c-fos and c-jun in osteoblasts, both in living rats and in cultured cells.
- Rats were given sodium fluoride in their drinking water, and osteoblast-like cells were exposed to fluoride in a lab setting; researchers measured mRNA and protein levels of c-fos and c-jun using specific laboratory techniques.
- Results showed that fluoride exposure enhanced the proliferation of osteoblasts and significantly increased the expression of c-fos and c-jun in both rats and cultured cells, suggesting a potential link between fluoride and altered bone cell activity.